Aim. To analyze the association of the promoter polymorphism of the genes of the matrix metalloproteinases (MMP) MMP2 (–1306), MMP3 (–1171), and MMP9 (–1562) and two vascular endothelial growth factor (VEGF) gene regulatory regions (–2578, +936) with the development of myocardial infarction (MI). Materials and methods. DNA was analyzed in 251 patients with a history of MI. Five polymorphic positions were genotyped by restrictase analysis of amplification products, by using specific primers. Results. In addition to the MMP3 5A5A monogenotype, there were 4 complex genotypes that were significantly different between two analyzed groups and positively associated with acute coronary syndrome. Among them, each of two genotypes included 2 polymorphic positions; two genotypes did 3 analyzed polymorphic positions. Four complex (two-locus (n=1), three-locus (n=2), four-locus (n=1) genotypes that were negatively associated with MI were also identified. Conclusion. These findings are evidence in favor of our assumption that the increasing number of genotypes as part of the analyzed combined genetic complexes detectable in one patient considerably enhances the clinical significance of the results of immunogenetic analysis.