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Slesarchuk O.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Babenko E.V.

Institut detskoĭ onkologii, gematologii i transplantologii im. R.M. Gorbachevoĭ, SPbGMU im. akad. I.P. Pavlova

Semenova E.V.

B.V. Petrovsky Russian Research Center of Surgery ,Department of Acquired Heart Valvular Diseases, Moscow, Russia

Bondarenko S.N.

Institut detskoĭ onkologii, gematologii i transplantologii im. R.M. Gorbachevoĭ, SPbGMU im. akad. I.P. Pavlova

Éstrina M.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Morozova E.V.

Otdelenie rentgenokhirurgicheskikh metodov diagnostiki i lecheniia FGBU "FTs SSKh" Minzdravsotsrazvitiia Rossii, Penza

Paina O.V.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Vavilov V.N.

Institut detskoĭ onkologii, gematologii i transplantologii im. R.M. Gorbachevoĭ, SPbGMU im. akad. I.P. Pavlova

Smirnov B.I.

Sankt-Peterburgskiĭ gosudarstvennyĭ élektrotekhnicheskiĭ universitet im. V.I. Ul'ianova

Zubarovskaia L.S.

Klinika "Institut detskoĭ gematologii i transplantologii im. R.M. Gorbachevoĭ" Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

Afanas'ev B.V.

Klinika "Institut detskoĭ gematologii i transplantologii im. R.M. Gorbachevoĭ" Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

Efficacy of donor lymphocyte infusion in patients after different types of allogeneic hematopoietic stem cell transplantation

Authors:

Slesarchuk O.A., Babenko E.V., Semenova E.V., Bondarenko S.N., Éstrina M.A., Morozova E.V., Paina O.V., Vavilov V.N., Smirnov B.I., Zubarovskaia L.S., Afanas'ev B.V.

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Journal: Therapeutic Archive. 2013;85(7): 26‑33

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EFFICACY OF DONOR LYMPHOCYTE INFUSION IN PATIENTS AFTER DIFFERENT TYPES OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
EFFICACY OF DONOR LYMPHOCYTE INFUSION IN PATIENTS AFTER DIFFERENT TYPES OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

To cite this article:

Slesarchuk OA, Babenko EV, Semenova EV, et al. . Efficacy of donor lymphocyte infusion in patients after different types of allogeneic hematopoietic stem cell transplantation. Therapeutic Archive. 2013;85(7):26‑33. (In Russ.)

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Abstract:

Aim. To evaluate the efficacy of donor lymphocyte infusion (DLI) to prevent and treat recurrences in patients after different types of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Subjects and methods. Data from 118 patients with malignant blood diseases were analyzed. Allo-HSCTs from HLA-matched related donors (n=49), HLA-matched unrelated donors (n=50), partially HLA-matched unrelated donors (n=2), and haploidentical donors (n=24) were performed. The indications for DLI were underlying disease relapse (59 DLIs), resistant disease course (n=40), minimal residual disease (n=16), falling donor chimerism (n=15), and recurrence prevention (n=13). Results. Therapy response was obtained after 57 (44%) DLIs. There were 36 (25%) and 30 (21%) cases of acute and chronic graft-versus-host reactions (GVHR), respectively. The use of DLI from HLA-matched donors, its performance in the periods of D+100 to one year after allo-HSCT, a donor chimerism level of over 90% at the moment of DLI, the administration of the initial DLI dose of below 1·106 CD3+/kg, and the development of chronic GVHR after DLI were associated with the highest rate of therapy responses. The overall survival rates of patients with DLI were significantly influenced by factors, such as DLI periods, donor chimerism levels at DLI, and the development of chronic GVHR after DLI. Conclusion. The choice of the optimal dose of cells, the periods of DLI and its preventive administration improve prognosis in patients after allo-HSCT. The occurrence of acute GVHR is affected by the degree of HLA matching and the type of a donor. The development of chronic GVHR after DLI is associated with the highest rate of responses to DLI and higher survival rates.

Keywords:

allogeneic hematopoietic stem cell transplantation
underlying disease relapse
donor lymphocyte infusion

Authors:

Slesarchuk O.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Babenko E.V.

Institut detskoĭ onkologii, gematologii i transplantologii im. R.M. Gorbachevoĭ, SPbGMU im. akad. I.P. Pavlova

Semenova E.V.

B.V. Petrovsky Russian Research Center of Surgery ,Department of Acquired Heart Valvular Diseases, Moscow, Russia

Bondarenko S.N.

Institut detskoĭ onkologii, gematologii i transplantologii im. R.M. Gorbachevoĭ, SPbGMU im. akad. I.P. Pavlova

Éstrina M.A.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Morozova E.V.

Otdelenie rentgenokhirurgicheskikh metodov diagnostiki i lecheniia FGBU "FTs SSKh" Minzdravsotsrazvitiia Rossii, Penza

Paina O.V.

Sankt-Peterburgskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. akad. I.P. Pavlova

Vavilov V.N.

Institut detskoĭ onkologii, gematologii i transplantologii im. R.M. Gorbachevoĭ, SPbGMU im. akad. I.P. Pavlova

Smirnov B.I.

Sankt-Peterburgskiĭ gosudarstvennyĭ élektrotekhnicheskiĭ universitet im. V.I. Ul'ianova

Zubarovskaia L.S.

Klinika "Institut detskoĭ gematologii i transplantologii im. R.M. Gorbachevoĭ" Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

Afanas'ev B.V.

Klinika "Institut detskoĭ gematologii i transplantologii im. R.M. Gorbachevoĭ" Sankt-Peterburgskogo gosudarstvennogo meditsinskogo universiteta im. I.P. Pavlova

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