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Guryanova E.A.

Ulyanov Chuvash State University

Sharafutdinova N.N.

Chuvash state university named after I. N. Ulyanov

Heart damage in COVID-19

Authors:

Guryanova E.A., Sharafutdinova N.N.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2021;24(11): 112‑116

DOI: 10.17116/profmed202124111112

Views: 855

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To cite this article:

Guryanova EA, Sharafutdinova NN. Heart damage in COVID-19. Russian Journal of Preventive Medicine. 2021;24(11):112‑116. (In Russ.)
https://doi.org/10.17116/profmed202124111112

 
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This article provides a review of the results of studies of COVID-19 effects. The effects of SARS-CoV-2 infection on the heart mediated by the virus specificity to ACE-2 protein and the relation of COVID-19 to cardiovascular diseases are discussed. The causes of cardiac damage in coronavirus infection related to systemic inflammation, platelet activation, endothelial dysfunction, and vasoconstriction are reviewed. Different opinions on whether myocardial damage with elevated troponin levels is a mediator or marker of adverse outcomes are presented. The analysis also discusses the consequences of SARS-CoV-2 infection, such as post-active COVID-19 syndrome for persistent symptoms after three weeks and chronic COVID-19 syndrome after 12 weeks, as well as the relationship between COVID-19 and postural tachycardia syndrome, characterized by changes in HR with changes in position, often accompanied by increased heart rate and decreased exercise tolerance.

Keywords:

COVID-19
coronavirus infection
cardiovascular disease
troponin
arterial hypertension

Authors:

Guryanova E.A.

Ulyanov Chuvash State University

Sharafutdinova N.N.

Chuvash state university named after I. N. Ulyanov

Received:

31.08.2021

Accepted:

04.10.2021

List of references:

  1. Ahmad FB, Anderson RN. The leading causes of death in the US for 2020. JAMA. 2021;325(18):1829-1830. https://doi.org/10.1001/jama.2021.5469
  2. Hendren NS, Drazner MH, Bozkurt B, Cooper LT Jr. Description and proposed management of the acute COVID-19 cardiovascular syndrome. Circulation. 2020;141(23):1903-1914. https://doi.org/10.1161/CIRCULATIONAHA.120.047349
  3. Clerkin KJ, Fried JA, Raikhelkar J, Sayer G, Griffin JM, Masoumi A, Jain SS, Burkhoff D, Kumaraiah D, Rabbani LR, Schwartz A, Uriel N. COVID-19 and cardiovascular disease. Circulation. 2020;141(20):1648-1655. https://doi.org/10.1161/CIRCULATIONAHA.120.046941
  4. Khan MS, Shahid I, Anker SD, Solomon SD, Vardeny O, Michos ED, Fonarow GC, Butler J. Cardiovascular implications of COVID-19 versus influenza infection: a review. BMC Med. 2020;18(1):403.  https://doi.org/10.1186/s12916-020-01816-2
  5. Duffy EY, Cainzos-Achirica M, Michos ED. Primary and secondary prevention of cardiovascular disease in the era of the coronavirus pandemic. Circulation. 2020;141(24):1943-1945. https://doi.org/10.1161/CIRCULATIONAHA.120.047194
  6. Guo T, Fan Y, Chen M, Wu X, Zhang L, He T, Wang H, Wan J, Wang X, Lu Z. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(7):811-818.  https://doi.org/10.1001/jamacardio.2020.1017
  7. Atri D, Siddiqi HK, Lang JP, Nauffal V, Morrow DA, Bohula EA. COVID-19 for the cardiologist: basic virology, epidemiology, cardiac manifestations, and potential therapeutic strategies. JACC Basic Transl Sci. 2020; 5(5):518-536.  https://doi.org/10.1016/j.jacbts.2020.04.002
  8. Usman MS, Siddiqi TJ, Khan MS, Ahmed A, Ali SS, Michos ED, Hall ME, Krasuski RA, Greene SJ, Butler J, Alkhouli M. A Meta-analysis of the relationship between renin-angiotensin-aldosterone system inhibitors and COVID-19. Am J Cardiol. 2020;130:159-161.  https://doi.org/10.1016/j.amjcard.2020.05.038
  9. Minhas AS, Scheel P, Garibaldi B, Liu G, Horton M, Jennings M, Jones SR, Michos ED, Hays AG. Takotsubo syndrome in the setting of COVID-19. JACC Case Rep. 2020;2(9):1321-1325. https://doi.org/10.1016/j.jaccas.2020.04.023
  10. Fried JA, Ramasubbu K, Bhatt R, Topkara VK, Clerkin KJ, Horn E, Rabbani LR, Brodie D, Jain SS, Kirtane AJ, Masoumi A, Takeda K, Kumaraiah D, Burkhoff D, Leon M, Schwartz A, Uriel N, Sayer G. The variety of cardiovascular presentations of COVID-19. Circulation. 2020;141(23): 1930-1936. https://doi.org/10.1161/CIRCULATIONAHA.120.047164
  11. Dherange P, Lang J, Qian P, Oberfeld B, Sauer WH, Koplan B, Tedrow U. Arrhythmias and COVID-19: a review. JACC Clin Electrophysiol. 2020;6(9): 1193-1204. https://doi.org/10.1016/j.jacep.2020.08.002
  12. Castiello T, Georgiopoulos G, Finocchiaro G, Claudia M, Gianatti A, Delialis D, Aimo A, Prasad S. COVID-19 and myocarditis: a systematic review and overview of current challenges. Heart Fail Rev. 2021:1-11.  https://doi.org/10.1007/s10741-021-10087-9
  13. Puntmann VO, Carerj ML, Wieters I, Fahim M, Arendt C, Hoffmann J, Shchendrygina A, Escher F, Vasa-Nicotera M, Zeiher AM, Vehreschild M, Nagel E. Outcomes of cardiovascular magnetic resonance imaging in patients recently recovered from coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020;5(11):1265-1273. https://doi.org/10.1001/jamacardio.2020.3557
  14. Goerlich E, Minhas AS, Mukherjee M, Sheikh FH, Gilotra NA, Sharma G, Michos ED, Hays AG. Multimodality imaging for cardiac evaluation in patients with COVID-19. Curr Cardiol Rep. 2021;23(5):44.  https://doi.org/10.1007/s11886-021-01483-6
  15. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, White HD. The Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction Fourth universal definition of myocardial infarction (2018). Circulation. 2018;138(20):618-651.  https://doi.org/10.1161/CIR.0000000000000617
  16. Kwong JC, Schwartz KL, Campitelli MA, Chung H, Crowcroft NS, Karnauchow T, Katz K, Ko DT, McGeer AJ, McNally D, Richardson DC, Rosella LC, Simor A, Smieja M, Zahariadis G, Gubbay JB. Acute myocardial infarction after laboratory-confirmed influenza infection. N Engl J Med. 2018;378(4):345-353.  https://doi.org/10.1056/NEJMoa1702090
  17. Chapman AR, Bularga A, Mills NL. High-sensitivity cardiac troponin can be an ally in the fight against COVID-19. Circulation. 2020;141(22): 1733-1735. https://doi.org/10.1161/CIRCULATIONAHA.120.047008
  18. Jaffe AS, Cleland JGF, Katus HA. Myocardial injury in severe COVID-19 infection. Eur Heart J. 2020;41(22):2080-2082. https://doi.org/10.1093/eurheartj/ehaa447
  19. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, Gong W, Liu X, Liang J, Zhao Q, Huang H, Yang B, Huang C. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020;5(7):802-810.  https://doi.org/10.1001/jamacardio.2020.0950
  20. Shi S, Qin M, Cai Y, Liu T, Shen B, Yang F, Cao S, Liu X, Xiang Y, Zhao Q, Huang H, Yang B, Huang C. Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019. Eur Heart J. 2020;41(22):2070-2079. https://doi.org/10.1093/eurheartj/ehaa408
  21. Lippi G, Lavie CJ, Sanchis-Gomar F. Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): evidence from a meta-analysis. Prog Cardiovasc Dis. 2020;63(3):390-391.  https://doi.org/10.1016/j.pcad.2020.03.001
  22. Bavishi C, Bonow RO, Trivedi V, Abbott JD, Messerli FH, Bhatt DL. Special article — Acute myocardial injury in patients hospitalized with COVID-19 infection: a review. Prog Cardiovasc Dis. 2020;63(5):682-689.  https://doi.org/10.1016/j.pcad.2020.05.013
  23. Heffernan KS, Michos ED, Gump BB. Coronavirus disease 2019 (COVID-19) and cardiac injury. JAMA Cardiol. 2020;5:1198. https://doi.org/10.1001/jamacardio.2020.2450
  24. Lala A, Johnson KW, Januzzi JL, Russak AJ, Paranjpe I, Richter F, Zhao S, Somani S, Van Vleck T, Vaid A, Chaudhry F, De Freitas JK, Fayad ZA, Pinney SP, Levin M, Charney A, Bagiella E, Narula J, Glicksberg BS, Nadkarni G, Mancini DM, Fuster V; Mount Sinai COVID Informatics Center. Prevalence and impact of myocardial injury in patients hospitalized with COVID-19 infection. J Am Coll Cardiol. 2020;76(5):533-546.  https://doi.org/10.1016/j.jacc.2020.06.007
  25. Lombardi CM, Carubelli V, Iorio A, Inciardi RM, Bellasi A, Canale C, Camporotondo R, Catagnano F, Dalla Vecchia LA, Giovinazzo S, Maccagni G, Mapelli M, Margonato D, Monzo L, Nuzzi V, Oriecuia C, Peveri G, Pozzi A, Provenzale G, Sarullo F, Tomasoni D, Ameri P, Gnecchi M, Leonardi S, Merlo M, Agostoni P, Carugo S, Danzi GB, Guazzi M, la Rovere MT, Mortara A, Piepoli M, Porto I, Sinagra G, Volterrani M, Specchia C, Metra M, Senni M. Association of troponin levels with mortality in Italian patients hospitalized with coronavirus disease 2019: Results of a Multicenter Study. JAMA Cardiol. 2020;5(11):1274-1280. https://doi.org/10.1001/jamacardio.2020.3538
  26. Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, Butany J. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Investig. 2009;39(7):618-625.  https://doi.org/10.1111/j.1365-2362.2009.02153.x
  27. Xie J, Tong Z, Guan X, Du B, Qiu H. Clinical characteristics of patients who died of coronavirus disease 2019 in China. JAMA Netw Open. 2020;3(4): e205619. https://doi.org/10.1001/jamanetworkopen.2020.5619
  28. Tomasoni D, Inciardi RM, Lombardi CM, Tedino C, Agostoni P, Ameri P, Barbieri L, Bellasi A, Camporotondo R, Canale C, Carubelli V, Carugo S, Catagnano F, Dalla Vecchia LA, Danzi GB, di Pasquale M, Gaudenzi M, Giovinazzo S, Gnecchi M, Iorio A, la Rovere MT, Leonardi S, Maccagni G, Mapelli M, Margonato D, Merlo M, Monzo L, Mortara A, Nuzzi V, Piepoli M, Porto I, Pozzi A, Sarullo F, Sinagra G, Volterrani M, Zaccone G, Guazzi M, Senni M, Metra M. Impact of heart failure on the clinical course and outcomes of patients hospitalized for COVID-19. Results of the Cardio-COVID-Italy multicentre study. Eur J Heart Fail. 2020;22(12):2238-2247. https://doi.org/10.1002/ejhf.2052
  29. Hosseinzadeh R, Goharrizi M, Bahardoust M, Alvanegh AG, Ataee MR, Bagheri M, et al. Should all patients with hypertension be worried about developing severe coronavirus disease 2019 (COVID-19)? Clin Hypertens. 2021; 27(1):3.  https://doi.org/10.1186/s40885-021-00161-7
  30. Apicella M, Campopiano MC, Mantuano M, Mazoni L, Coppelli A, Del Prato S. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet Diabetes Endocrinol. 2020;8(9):782-792.  https://doi.org/10.1016/S2213-8587(20)30238-2
  31. Hendren NS, de Lemos JA, Ayers C, Das SR, Rao A, Carter S, Rosenblatt A, Walchok J, Omar W, Khera R, Hegde AA, Drazner MH, Neeland IJ, Grodin JL. Association of body mass index and age with morbidity and mortality in patients hospitalized with COVID-19: results from the American Heart Association COVID-19 Cardiovascular Disease Registry. Circulation. 2021;143(2):135-144.  https://doi.org/10.1161/CIRCULATIONAHA.120.051936
  32. Vorobeva OV, Lastochkin AV. Acute myocardial infarction and coronavirus infection (COVID-19). Infectious diseases: News, Opinions, Training. 2021; 10(36):93-97. (In Russ.). https://doi.org/10.33029/2305-3496-2021-10-1-93-97
  33. Vorobeva OV, Lastochkin AV. Organ-specific pathomorphological changes during COVID-19. Infection and Immunity. 2021;10(3):587-590. (In Russ.). https://doi.org/10.15789/2220-7619-PCI-1483
  34. Lindner D, Fitzek A, Brauninger H, Aleshcheva G, Edler C, Meissner K, Scherschel K, Kirchhof P, Escher F, Schultheiss HP, Blankenberg S, Püschel K, Westermann D. Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases. JAMA Cardiol. 2020;5(11):1281-1285. https://doi.org/10.1001/jamacardio.2020.3551
  35. Fox SE, Akmatbekov A, Harbert JL, Li G, Quincy Brown J, Vander Heide RS. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Lancet Respir Med. 2020;8(7):681-686.  https://doi.org/10.1016/S2213-2600(20)30243-5
  36. Bois MC, Boire NA, Layman AJ, Aubry MC, Alexander MP, Roden AC, Hagen CE, Quinton RA, Larsen C, Erben Y, Majumdar R, Jenkins SM, Kipp BR, Lin PT, Maleszewski JJ. COVID-19-associated nonocclusive fibrin microthrombi in the heart. Circulation. 2021;143(3):230-243.  https://doi.org/10.1161/CIRCULATIONAHA.120.050754
  37. Metkus TS, Sokoll LJ, Barth AS, Czarny MJ, Hays AG, Lowenstein CJ, Michos ED, Nolley EP, Post WS, Resar JR, Thiemann DR, Trost JC, Hasan RK. Myocardial injury in severe COVID-19 compared with non-COVID-19 acute respiratory distress syndrome. Circulation. 2021;143(6):553-565.  https://doi.org/10.1161/CIRCULATIONAHA.120.050543
  38. Sandoval Y, Januzzi JL Jr, Jaffe AS. Cardiac troponin for assessment of myocardial injury in COVID-19: JACC review topic of the week. J Am Coll Cardiol. 2020;76(10):1244-1258. https://doi.org/10.1016/j.jacc.2020.06.068
  39. Metkus TS, Guallar E, Sokoll L, Morrow D, Tomaselli G, Brower R, Schulman S, Korley FK. Prevalence and prognostic association of circulating troponin in the acute respiratory distress syndrome. Crit Care Med. 2017;45(10): 1709-1717. https://doi.org/10.1097/CCM.0000000000002641
  40. Metkus TS, Guallar E, Sokoll L, Morrow DA, Tomaselli G, Brower R, Kim BS, Schulman S, Korley FK. Progressive myocardial injury is associated with mortality in the acute respiratory distress syndrome. J Crit Care. 2018; 48:26-31.  https://doi.org/10.1016/j.jcrc.2018.08.009
  41. Masson S, Caironi P, Fanizza C, Carrer S, Caricato A, Fassini P, Vago T, Romero M, Tognoni G, Gattinoni L, Latini R, Albumin Italian Outcome Sepsis Study Investigators Sequential N-terminal pro-B-type natriuretic peptide and high-sensitivity cardiac troponin measurements during albumin replacement in patients with severe sepsis or septic shock. Crit Care Med. 2016;44(4):707-716.  https://doi.org/10.1097/CCM.0000000000001473
  42. Li D, Chen Y, Jia Y, Tong L, Tong J, Wang W, Liu Y, Wan Z, Cao Y, Zeng R. SARS-CoV-2-induced immune dysregulation and myocardial injury risk in China: insights from the ERS-COVID-19 study. Circ Res. 2020;127(3): 397-399.  https://doi.org/10.1161/CIRCRESAHA.120.317070
  43. Perez AL, Grodin JL, Chaikijurajai T, Wu Y, Hernandez AF, Butler J, Metra M, Felker GM, Voors AA, McMurray JJ, Armstrong PW, O’Connor C, Starling RC, Tang WHW. Interleukin-6 and outcomes in acute heart failure: an ASCEND-HF substudy. J Card Fail. 2021;27(6):670-676.  https://doi.org/10.1016/j.cardfail.2021.01.006
  44. Szekely Y, Lichter Y, Taieb P, Banai A, Hochstadt A, Merdler I, Gal Oz A, Rothschild E, Baruch G, Peri Y, Arbel Y, Topilsky Y. Spectrum of cardiac manifestations in COVID-19: a systematic echocardiographic study. Circulation. 2020;142(4):342-353.  https://doi.org/10.1161/CIRCULATIONAHA.120.047971
  45. Giustino G, Croft LB, Stefanini GG, Bragato R, Silbiger JJ, Vicenzi M, Danilov T, Kukar N, Shaban N, Kini A, Camaj A, Bienstock SW, Rashed ER, Rahman K, Oates CP, Buckley S, Elbaum LS, Arkonac D, Fiter R, Singh R, Li E, Razuk V, Robinson SE, Miller M, Bier B, Donghi V, Pisaniello M, Mantovani R, Pinto G, Rota I, Baggio S, Chiarito M, Fazzari F, Cusmano I, Curzi M, Ro R, Malick W, Kamran M, Kohli-Seth R, Bassily-Marcus AM, Neibart E, Serrao G, Perk G, Mancini D, Reddy VY, Pinney SP, Dangas G, Blasi F, Sharma SK, Mehran R, Condorelli G, Stone GW, Fuster V, Lerakis S, Goldman ME. Characterization of myocardial injury in patients with COVID-19. J Am Coll Cardiol. 2020;76(18):2043-2055. https://doi.org/10.1016/j.jacc.2020.08.069
  46. Goerlich E, Gilotra NA, Minhas AS, Bavaro N, Hays AG, Cingolani OH. Prominent longitudinal strain reduction of basal left ventricular segments in patients with coronavirus disease-19. J Card Fail. 2021;27(1):100-104.  https://doi.org/10.1016/j.cardfail.2020.09.469
  47. Smilowitz NR, Jethani N, Chen J, Aphinyanaphongs Y, Zhang R, Dogra S, Alviar CL, Keller N, Razzouk L, Quinones-Camacho A, Jung AS, Fishman GI, Hochman JS, Berger JS. Myocardial injury in adults hospitalized with COVID-19. Circulation. 2020;142(24):2393-2395. https://doi.org/10.1161/CIRCULATIONAHA.120.050434
  48. Qin JJ, Cheng X, Zhou F, Lei F, Akolkar G, Cai J, Zhang XJ, Blet A, Xie J, Zhang P, Liu YM, Huang Z, Zhao LP, Lin L, Xia M, Chen MM, Song X, Bai L, Chen Z, Zhang X, Xiang D, Chen J, Xu Q, Ma X, Touyz RM, Gao C, Wang H, Liu L, Mao W, Luo P, Yan Y, Ye P, Chen M, Chen G, Zhu L, She ZG, Huang X, Yuan Y, Zhang BH, Wang Y, Liu PP, Li H. Redefining cardiac biomarkers in predicting mortality of inpatients with COVID-19. Hypertension. 2020;76(4):1104-1112. https://doi.org/10.1161/HYPERTENSIONAHA.120.15528
  49. Couzin-Frankel J. The long haul. Science. 2020;369(6504):614-617.  https://doi.org/10.1126/science.369.6504.614
  50. Dani M, Dirksen A, Taraborrelli P, Torocastro M, Panagopoulos D, Sutton R, Lim PB. Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies. Clin Med. 2021;21(1):63-67.  https://doi.org/10.7861/clinmed.2020-0896
  51. Halpin SJ, McIvor C, Whyatt G, Adams A, Harvey O, McLean L, Walshaw C, Kemp S, Corrado J, Singh R, Collins T, O’Connor RJ, Sivan M. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: a cross-sectional evaluation. J Med Virol. 2021;93(2):1013-1022. https://doi.org/10.1002/jmv.26368
  52. Chopra V, Flanders SA, O’Malley M, Malani AN, Prescott HC. Sixty-day outcomes among patients hospitalized with COVID-19. Ann Intern Med. 2021;174(4):576-578.  https://doi.org/10.7326/M20-5661
  53. Carvalho-Schneider C, Laurent E, Lemaignen A, Beaufils E, Bourbao-Tournois C, Laribi S, Flament T, Ferreira-Maldent N, Bruyère F, Stefic K, Gaudy-Graffin C, Grammatico-Guillon L, Bernard L. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin Microbiol Infect. 2021;27(2):258-263.  https://doi.org/10.1016/j.cmi.2020.09.052
  54. Johansson M, Stahlberg M, Runold M, Nygren-Bonnier M, Nilsson J, Olshansky B, Bruchfeld J, Fedorowski A. Long-haul post-COVID-19 symptoms presenting as a variant of postural orthostatic Tachycardia syndrome: the Swedish experience. JACC Case Rep. 2021;3(4):573-580.  https://doi.org/10.1016/j.jaccas.2021.01.009

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