Clinical and genetic predictors of esophageal mucosal lesions in gastroesophageal reflux disease in the Transbaikal region

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OBJECTIVE

To evaluate the prognostic role of GERD clinical course pattern and polymorphisms of IL-1β, IL-10, IL-12β and GNBβ3 genes in the development of erosive esophagitis among the residents of Transbaikal region.

MATERIAL AND METHODS

Sixty-two patients (30 males and 49 females) with GERD were included in the study, with a median and interquartile interval of age 43 [33; 47] year. Independent risk factors of esophageal mucosal changes in patients with GERD were determined using binary logistic regression analysis.

RESULTS AND CONCLUSION

The authors developed the prognostic model of erosive esophagitis according to which the presence of hiatal hernia of diaphragmatic opening (HES), DeMesster coefficient 14.72 and more, IL-1β T511c and GNB3β C825T genotypes can be considered as additional predictors of erosive reflux esophagitis in patients with GERD, residing in Transbaikal region.

Keywords:

erosive esophagitis

risk factors

gastroesophageal reflux disease

Authors:

Zhilina A.A.

Chita State Medical Academy

Lareva N.V.

Chita State Medical Academy

Zwinger S.M.

Chita State Medical Academy

Received:

15.10.2021

Accepted:

29.11.2021

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