Female reproductive system after the treatment of postcranial fossa tumors and leukemia in childhood

Gubernatorova E.E.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Pavlova M.G.

Kafedra éndokrinologii Pervogo MGMU im. I.M. Sechenova, Moskva

Melnichenko G.A.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia;
Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia

Kaznacheeva T.V.

Fakul'tet poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Mazerkina N.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko", Moskva

Sych Iu.P.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Zheludkova O.G.

GU FNKTs detskoĭ gematologii, onkologii i immunologii Minzdrava RF im. D. Rogacheva, Moskva

Tenedieva V.D.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Yudina A.E.

Sechenov First Moscow State Medical University, Moscow, Russia

Female reproductive system after the treatment of postcranial fossa tumors and leukemia in childhood

Authors:

Gubernatorova E.E., Pavlova M.G., Melnichenko G.A., Kaznacheeva T.V., Mazerkina N.A., Sych Iu.P., Zheludkova O.G., Tenedieva V.D., Yudina A.E.

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Journal: Russian Journal of Human Reproduction. 2013;(2): 37‑41

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To cite this article:

Gubernatorova EE, Pavlova MG, Melnichenko GA, et al. . Female reproductive system after the treatment of postcranial fossa tumors and leukemia in childhood. Russian Journal of Human Reproduction. 2013;(2):37‑41. (In Russ.)

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The treatment of postcranial fossa tumors and leukemia in childhood can affect reproductive system. Cranial irradiation may cause gonadotrophin deficiency while chemotherapy and spinal irradiation may lead to primary hypogonadism. Reproductive status of 32 female postcranial fossa tumors and leukemia survivals was assessed. Results of the study demonstrated the high prevalence of primary hypogonadism after the treatment. The signs of diminished ovarian reserve in this cohort of patients were found.

Keywords:

postcranial fossa tumors

leukemia

chemotherapy

spinal irradiation

hypogonadism

diminished ovarian reserv

Authors:

Gubernatorova E.E.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Pavlova M.G.

Kafedra éndokrinologii Pervogo MGMU im. I.M. Sechenova, Moskva

Melnichenko G.A.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia;
Endocrinology Research Center, Ministry of Health of Russia, Moscow, Russia

Kaznacheeva T.V.

Fakul'tet poslediplomnogo obrazovaniia Moskovskogo gosudarstvennogo mediko-stomatologicheskogo universiteta

Mazerkina N.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko", Moskva

Sych Iu.P.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova

Zheludkova O.G.

GU FNKTs detskoĭ gematologii, onkologii i immunologii Minzdrava RF im. D. Rogacheva, Moskva

Tenedieva V.D.

NII neĭrokhirurgii im. N.N. Burdenko RAMN, Moskva

Yudina A.E.

Sechenov First Moscow State Medical University, Moscow, Russia

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