Ferroptosis in the reproductive system (a review)

Nikolaev A.A.; Kuznetsova M.G.

doi:https://doi.org/10.17116/repro20222805165

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Abstract:

This review considers the possibility of developing ferroptosis in the cells of the male reproductive system and the role of this biological process in impaired fertility Ferroptosis is a form of regulated cell deaths (RCD) characterized by iron-dependent accumulation of lipid peroxides. It differs morphologically and biochemically from the known types of cell death. Ferroptosis plays a vital role in the treatment of tumors, renal failure, and ischemic reperfusion injury (IRI). Inhibition of glutathione peroxidase 4 (GPX4), cysteine deficiency and peroxidation of arachidonic acid (AA) induce ferroptosis in cells. Iron chelators, lipophilic antioxidants and specific inhibitors suppress ferroptosis. Studies have shown the importance of ferroptosis in physiological and pathological processes in humans, its mechanism has not been sufficiently studied. The mechanisms of ferroptosis can be conditionally divided into two aspects: processes that promote the formation of lipid peroxides, and processes that suppress the restoration of lipid peroxides. The plasma membrane of mammalian spermatozoa is formed by high concentrations of polyunsaturated fatty acids, which makes it susceptible to lipid peroxidation, which leads to irreversible cell damage and can lead to infertility.

Keywords:

ferroptosis

lipid peroxidation

sperm

fertility

Authors:

Nikolaev A.A.

National University of Science and Technology «MISIS»

Kuznetsova M.G.

Astrakhan State Medical University of the Ministry of Health of the Russian Federation

Received:

13.09.2021

Accepted:

23.06.2022

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References:

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