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Gerasimov A.M.
Laboratory of Pathomorphology and Electron Microscopy, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia, Ivanovo, Russia
Malyshkina A.I.
FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii
Sotnikova N.Yu.
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Bogatova I.K.
Federal state budgetary institution «Ivanovo research institute motherhood and the childhood of V.N. Gorodkov» Ministries of Health of the Russia», Ivanovo, Russia
Martynchenko D.A.
Federal state budgetary institution «Ivanovo research institute motherhood and the childhood of V.N. Gorodkov» Ministries of Health of the Russia», Ivanovo, Russia
The role of the induced inflammatory-like reaction in a reproductive tract of woman during process of reproduction (a review)
Journal: Russian Journal of Human Reproduction. 2018;24(5): 20‑26
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To cite this article:
Gerasimov AM, Malyshkina AI, Sotnikova NYu, Bogatova IK, Martynchenko DA. The role of the induced inflammatory-like reaction in a reproductive tract of woman during process of reproduction (a review). Russian Journal of Human Reproduction.
2018;24(5):20‑26. (In Russ.)
https://doi.org/10.17116/repro20182405120
The article presents the data of recent studies showing the important mechanism supporting the reproductive processes is the development of an inflammatory-like reaction in the organs and tissues of the generative system. It is shown that the contact of the reproductive pathways of a woman with sperm leads to the certain changes in the cervical tissues and the mucous membrane of the uterus, which not only improves the receptivity of the endometrium and changes in the female immune system, but also contributes to the successful implantation and the subsequent normal course of pregnancy itself. Human seminal fluid contains a rich set of cytokines, chemokines and other cell-cell signaling factors. These biologically active substances can play a role in the formation of a postcoital inflammatory response in the genital tract of a woman. The application of local injury to the endometrium leads to the development of an inflammatory-like reaction in the tissues of the endometrium, somewhat similar to that of sperm. It is shown that endometrial biopsy significantly improves pregnancy success in patients undergoing IVF programs with previous implantation failures. However, up to the present time, the question of the appropriateness of using a local endometrial injury to improve implantation after embryo transfer in ART programs has been widely discussed in the literature and the data on this issue are contradictory and fragmented, and it is necessary to reveal markers for predicting the effectiveness of the scratching procedure. Prokineticin-1 is considered as one of the promising markers for predicting the successful completion of the ART procedure after the application of a local endometrial injury.
Authors:
Gerasimov A.M.
Laboratory of Pathomorphology and Electron Microscopy, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia, Ivanovo, Russia
Malyshkina A.I.
FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii
Sotnikova N.Yu.
Gorodkov Ivanovo Research Institute of Maternity and Childhood
Bogatova I.K.
Federal state budgetary institution «Ivanovo research institute motherhood and the childhood of V.N. Gorodkov» Ministries of Health of the Russia», Ivanovo, Russia
Martynchenko D.A.
Federal state budgetary institution «Ivanovo research institute motherhood and the childhood of V.N. Gorodkov» Ministries of Health of the Russia», Ivanovo, Russia
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