Objective. To design personalized allografts for reconstruction of the structures of the facial skeleton, using a three-dimensional simulation and 3D-printing technologies. Material and methods. A total of 108 patients were operated on in the period 2009 to 2016. To design the most personalized allografts, a computed scan of each patient was converted to a virtual 3D model by a semi-automatic segmentation method, followed by the creation of a plastic replica of a patient’s skull, by using 3D-printing technologies and laser allograft modeling. Results. Among the 108 patients there were those who had been operated on for defects of the anterolateral wall of the maxillary sinus (n=43), the bottom wall of the orbit (n=15), the anterior wall of the frontal sinus (n=22, including 18 patients after removal of osteomas in the frontal sinuses, and for saddle nose deformity (n=28). According to the SNOT-22 questionnaire survey of the patients, the proposed methods were effective in surgically closing a sinonasal wall defect with a personalized allograft. Conclusion. The application of personalized allografts designed using computer 3D-modeling and 3D printing can be recommended during reconstructive plastic surgery in otorhinolaryngology.