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Sukhanov D.S.

Sankt-Peterburgskaia gosudarstvennaia meditsinskaia akademiia im. I.I. Mechnikova

Immunotropic therapy for tuberculosis infection

Authors:

Sukhanov D.S.

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Journal: Therapeutic Archive. 2013;85(3): 110‑117

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IMMUNOTROPIC THERAPY FOR TUBERCULOSIS INFECTION
IMMUNOTROPIC THERAPY FOR TUBERCULOSIS INFECTION

To cite this article:

Sukhanov DS. Immunotropic therapy for tuberculosis infection. Therapeutic Archive. 2013;85(3):110‑117. (In Russ.)

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Abstract:

The review summarizes current views on the immunopathogenesis of tuberculosis infection. It shows the leading role of a Th1 cytokine response in the formation of antituberculosis protective immunity and the impact of cytokine balance on disease outcomes. Data on the efficacy of current groups of immunomodulators used in the therapy of tuberculosis (immunomodulators, peptides, cytokine preparations, and synthetic immunomodulators of different chemical structures) are considered. Particular emphasis is placed on a group of interferon inducers as drugs for pathogenetic therapy, of which cycloferon is most important. The data of studies of the effect of cycloferon on the elaboration of interferon-γ that is able to activate a Th1 immune response, which promotes the shorter time of abacillation and decay cavity closure and positive X-ray changes, are given.

Keywords:

tuberculosis
immunomodulators
cycloferon
interferon-gamma
X-ray changes
abacillation

Authors:

Sukhanov D.S.

Sankt-Peterburgskaia gosudarstvennaia meditsinskaia akademiia im. I.I. Mechnikova

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