Optimization of the diagnosis of precancerous diseases of the oral mucosa and lips (Manganotti’s abrasive precancerous cheilitis and erythroplakia)

Rabinovich O.F.

Peoples’ Friendship University of Russia

ORCID: 0000-0002-1018-9017

Rabinovich I.M.

Peoples’ Friendship University of Russia

ORCID: 0000-0001-8539-814X

Babichenko I.I.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0001-5512-6813

Syomkin V.A.

Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation

Umarova K.V.

Central Research Institute of Dentistry and Maxillofacial Surgery

Shindich O.I.

Central Research Institute of Dentistry and Maxillofacial Surgery

Optimization of the diagnosis of precancerous diseases of the oral mucosa and lips (Manganotti’s abrasive precancerous cheilitis and erythroplakia)

Authors:

Rabinovich O.F., Rabinovich I.M., Babichenko I.I., Syomkin V.A., Umarova K.V., Shindich O.I.

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Journal: Stomatology. 2021;100(6‑2): 16‑21

DOI: 10.17116/stomat202110006216

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To cite this article:

Rabinovich OF, Rabinovich IM, Babichenko II, Syomkin VA, Umarova KV, Shindich OI. Optimization of the diagnosis of precancerous diseases of the oral mucosa and lips (Manganotti’s abrasive precancerous cheilitis and erythroplakia). Stomatology. 2021;100(6‑2):16‑21. (In Russ.)
https://doi.org/10.17116/stomat202110006216

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OBJECTIVE

To optimize the identification of precancerous diseases of the oral mucosa, such as Manganotti’s abrasive precancerous cheilitis and erythroplakia of the oral mucosa using markers Ki-67 and keratin 15.

MATERIAL AND METHODS

The study group included 17 patients with Manganotti’s abrasive precancerous cheilitis and 8 with erythroplakia of the oral mucosa. A histological analysis was carried out to scrutinize the biopsy material of the oral mucosa of the patients. Ki-67 protein and keratin 15 were used to assess the proliferative activity of epithelial cells and the severity of neoplasia. Results. Thirteen patients with Manganotti’s cheilitis had dysplasia of varying degrees, and 4 had signs of malignancy. A high proliferative activity of the Ki-67 protein was found in the stratum basal and stratum spinosum of the epithelium. In 5 patients with erythroplakia, according to histological examination, grade 2—3 intraepithelial neoplasia was revealed and 3 patients had cancer in situ. The expression of keratin 15 in all patients with Manganotti’s abrasive precancerous cheilitis and erythroplakia in the basal layer tended to decrease with an increase in the degree of dysplasia, however, the appearance of keratin 15 in the cytoplasm of cells located above the basal layer was discovered.

CONCLUSION

The use of Ki-67 protein and keratin 15 as immunohistochemical markers in the study of diseases such as Manganotti’s abrasive precancerous cheilitis and erythroplakia of the oral mucosa makes it possible to identify the initial signs of malignancy more accurately in the epithelium.

Keywords:

keratin 15

Ki-67

oral mucosa

precancerous diseases

Authors:

Rabinovich O.F.

Peoples’ Friendship University of Russia

ORCID: 0000-0002-1018-9017

Rabinovich I.M.

Peoples’ Friendship University of Russia

ORCID: 0000-0001-8539-814X

Babichenko I.I.

Peoples’ Friendship University of Russia;
Central Research Institute of Dentistry and Maxillofacial Surgery

ORCID: 0000-0001-5512-6813

Syomkin V.A.

Federal State Institution Central Research Institute of Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation

Umarova K.V.

Central Research Institute of Dentistry and Maxillofacial Surgery

Shindich O.I.

Central Research Institute of Dentistry and Maxillofacial Surgery

Received:

07.11.2021

Accepted:

24.11.2021

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