The purpose of the study is to compare the effectiveness of IVF protocols with the use of corinollitropin alfa in women of advanced maternal age, depending on the ovarian reserve. Material and methods. Retrospective trial of infertile women (n=88) undergoing a single IVF/ICSI cycle with corifollitropin alfa. Depending on the age and state of the ovarian reserve, 3 groups of patients are formed. Group I (n=24) consisted of 37—42 years old women with a low ovarian reserve; group II (n=25) included patients of the same age with a normal ovarian reserve; the comparison group III (n=39) was formed from women 28—36 years with a normal ovarian reserve. Embryo transfer was performed in a fresh IVF cycle using GnRH antagonists protocols. Results. The duration of additional stimulation (from the 8th day of controlled ovarian stimulation) in I group was 6 (1—9), in II 3 (1—8) and in III 2 (1—4) days (pI—III = 0.016; pII—-III =0.171). The total dose of additional stimulation of r-FSH in I group was 1687 (275—2650), in II 675 (200—1950) and in III 450 (225—750) IU, (pI—III = 0.005; pII—III = 0.118). The dose of gonadotropins per 1 oocyte in group I was 1433 (748—2375), in II — 813 (506—900) and in III — 321 (192—386) IU (pI—III/pII—III <0.001). Percentage of mature oocytes (p=0.987) and fertilization rate (p=0.703) did not differ among groups. The frequency of biochemical pregnancy on ET in groups I, II, and III was 6.25, 25.5 and 36.4%, respectively (pI—III =0.037; pII—III = 0.548). The frequency of clinical pregnancies on ET in group I was 6.25%, in group II 17.6% and in group III 36.4% (pI—III = 0.037; pII—III =0.297). Conclusion. The use of fresh ET in the protocol with GnRH antagonists and coryphollitropin alfa is associated with the additional administration of high doses of r-FSH, furthermore the effectiveness of treatment remains extremely low. Reduced ovarian reserve is an equally important factor affecting the effectiveness of IVF programs in addition to the woman’s age.