Objective — to determine the specific features of cervical infection associated with human papillomavirus (HPV) types 52, 58, and 59. Subject and methods. Eighty-four patients aged 18—58 years with cervical infection associated with HPV types 52, 58, and 59 were examined. Comprehensive diagnosis encompassed liquid-based cytology, colposcopy, histological examination of cervical biopsy specimens and endocervical samples, expanding screening for the differential detention of HPV DNA. The data were statistically processed using a Statistica-6 package and Microsoft Excel’s capabilities. Results. There was a large proportion (79.8%) of women younger than 35 years among the female patients infected with HPV types 52, 58, and 59. The forms of cervical HPV infection showed the following prevalence rates: 14.3% for latent infection, 28.6% for subclinical one, 54.8% for cervical intraepithelial neoplasia (CIN), and 2.4% for cancer of the cervix uteri. The incidence of subclinical HPV infection was higher in patients of early reproductive age than that in 26—35-year-old patients in whom CIN occurrence was more prevalent (p < 0.05). Mixed HPV infection cases were ascertained to constitute a substantial proportion (56%). In monoinfection and mixed infection, cervical neoplasia (CIN and cancer of the cervix uteri) was seen in 20 and 28 cases, respectively (p=0.39). Analysis of the relationship between HPV infection forms and viral load established that CIN women with a load of greater than 5 lg per 105 cells were twice more (p<0.05). Monoinfection displayed a relationship between the severity of a HPV infection form and viral load of HPV types 52, 58, and 59 (2I = 16.29; p<0.05). Conclusion. The infection associated with HPV types 52, 58, and 59 was attended by CIN and cervical cancer in 57.1% of cases. In monoinfection, the high incidence (54%) of cervical neoplasia, which is comparable with that concurrent with other high-risk HPV types (59.6%; p>0.05) and the association between the severity of a cervical lesion with viral load confirm the high risk of cervical precancer and cancer in the presence of monoinfection with HPV types 52, 58, and 59. The authors declare no conflicts of interest.