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Berezovskiĭ D.P.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Varavva T.A.

NII biologii Iuzhnogo federal'nogo universiteta, Rostov-na-Donu;
kspertno-kriminalisti­cheskiĭ tsentr Glavnogo upravleniia MVD Rossii po Rostovskoĭ oblasti

Faleeva T.G.

Kafedra sudebnoĭ meditsiny s kursom pravovedeniia Rostovskogo gosudarstvennogo meditsinskogo universiteta;
Filial #2 111-go FGKU "Gosudarstvennyĭ tsentr sudebno-meditsinskikh i kriminalisticheskikh kspertiz" Minoborony Rossii, Rostov-na-Donu

Pigolkin Yu.I.

Sechenov’s First Moscow State Medical University, Moscow, Russia

Kornienko I.V.

FGAOU "Iuzhnyĭ federal'nyĭ universitet", Rostov-na-Donu

Forensic medical evaluation of hereditary predisposition to thrombophilia in the case of thrombotic complications of a mechanical injury

Authors:

Berezovskiĭ D.P., Varavva T.A., Faleeva T.G., Pigolkin Yu.I., Kornienko I.V.

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Journal: Forensic Medical Expertise. 2014;57(1): 22‑25

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Table of contents

FORENSIC MEDICAL EVALUATION OF HEREDITARY PREDISPOSITION TO THROMBOPHILIA IN THE CASE OF THROMBOTIC COMPLICATIONS OF A MECHANICAL INJURY
FORENSIC MEDICAL EVALUATION OF HEREDITARY PREDISPOSITION TO THROMBOPHILIA IN THE CASE OF THROMBOTIC COMPLICATIONS OF A MECHANICAL INJURY

To cite this article:

Berezovskiĭ DP, Varavva TA, Faleeva TG, Pigolkin YuI, Kornienko IV. Forensic medical evaluation of hereditary predisposition to thrombophilia in the case of thrombotic complications of a mechanical injury. Forensic Medical Expertise. 2014;57(1):22‑25. (In Russ.)

Подписка 2026 Судебно-медицинская экспертиза (Forensic Medical Expertise)
МСФ на ЯМ
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Abstract:

The objective of the present work was to develop the forensic medical criteria for the assessment of the significance of hereditary predisposition to thrombophilia in the case of thrombotic complications of a mechanical injury. The results of analysis of the frequency of genes responsible for hereditary predisposition to thrombogenesis (FII, FV, MTHFR, FGB, PAI-1) among the victims of mechanical injuries are presented. A total of 251 subjects were available for the examination. They were divided into 4 groups as follows: the subjects presenting with deep venous thrombosis in the lower extremities (DVTLE) after the injury (group 1), subjects with DVTLE without the preceding trauma (group 2), those with an injury to the locomotor apparatus without a subsequent thrombotic complication (group 3), and practically healthy persons (group 4). It was shown that the subjects of group I had the highest frequency of mutations and polymorphisms of MTHFR and PAI-1 genes. It is concluded that genetic typing for the detection of mutations in these two genes is indispensable for the subjects presenting with thrombotic complications after mechanical injuries to the locomotor organs.

Keywords:

thrombophilia
thrombosis
injury

Authors:

Berezovskiĭ D.P.

GBOU VPO "Rostovskiĭ gosudarstvennyĭ meditsinskiĭ universitet"

Varavva T.A.

NII biologii Iuzhnogo federal'nogo universiteta, Rostov-na-Donu;
kspertno-kriminalisti­cheskiĭ tsentr Glavnogo upravleniia MVD Rossii po Rostovskoĭ oblasti

Faleeva T.G.

Kafedra sudebnoĭ meditsiny s kursom pravovedeniia Rostovskogo gosudarstvennogo meditsinskogo universiteta;
Filial #2 111-go FGKU "Gosudarstvennyĭ tsentr sudebno-meditsinskikh i kriminalisticheskikh kspertiz" Minoborony Rossii, Rostov-na-Donu

Pigolkin Yu.I.

Sechenov’s First Moscow State Medical University, Moscow, Russia

Kornienko I.V.

FGAOU "Iuzhnyĭ federal'nyĭ universitet", Rostov-na-Donu

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References:

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