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Menzorov M.V.

Kafedra terapii i professional'nykh bolezneĭ meditsinskogo fakul'teta Ul'ianovskogo gosudarstvennogo universiteta

Shutov A.M.

FGBOU VPO "Ul'ianovskiĭ gosudarstvennyĭ universitet"

Midlenko V.I.

Ulyanovsk State University, Ulyanovsk, Russia

Larionova N.V.

Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia

Morozova I.V.

Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia

Akulova O.V.

Ulyanovsk State University, Ulyanovsk, Russia

Value of N-terminal pro brain natriuretic peptide in predicting acute kidney injury in patients with acute decompensated chronic heart failure

Authors:

Menzorov M.V., Shutov A.M., Midlenko V.I., Larionova N.V., Morozova I.V., Akulova O.V.

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Journal: Therapeutic Archive. 2017;89(3): 78‑84

DOI: 10.17116/terarkh201789378-84

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Table of contents

VALUE OF N-TERMINAL PRO BRAIN NATRIURETIC PEPTIDE IN PREDICTING ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE DECOMPENSATED CHRONIC HEART FAILURE
VALUE OF N-TERMINAL PRO BRAIN NATRIURETIC PEPTIDE IN PREDICTING ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE DECOMPENSATED CHRONIC HEART FAILURE

To cite this article:

Menzorov MV, Shutov AM, Midlenko VI, Larionova NV, Morozova IV, Akulova OV. Value of N-terminal pro brain natriuretic peptide in predicting acute kidney injury in patients with acute decompensated chronic heart failure. Therapeutic Archive. 2017;89(3):78‑84. (In Russ.)
https://doi.org/10.17116/terarkh201789378-84

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Abstract:

Aim. To investigate the prognostic value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) in the development of acute kidney injury (AKI) in patients with acute decompensated chronic heart failure (ADCHF). Subjects and methods. Eighty-three patients (55 (66%) men and 28 (34%) women; mean age, 65±11 years) with ADCHF were examined. AKI was diagnosed and classified according to the 2012 Kidney Disease Improving Global Outcomes Clinical Practice guidelines. To rule out contrast-induced AKI, the investigation enrolled only patients in whom radiopague agents had not been injected 7 days before and during hospitalization. Enzyme immunoassay was used to determine serum NT-proBNP concentrations in all the patients upon hospital admission. Results. AKI was diagnosed in 18 (22%) patients, 13 (16%) had Stage I, 4 (5%) had Stage II, and 1 (1%) had Stage III. The serum concentration of NT-proBNP was significantly higher in patients with AKI than that in the other patients [1512.1 (981.0; 2246.2) and 861.8 (499.0; 1383.6) pg/ml (p=0.008). The rise in NT-proBNP concentrations of more than 942 pg/ml was established to be associated with a considerable increase in the risk of AKI (relative risk (RR) was 4.3; 95% confidence interval (CI), 1.27—14.90; p=0.02). RОС analysis indicated that a NT-proBNP level of >942 pg/ml allows prediction of AKI with a sensitivity of 78% (52; 94) and a specificity of 55% (44; 69) (AUC=0.70; p=0.006). Four (5%) patients died in hospital. NT-proBNP levels in all the dead were greater than 942 pg/ml. Two of the 4 deceased patients had AKI. Conclusion. A high level of NT-proBNP in a patient with ADCHF during hospitalization can serve as a biomarker for high risk of AKI and for high mortality rates.

Keywords:

N-terminal pro-brain natriuretic peptide
acute kidney injury
acute decompensated chronic heart failure

Authors:

Menzorov M.V.

Kafedra terapii i professional'nykh bolezneĭ meditsinskogo fakul'teta Ul'ianovskogo gosudarstvennogo universiteta

Shutov A.M.

FGBOU VPO "Ul'ianovskiĭ gosudarstvennyĭ universitet"

Midlenko V.I.

Ulyanovsk State University, Ulyanovsk, Russia

Larionova N.V.

Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia

Morozova I.V.

Department of Therapy and Occupational Diseases, Medical Faculty, Ulyanovsk State University, Ulyanovsk, Russia

Akulova O.V.

Ulyanovsk State University, Ulyanovsk, Russia

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