Unexplained female infertility and ART: clinic, embryology, genetic items

Zdanovskiy V.M.; Krasnopol’skaya K.V.; Lyakhov A.V.; Voskoboeva E.Y.

doi:https://doi.org/10.17116/repro20222802159

Zdanovskiy V.M.

Krasnopol’skaya K.V.

Moscow Regional Scientific Research Institute of Obstetrics and Gynecology;
M.F. Vladimirsky Moscow Regional Clinical Research Institute;
Prior Reproductive Health Clinic

ORCID: 0000-0002-1275-9220

Lyakhov A.V.

Moscow Region Research institute of obstetrics and gynecology

Voskoboeva E.Y.

Moscow Region Research institute of obstetrics and gynecology

Unexplained female infertility and ART: clinic, embryology, genetic items

Authors:

Zdanovskiy V.M., Krasnopol’skaya K.V., Lyakhov A.V., Voskoboeva E.Y.

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Journal: Russian Journal of Human Reproduction. 2022;28(2): 59‑67

DOI: 10.17116/repro20222802159

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To cite this article:

Zdanovskiy VM, Krasnopol’skaya KV, Lyakhov AV, Voskoboeva EY. Unexplained female infertility and ART: clinic, embryology, genetic items. Russian Journal of Human Reproduction. 2022;28(2):59‑67. (In Russ.)
https://doi.org/10.17116/repro20222802159

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)

Использование инфографики авторами научных работ

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OBJECTIVES

Causative Factors determination of ART failures during unexplained infertility treatment

MATERIALS AND METHODS

58 female unexplained infertility patients participated in the study (study group). 945 patients of the same age with well-established different diagnosis comprised the control group. ART treatment outcomes were evaluated in both groups. Next-generation sequencing (NGS) was used to determine the impact of genetics in (on) infertility etiology in 34 unexplained infertility women vs 50 controls.

RESULTS

Our data showed a significant decrease in average number of retrieved «mature» oocytes (MII), fertilization rate, and embryo transfer rate, accompanied by an essential increase in embryo segmentation and early (biochemical) pregnancy failure rate in unexplained infertility patients. NGS revealed genetic disturbances including point mutations — transitions and microdeletions in 19 of 34 (56%) patients of the study group.

CONCLUSION

According to the data obtained unexplained infertility prevalence appeared to be as low as 5.8% of total infertility group. Whereas clinical pregnancy rate was found to be extremely law among unexplained infertility patients. It could be probably (partly) explained by genetic disturbances (single nucleotide mutations, defects) affecting oocyte maturation and early embryo development. Thus low efficiency of ART (IVF) in unexplained infertility females at least (in more than a half) in a half of the patients could be due to genetic abnormalities. It seems reasonable to use individualized (case-by-case) approach to improve the situation of the low efficacy in IVF treatment among idiopathic infertility patient group.

Keywords:

Assisted reproductive technology (ART)

idiopathic infertility

unexplained infertility

reprogentics

in vitro fertilization (IVF)

early embryogenesis

oocyte maturation

Authors:

Zdanovskiy V.M.

Krasnopol’skaya K.V.

Moscow Regional Scientific Research Institute of Obstetrics and Gynecology;
M.F. Vladimirsky Moscow Regional Clinical Research Institute;
Prior Reproductive Health Clinic

ORCID: 0000-0002-1275-9220

Lyakhov A.V.

Moscow Region Research institute of obstetrics and gynecology

Voskoboeva E.Y.

Moscow Region Research institute of obstetrics and gynecology

Received:

14.02.2022

Accepted:

01.03.2022

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