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Gumanova N.G.

National Medical Research Center for Therapy and Preventive Medicine

Nitric oxide and its circulating NOx metabolites, their role in human body functioning and cardiovascular death risk prediction (part I)

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Gumanova N.G.

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Journal: Russian Journal of Preventive Medicine. 2021;24(9): 102‑109

DOI: 10.17116/profmed202124091102

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To cite this article:

Gumanova NG. Nitric oxide and its circulating NOx metabolites, their role in human body functioning and cardiovascular death risk prediction (part I). Russian Journal of Preventive Medicine. 2021;24(9):102‑109. (In Russ.)
https://doi.org/10.17116/profmed202124091102

 
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Nitric oxide (NO) is one of the most important regulators of key signaling pathways of many life support systems. In the human body, there is a cycle of NO, in which this molecule is oxidized to nitrite-ion (NO2–), then NO2– is oxidized to nitrate-ion (NO3–), and finally NO is reduced over from NO3– through NO2– via several enzymes. Due to important biological and physiological activities of all the components of this cycle, including being regulators of the cardiovascular system, this review addresses the role of the elements of the existing cycle in the regulation of the vital systems of the human body and predicting the risk of cardiovascular death. In the first part of the review, the properties of NO, the details of its synthesis, and the history of its discovery are discussed.

Keywords:

nitric oxide
NO
nitrate ions
NO3–
nitrite ions
NO2–
nitrosylation
cardiovascular disease
cardiovascular risk

Authors:

Gumanova N.G.

National Medical Research Center for Therapy and Preventive Medicine

Received:

29.04.2021

Accepted:

04.06.2021

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