The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Yakovlev I.B.

Mari State University, Republic of Mari El

Apryatina V.A.

Saint Petersburg Institute of Bioregulation and Gerontology

Petlenko S.V.

Golikov Research Clinical Center of Toxicology under the Federal Medical-Biological Agency

Drug-induced male infertility

Authors:

Yakovlev I.B., Apryatina V.A., Petlenko S.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(3): 110‑119

DOI: 10.17116/repro202228031110

Read: 29464 times

Download PDF (RU)
Contact the author
Table of contents

DRUG-INDUCED MALE INFERTILITY
DRUG-INDUCED MALE INFERTILITY

To cite this article:

Yakovlev IB, Apryatina VA, Petlenko SV. Drug-induced male infertility. Russian Journal of Human Reproduction. 2022;28(3):110‑119. (In Russ.)
https://doi.org/10.17116/repro202228031110

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Refe­rence value of the proportion of spermatozoa with fragmented DNA in the ejaculate of men from the North-Western region of Russia. Russian Journal of Human Reproduction. 2025;(1):94-104
Radi­cal cystectomy with fertility preservation for non-muscle inva­sive bladder cancer. P.A. Herzen Journal of Onco­logy. 2025;(2):76-82
The effect of sleep and other medi­cal and social factors on a woman’s reproductive function. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(5-2):81-86
Abstract:

This review discusses drug-induced disorders of male reproductive health. A systematic review of published information on the role of drugs used in clinical practice in the development of male infertility is presented. Information that is not provided in the approved instructions for medical use is included. Organizational and pharmacological solutions to the problem, non-specific and specific effects, such as the use of prostate extract in combination with zinc arginyl glycinate, are proposed.

Keywords:

male infertility
fertility
spermatogenesis
azoospermia
libido
prostate extract
zinc arginyl glycinate

Authors:

Yakovlev I.B.

Mari State University, Republic of Mari El

Apryatina V.A.

Saint Petersburg Institute of Bioregulation and Gerontology

Petlenko S.V.

Golikov Research Clinical Center of Toxicology under the Federal Medical-Biological Agency

Received:

04.04.2022

Accepted:

16.05.2022

Close metadata

References:

  1. Gosudarstvennyj reestr lekarstvennyh sredstv. Accessed February 04, 2022. (In Russ.). https://grls.rosminzdrav.ru/Default.aspx
  2. Medication, alcohol and smoking are the reality of risk factors. Akusherstvo i ginekologiya: Novosti. Mneniya. Obuchenie. 2014;3(5): 72-76. (In Russ.).
  3. Semet M, Paci M, Saïas-Magnan J, Metzler-Guillemain C, Boissier R, Lejeune H, Perrin J. The impact of drugs on male fertility: a review. Andrology. 2017;5(4):640-663.  https://doi.org/10.1111/andr.12366
  4. Ulstein M, Netto N, Leonard J, Paulsen CA. Changes in sperm morphology in normal men treated with danazol and testosterone. Contraception. 1975;12(4):437-444.  https://doi.org/10.1016/0010-7824(75)90079-7
  5. Ding J, Shang X, Zhang Z, Jing H, Shao J, Fei Q, Rayburn ER, Li H. FDA-approved medications that impair human spermatogenesis. Oncotarget. 2017;8(6):10714-10725. https://doi.org/10.18632/oncotarget.12956
  6. Maksimenya GG, Myatnikov AS. Adverse effects of drugs on male fertility. Medicinskij zhurnal. 2016;58(4):60-67. (In Russ.).
  7. Nilsson A, Nilsson S. Testicular germ cell tumors after clomiphene therapy for subfertility. The Journal of Urology. 1985;134(3):560-562.  https://doi.org/10.1016/s0022-5347(17)47294-6
  8. Amory JK, Wang C, Swerdloff RS, Anawalt BD, Matsumoto AM, Bremner WJ, Walker SE, Haberer LJ, Clark RV. Effect of 5alpha-reductase inhibition by dutasteride and finasteride on sperm parameters and serum hormones in healthy men. The Journal of Clinical Endocrinology and Metabolism. 2007;92(5):1659-1665. https://doi.org/10.1210/jc.2006-2203
  9. Mayer C, Adam M, Walenta L, Schmid N, Heikelä H, Schubert K, Flenkenthaler F, Dietrich KG, Gruschka S, Arnold GJ, Fröhlich T, Schwarzer JU, Köhn FM, Strauss L, Welter H, Poutanen M, Mayerhofer A. Insights into the role of androgen receptor in human testicular peritubular cells. Andrology. 2018;6(5):756-765.  https://doi.org/10.1111/andr.12509
  10. Schürmeyer T, Knuth UA, Belkien L, Nieschlag E. Reversible azoospermia induced by the anabolic steroid 19-nortestosterone. Lancet. 1984;8374(1):417-420.  https://doi.org/10.1016/s0140-6736(84)91752-5
  11. Drobnis EZ, Nangia AK. Psychotropics and Male Reproduction. Advances in Experimental Medicine and Biology. 2017;1034:63-101.  https://doi.org/10.1007/978-3-319-69535-8_8
  12. Hendrick V, Gitlin M, Altshuler L, Korenman S. Antidepressant medications, mood and male fertility. Psychoneuroendocrinology. 2000;25(1):37-51.  https://doi.org/10.1016/s0306-4530(99)00038-4
  13. Tanrikut C, Feldman AS, Altemus M, Paduch DA, Schlegel PN. Adverse effect of paroxetine on sperm. Fertility and Sterility. 2010; 94(3):1021-1026. https://doi.org/10.1016/j.fertnstert.2009.04.039
  14. Waldinger MD, Hengeveld MW, Zwinderman AH, Olivier B. Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. Journal of Clinical Psychopharmacology. 1998;18(4):274-281.  https://doi.org/10.1097/00004714-199808000-00004
  15. Husain AM, Carwile ST, Miller PP, Radtke RA. Improved sexual function in three men taking lamotrigine for epilepsy. Southern Medical Journal. 2000;93(3):335-336. 
  16. Drobnis EZ, Nangia AK. Immunosuppressants and Male Reproduction. Advances in Experimental Medicine and Biology. 2017;1034: 179-210.  https://doi.org/10.1007/978-3-319-69535-8
  17. Vinokurov AA, Novichkova GA, Rumyantsev AG. Prevention of male infertility in the treatment of tumors. Problems and Solutions. Rossijskij zhurnal detskoj gematologii i onkologii. 2015;2(4):42-50. (In Russ.). https://doi.org/10.17650/2311-1267-2015-2-4-42-50
  18. Ondrizek RR, Chan PJ, Patton WC, King A. An alternative medicine study of herbal effects on the penetration of zonafree hamster oocytes and the integrity of sperm deoxyribonucleic acid. Fertility and Sterility. 1999;71(3):517-22.  https://doi.org/10.1016/s0015-0282(98)00476-2
  19. Millsop JW, Heller MM, Eliason MJ, Murase JE. Dermatological medication effects on male fertility. Dermatologic Therapy. 2013; 26(4):337-346.  https://doi.org/10.1111/dth.12069
  20. Vawda AI, Davies AG. An investigation into the effects of ketoconazole on testicular function in Wistar rats. Acta Endocrinologica. 1986;111(2):246-251.  https://doi.org/10.1530/acta.0.1110246
  21. Bairy KL, Kumar G, Rao Y. Effect of acyclovir on the sperm parameters of albino mice. Indian Journal of Physiology and Pharmacology. 2009;53(4):327-333. 
  22. Movahed M, Sadrkhanlou D, Ahmadi A, Vahid Nejati V, Zamani Z. Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats. International Journal of Fertility and Sterility. 2013;7(1):49-56. 
  23. Pecou, S, Moinard N, Walschaerts M, Pasquier C, Daudin M, Bujan L. Ribavirin and pegylated interferon treatment for hepatitis C was associated not only with semen alterations but also with sperm deoxyribonucleic acid fragmentation in humans. Fertility and Sterility. 2009;91(3):933.e17-22.  https://doi.org/10.1016/j.fertnstert.2008.07.1755
  24. Narayana K, D’Souza UJ, Narayan P, Kumar G. The antiviral drug ribavirin reversibly affects the reproductive parameters in the male Wistar rat. Folia Morphologica. 2005;64(2):65-71. 
  25. McLeroth P, Paduch DA, Abt M, Hughes R, Moore S, Mudie N. Effects of valganciclovir on spermatogenesis in renal transplant patients — results of a multicenter prospective nonrandomized study. Transplant International. 2020;33(3):310-320.  https://doi.org/10.1111/tri.13558
  26. Wong PY, Lau SK, Fu WO. Antifertility effects of some sulphonamides and related compounds and their accumulation in the epididymides of male rats. Journal of Reproduction and Fertility. 1987; 81(1):259-267.  https://doi.org/10.1530/jrf.0.0810259
  27. Khaki A, Novin MG, Khaki AA, Nouri M, Sanati E, Nikmanesh M. Comparative study of the effects of gentamicin, neomycin, streptomycin and ofloxacin antibiotics on sperm parameters and testis apoptosis in rats. Pakistan Journal of Biological Sciences: PJBS. 2008; 11(13):1683-1689. https://doi.org/10.3923/pjbs.2008.1683.1689
  28. Hargreaves CA, Rogers S, Hills F, Rahman F, Howell RJ, Homa ST. Effects of co-trimoxazole, erythromycin, amoxycillin, tetracycline and chloroquine on sperm function in vitro. Human Reproduction. 1998;13(7):1878-1886. https://doi.org/10.1093/humrep/13.7.1878
  29. Shich EV, Machova AA, Mandych DV. Vliyanie lekarstvennyh sredstv na muzhskuyu fertil’nost’. M.: GEOTAR-Media; 2018. (In Russ.).
  30. Perez-Garcia LF, Dolhain RJEM, Vorstenbosch S, Bramer W, van Puijenbroek E, Hazes JMW, Te Winkel B. The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review. Human Reproduction Update. 2020;26(6):961-1001. https://doi.org/10.1093/humupd/dmaa022
  31. Toovey S, Hudson E, Hendry WF, Levi AJ. Sulphasalazine and male infertility: reversibility and possible mechanism. Gut. 1981;22(6): 445-451.  https://doi.org/10.1136/gut.22.6.445
  32. Kulchavenya EV, Osadchy AV. Influence of spermatoprotective therapy on ejaculate indicators at patients with prostatic tuberculosis. Journal of Siberian Medical Sciences. 2015;6:21. (In Russ.).
  33. Kanwar U, Anand RJ, Sanyal SN. The effect of nifedipine, a calcium channel blocker, on human spermatozoal functions. Contraception. 1993;48(5):453-470.  https://doi.org/10.1016/0010-7824(93)90135-t
  34. Goodwin LO, Leeds NB, Hurley I, Mandel FS, Pergolizzi RG, Benoff S. Isolation and characterization of the primary structure of testis-specific L-type calcium channel: implications for contraception. Molecular Human Reproduction. 1997;3(3):255-268.  https://doi.org/10.1093/molehr/3.3.255
  35. Agarwal A, Prabakaran SA, Said TM. Prevention of oxidative stress injury to sperm. Journal of Andrology. 2005;26(6):654-660.  https://doi.org/10.2164/jandrol.05016
  36. Smarr MM, Kannan K, Chen Z, Kim S, Buck Louis GM. Male urinary paracetamol and semen quality. Andrology. 2017;5(6):1082-1088. https://doi.org/10.1111/andr.12413
  37. Hamed SA. Sexual Dysfunctions Induced by Pregabalin. Clinical Neuropharmacology. 2018;41(4):116-122.  https://doi.org/10.1097/WNF.0000000000000286
  38. Sakr SA, Zoil Mel-S, El-Shafey SS. Ameliorative effect of grapefruit juice on amiodarone-induced cytogenetic and testicular damage in albino rats. Asian Pacific Journal of Tropical Biomedicine. 2013;3(7):573-579.  https://doi.org/10.1016/S2221-1691(13)60116-1
  39. Jackson H, Fox BW, Craig AW. The effect of alkylating agents on male rat fertility. British Journal of Pharmacology and Chemotherapy. 1959;14(2):149-157.  https://doi.org/10.1111/j.1476-5381.1959.tb01375.x
  40. Callis L, Nieto J, Vila A, Rende J. Chlorambucil treatment in minimal lesion nephrotic syndrome: a reappraisal of its gonadal toxicity. The Journal of Pediatrics. 1980;97(4):653-656.  https://doi.org/10.1016/s0022-3476(80)80035-7
  41. Padmanabhan S, Tripathi DN, Vikram A, Ramarao P, Jena GB. Cytotoxic and genotoxic effects of methotrexate in germ cells of male Swiss mice. Mutation Research. 2008;655(1-2):59-67.  https://doi.org/10.1016/j.mrgentox.2008.07.003
  42. Sussman A, Leonard JM. Psoriasis, methotrexate, and oligospermia. Archives of Dermatology. 1980;116(2):215-217. 
  43. Da Cunha MF, Meistrich ML, Fuller LM, Cundiff JH, Hagemeister FB, Velasquez WS, McLaughlin P, Riggs SA, Cabanillas FF, Salvador PG. Recovery of spermatogenesis after treatment for Hodgkin’s disease: limiting dose of MOPP chemotherapy. Journal of Clinical Oncology. 1984;2(6):571-577.  https://doi.org/10.1200/JCO.1984.2.6.571
  44. Bouchard P, Garcia E. Influence of testosterone substitution on sperm suppression by LHRH agonists. Hormone Research. 1987; 28(2-4):175-180.  https://doi.org/10.1159/000180942
  45. Keating GM. Triptorelin embonate (6-month formulation). Drugs. 2010;70(3):347-353.  https://doi.org/10.2165/11202230-000000000-00000
  46. Jagetia GC, Krishnamurthy H, Jyothi P. Evaluation of cytotoxic effects of different doses of vinblastine on mouse spermatogenesis by flow cytometry. Toxicology. 1996;112(3):227-236.  https://doi.org/10.1016/0300-483x(96)03402-6
  47. Hong CY, Chiang BN, Ku J, Wu P. Screening the in vitro sperm-immobilizing effect of some anticancer drugs. Human Toxicology. 1985;4(4):461-464.  https://doi.org/10.1177/096032718500400412
  48. Zuber J, Anglicheau D, Elie C, Bererhi L, Timsit MO, Mamzer-Bruneel MF, Ciroldi M, Martinez F, Snanoudj R, Hiesse C, Kreis H, Eustache F, Laborde K, Thervet E, Legendre C. Sirolimus may reduce fertility in male renal transplant recipients. American Journal of Transplantation. 2008;8(7):1471-1479. https://doi.org/10.1111/j.1600-6143.2008.02267.x
  49. Huyghe E, Zairi A, Nohra J, Kamar N, Plante P, Rostaing L. Gonadal impact of target of rapamycin inhibitors (sirolimus and everolimus) in male patients: an overview. Transplant International. 2007; 20(4):305-311.  https://doi.org/10.1111/j.1432-2277.2006.00423.x
  50. Pomara G, Morelli G, Canale D, Turchi P, Caglieresi C, Moschini C, Liguori G, Selli C, Macchia E, Martino E, Francesca F. Alterations in sperm motility after acute oral administration of sildenafil or tadalafil in young, infertile men. Fertility and Sterility. 2007; 88(4):860-865.  https://doi.org/10.1016/j.fertnstert.2006.12.019
  51. Hellstrom WJ, Gittelman M, Jarow J, Steidle C, McMurray J, Talley D, Watts S, Mitchell CL, McGill JM. An evaluation of semen characteristics in men 45 years of age or older after daily dosing with tadalafil 20mg: results of a multicenter, randomized, double-blind, placebo-controlled, 9-month study. European Urology. 2008;53(5): 1058-1065. https://doi.org/10.1016/j.eururo.2007.09.046
  52. Baza dannyh VOZ o pobochnyh effektah. Accessed February 04, 2022. (In Russ.). https://www.vigiaccess.org/
  53. Buhling K, Schumacher A, Eulenburg CZ, Laakmann E. Influence of oral vitamin and mineral supplementation on male infertility: a meta-analysis and systematic review. Reproductive Biomedicine Online. 2019;39(2):269-279.  https://doi.org/10.1016/j.rbmo.2019.03.099
  54. Vishvkarma R, Alahmar AT, Gupta G, Rajender S. Coenzyme Q10 effect on semen parameters: Profound or meagre? Andrologia. 2020;52(6):e13570. https://doi.org/10.1111/and.13570
  55. Cito G, Cocci A, Micelli E, Gabutti A, Russo GI, Coccia ME, Franco G, Serni S, Carini M, Natali A. Vitamin D and Male Fertility: An Updated Review. The World Journal of Men’s Health. 2020;38(2): 164-177.  https://doi.org/10.5534/wjmh.190057
  56. De Angelis C, Galdiero M, Pivonello C, Garifalos F, Menafra D, Cariati F, Salzano C, Galdiero G, Piscopo M, Vece A, Colao A, Pivonello R. The role of vitamin D in male fertility: A focus on the testis. Reviews in Endocrine and Metabolic Disorders. 2017;18(3):285-305.  https://doi.org/10.1007/s11154-017-9425-0
  57. Borovec SYu, Rybalov MA, Gorbachev AG, Al’-Shukri SH. Effect of prostatilen ac on sperm DNA fragmentation during treatment of patients with chronic nonbacterial prostatitis and concomitant disorders of the reproductive function. Andrologiya i genital’naya hirurgiya. 2017;18(3):54-58. (In Russ.). https://doi.org/10.17650/2070-9781-2017-18-3-54-58
  58. Zhukov OB, Evdokimov VV, Bragina EE. Improvement of quality of life and morphofunctional characteristics of spermatozoa in men with chronic nonbacterial prostatitis and in a program of preconception preparation to fatherhood. Andrologiya i genital’naya hirurgiya. 2017;18(1):102-108. (In Russ.). https://doi.org/10.17650/2070-9781-2017-18-1-102-108
  59. Yakovlev IB, Teplykh SV, Rybalov MA, Borovets SYu, Vasilyuk VB, Faraponova MV, Krasnov AA, Petlenko SV, Apryatina VA. Results of a clinical study of the efficacy and safety of prostate extract in combination with zinc arginyl glycinate in the correction of DNA fragmentation and oxidative activity of sperm plasma as factors of male infertility. Eksperimental’naya i klinicheskaya farmakologiya. 2022;85(2):11-15. (In Russ.). https://doi.org/10.30906/0869-2092-2022-85-2-11-15
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.