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Motrenko T.

Centre for Human Reproduction, GH"Danilo I", Cetinje, Montenegro

The risks of epigenetic reprogramming in children conceived by assisted reproductive technologies

Authors:

Motrenko T.

More about the authors

Journal: Russian Journal of Human Reproduction. 2016;22(4): 52‑59

Read: 4682 times


To cite this article:

Motrenko T. The risks of epigenetic reprogramming in children conceived by assisted reproductive technologies. Russian Journal of Human Reproduction. 2016;22(4):52‑59. (In Russ.)
https://doi.org/10.17116/repro201622452-59

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References:

  1. Horton TH. Fetal origins of developmental plasticity: animal models of induced life history variation. Am J Hum Biol. 2005 Jan-Feb;17(1):34-43. http://dx.doi.org/10.1002/ajhb.20092
  2. Crespi EJ, Denver RJ. Ancient origins of human developmental plasticity. Am J Hum Biol.2005 Jan-Feb;17(1):44-54.  http://dx.doi.org/10.1002/ajhb.20098
  3. Worthman CM, Kuzara J. Life history and early origins of health differentials. Am J Hum Biol.2005 Jan-Feb;17(1):95-112. http://dx.doi.org/10.1002/ajhb.20096 
  4. Barker DJ, Hales CN, Fall CH, Osmond C,Phipps K, Clark PM. Type 2 diebetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia. 1993 Jan;36(1):62-67. http://dx.doi.org/10.1007/bf00399095 
  5. Barker DJ. Fetal origins of coronary heart disease. BMJ 311,171-174. http://dx.doi.org/10.1136/bmj.311.6998.171 
  6. Gluckman PD, Hanson MA, Beedle AS. Early life events and their consequences for later disease: a life history and evolutionary perspective. Am J Hum Biol. 2007 Jan-Feb;19(1):1-19 http://dx.doi.org/10.1002/ajhb.20590 
  7. Nafee TM, Farrell WE, Carroll WD, Fryer AA, Ismail KMK. Epigenetic control of fetal gene expression. BJOG. 2008;115:158-168. http://dx.doi.org/10.1111/j.1471-0528.2007.01528.x 
  8. Giacobino AP, Chaillet JR. Genomic imprinting and assisted reproduction. Reproductive Health 2004;I:6. http://dx.doi.org/10.1186/1742-4755-1-6 
  9. Jones GM, Cram DS, Song B, Magli C, Gianaroli L, Kaplan OL, Findlay JK, Jenkin G, Trounson AO. Gene expression profiling of human oocytes following in vivo and in vitro maturation. Hum Reprod. 2008;23:5:1138-1144. http://dx.doi.org/10.1093/humrep/den085 
  10. Sato A, Otsu E, Negishi H, Utsunomiya T, Arima T. Aberrant DNA methylation of imprinted loci in superovulated oocytes. Hum Repr. 2007;22:1:26-35. http://dx.doi.org/10.1093/humrep/del316 
  11. Watkins AJ, Wilkins A, Cunningham C, Perry VH, Seet MJ, Osmond C, Eckert JJ, Torreens C, Cagampang FRA, Cleal J, Gray WP, Hanson MA, Fleming TP. Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. J Physiol. 2008 April 15;586:2231-2244. http://dx.doi.org/10.1113/jphysiol.2007.149229 
  12. Jacob S, Moley KH. Gametes and embryo epigenetic reprogramming affect developmental outcome: implication for assisted reproductive technologies. Pediatric Research. 2005;58:437-446. http://dx.doi.org/10.1203/01.pdr.0000179401.17161.d3
  13. Randhawa R, Cohen P. The role of insulin-like growth factor system in prenatal growth. Mol Genet Metab. 2005;86:84-90. http://dx.doi.org/10.1016/j.ymgme.2005.07.028 
  14. Fowden AL, Sibley C, Reik W, Constacia M. imprinted genes, placental development and fetal growth. Horm Res. 2006;65(Suppl.3):50-58. http://dx.doi.org/10.1159/000091506
  15. Watkins AJ, Platt D, Papenbrock T, Wilkins A, Eckert JJ, Kwong WY, Osmond C, Hanson M, Fleming TP. Mouse embryo culture induces changes in postnatal phenotype including raised systolic blood pressure. Proc Natl Acad Sci USA. 2007 March;104:5449-5454. http://dx.doi.org/10.1073/pnas.0610317104
  16. Gonzalez RF, Moreira P, Bilbao A, Jimenez A, Crespo MP, Ramirez MA, De Fonseca FR, Pintado B, Adan AG. Long term effect in vitro culture of mouse embryos with serum on mRNA expression of imprinted genes, development and behaviour. Proc Natl Acad Sci USA. 2004 April;101:5880-5888. http://dx.doi.org/10.1073/pnas.0308560101 
  17. Harvey AJ. The role of oxygen in ruminant preimplantation embryo development and metabolism. Anim Reprod Sci. 2007 Mar;98(1-2):113-128. http://dx.doi.org/10.1016/j.anireprosci.2006.10.008 
  18. Roseboom TJ, Van Der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Bleker OP. Adult survival after prenatal exposure to the Dutch famine 1944-1945. Pediatr Perinat Epidemol. 2001;15:220-225. http://dx.doi.org/10.1046/j.1365-3016.2001.00336.x 
  19. Zambrano E,Bautista CJ, Deas M, Martinez-Samayoa PM, Gonzales-Zamorano M, Ledesma H,Morales J, Larrea F, Nathanielsz PW. A low maternal protein diet during pregnancy and lactation has sex and window of exposure specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat. J Physiol. 2006 February 15;571:221-230. http://dx.doi.org/10.1113/jphysiol.2005.100313
  20. Stocker CJ, Arch JR, Cawthorne MA. Fetal origine of insulin resistance and obesity. Proc Nutr Soc. 2005 May;64(2):143-151. http://dx.doi.org/10.1079/pns2005417 
  21. Burdge GC, Slater-Jefferies J, Torrens C, Philips ES, Hanson MA, Lilycrop KA. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr. 2007 March;97(3):435-439. http://dx.doi.org/10.1017/s0007114507352392 
  22. Weaver IC. Epigenetic effects of glucocorticoids. Semin Fetal Neonatal Med. 2009 June;14(3):143-150. http://dx.doi.org/10.1016/j.siny.2008.12.002 
  23. Meaney MJ, Szyf M. Enviromental programming of stress responces through DNA methylation: life at interface between a dynamic environment and fixed genome. Dialogues Clin Neurosci. 2007;7(2):103-123.
  24. Owen D, Andrews MH, Matthews SG. Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour. Neurosci Biobehav Rev. 2005 Apr;29(2):209-226.
  25. Han HC, Austin KJ, Nathanielsz PW, Ford SP, Nijland MJ, Hansen TR. Maternal nutrient restriction alter gene expression in the ovine fetal heart. J Physiol. 2004 July 1;558(1):111-121. http://dx.doi.org/10.1113/jphysiol.2004.061697 
  26. Bertram C, Khan O, Ohri S, Philips DI, Matthews SG, Hanson MA. Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function. The Journal of Physiology 2008 April 1;586:2217-2229. http://dx.doi.org/10.1113/jphysiol.2007.147967 
  27. Crew D, Gore AC, Hsu TS, Nygerma LD, Spinetta M, Schallert T, Anway MD, Skinner MK. Transgenerational epigenetic imprints on mate preference. PNAS. 2007 February. http://dx.doi.org/10.1073/pnas.0610410104 
  28. Kobayashi H,Sato A, Otsu E, Hiura H, Tomatsu C, Utsunomiya T,et all. Aberant DNA methylation of imprinted loci in sperm from olygospermic patients. Hum Mol Genet. 2007;16(21):2542-2551. http://dx.doi.org/10.1093/hmg/ddm187 
  29. Lazaraviciute G, Kauser M, Bhattacharya S, Haggarty P and Bhattacharya. A systematic review and meta-analysis of DNA methylation levels and imprinting disorders in children conceived by IVF/ICSI compared with children conceived spontaneously. Human Reproduction Update. 2014;20:6:840-852. http://dx.doi.org/10.1093/humupd/dmv017 

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