The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Avzaletdinova D.S.

Bashkir State Medical University, Ufa, Russia

Kochetova O.V.

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, Ufa, Russia

Sharipova L.F.

Bashkir State Medical University, Ufa, Russia

Morugova T.V.

State budgetary educational institution of additional professional education «Bashkir State Medical University», Russian Ministry of Health, Ufa, Russia

Mustafina O.E.

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, Ufa, Russia

Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan

Authors:

Avzaletdinova D.S., Kochetova O.V., Sharipova L.F., Morugova T.V., Mustafina O.E.

More about the authors

Journal: Problems of Endocrinology. 2019;65(1): 31‑38

DOI: 10.14341/probl9426

Views: 1292

Downloaded: 7

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Avzaletdinova DS, Kochetova OV, Sharipova LF, Morugova TV, Mustafina OE. Association of adiponectin gene alleles with type 2 diabetes mellitus in residents of Bashkortostan. Problems of Endocrinology. 2019;65(1):31‑38. (In Russ.)
https://doi.org/10.14341/probl9426

МСФ на ЯМ
Close metadata
Recommended articles:
Obesity grade I: a study of real clinical practice in the Russian Fede­ration. Medi­cal Technologies. Asse­ssment and Choice. 2024;(1):83-90
Oxidative stress prevention as an effe­ctive preventive stra­tegy in type 2 diabetes mellitus. Russian Journal of Preventive Medi­cine. 2024;(3):117-123
Dyna­mics of outpatient glycemic profile data in patients with type 2 diabetes receiving dietary fiber. Russian Journal of Evidence-Based Gastroenterology. 2024;(2):55-65
Pecu­liarities of local mRNA gene expression of pro- and anti-inflammatory cyto­kines in term pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2024;(3):6-13
Macrovascular and microvascular complications of type 2 diabetes mellitus. Russian Journal of Preventive Medi­cine. 2024;(8):94-100
Clinical consequences of sarcopenic obesity. Part 1. Non-alcoholic fatty liver disease, type 2 diabetes mellitus, chro­nic kidney disease. Russian Journal of Preventive Medi­cine. 2024;(8):114-120
Continuum of type 2 diabetes mellitus and its como­rbidity with other soma­tic diseases. Russian Journal of Preventive Medi­cine. 2024;(9):123-129
Modu­lation of oxidative stress as an early symptom of sarcopenia in type 2 diabetes mellitus. Russian Journal of Preventive Medi­cine. 2024;(10):108-116
Deve­lopment of a first LAMP kit for measles diagnostics. Labo­ratory Service. 2024;(4):28-35

Type 2 diabetes mellitus (T2DM) is one of the most acute problems of the modern world. The disease is characterized by high ratio of micro- and macrovascular complications. T2DM is a multifactorial and polygenic disease, structure of hereditary predisposition to which may be population-specific. Aim — the analysis of allelic associations of adiponectin gene (ADIPOQ, rs17366743) with T2DM, its clinical and metabolic characteristics and complications in T2DM patients resident in the Republic of Bashkortostan. Material and methods. 3 PCR-based method of genotyping with polymorphic marker rs17366743 of ADIPOQ gene in 433 T2DM patients and 428 healthy controls, residents of Bashkortostan. Results. The ratio of genotype CT and allele C was higher in T2DM patients compared with controls (15.7% vs. 6.8%; p=0.0002 and 7.8% vs. 3.4%; p<0.0001, respectively). Genotype TT and allele T were less frequent in T2DM than in healthy subjects (84.3 and 93,2%; p=0.0002; 92.2 and 96.6%, p<0.0001, respectively). The association with the development of diabetic retinopathy and cataract was shown (p=0,044, p=0,008, respectively). Conclusions. Allele C and genotype CT are risk markers of T2DM (OR=2.43 and 2.56 respectively).

Keywords:

diabetes mellitus type 2
adiponectin gene ADIPOQ
rs17366743 polymorphism
polymerase chain reaction

Authors:

Avzaletdinova D.S.

Bashkir State Medical University, Ufa, Russia

Kochetova O.V.

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, Ufa, Russia

Sharipova L.F.

Bashkir State Medical University, Ufa, Russia

Morugova T.V.

State budgetary educational institution of additional professional education «Bashkir State Medical University», Russian Ministry of Health, Ufa, Russia

Mustafina O.E.

Institute of Biochemistry and Genetics of Ufa Scientific Centre of the Russian Academy of Sciences, Ufa, Russia

List of references:

  1. Ruan H, Dong LQ. Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol. 2016;8(2):101-109. https://doi.org/10.1093/jmcb/mjw014
  2. Kadowaki T, Yamauchi T, Kubota N, et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7):1784-1792. https://doi.org/10.1172/jci29126
  3. Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T. Adiponectin receptors: a review of their structure, function and how they work. Best Pract Res Clin Endocrinol Metab. 2014;28(1):15-23. https://doi.org/10.1016/j.beem.2013.09.003
  4. Hui E, Xu A, Chow WS, et al. Hypoadiponectinemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study. Metab Syndr Relat Disord. 2014;12(10):517-522. https://doi.org/10.1089/met.2014.0024
  5. Matsuzawa Y. Establishment of a concept of visceral fat syndrome and discovery of adiponectin. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):131-141. https://doi.org/10.2183/pjab.86.131
  6. Xu A, Vanhoutte PM. Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am J Physiol Heart Circ Physiol. 2012;302(6):H1231-H1240. https://doi.org/10.1152/ajpheart.00765.2011
  7. Wang Y, Zhang D, Liu Y, et al. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. J Genet Genomics. 2009;36(7):417-423. https://doi.org/10.1016/s1673-8527(08)60131-9
  8. Warren LL, Li L, Nelson MR, et al. Deep resequencing unveils genetic architecture of ADIPOQ and identifies a novel low-frequency variant strongly associated with adiponectin variation. Diabetes. 2012;61(5):1297-1301. https://doi.org/10.2337/db11-0985
  9. Heid IM, Wagner SA, Gohlke H, et al. Genetic architecture of the APML gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1727 healthy caucasians. Diabetes. 2006;55(2):375-384. https://doi.org/10.2337/diabetes.55.02.06.db05-0747
  10. Hivert MF, Manning AK, Mcateer JB, et al. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 2008;57(12):3353-3359. https://doi.org/10.2337/db08-0700
  11. Tsai MK, Wang HM, Shiang JC, et al. Sequence variants of ADIPOQ and association with type 2 diabetes mellitus in Taiwan Chinese Han Population. Scientific World Journal. 2014;2014:650393. https://doi.org/10.1155/2014/650393
  12. Du W, Li Q, Lu Y, et al. Genetic variants in ADIPOQ gene and the risk of type 2 diabetes: a case-control study of Chinese Han Population. Endocrine. 2011;40(3):413-422. https://doi.org/10.1007/s12020-011-9488-8
  13. Ramya K, Ayyappa KA, Ghosh S, et al. Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in South Indian Population. Gene. 2013;532(2):253-262. https://doi.org/10.1016/j.gene.2013.09.012
  14. Chu H, Wang M, Zhong D, et al. ADIPOQ polymorphisms are associated with type 2 diabetes mellitus: a metaanalysis study. Diabetes Metab Res Rev. 2013;29(7):532-545. https://doi.org/10.1002/dmrr.2424
  15. Han LY, Wu QH, Jiao ML, et al. Associations between single-nucleotide polymorphisms (+45t>G, +276g>T, –11377c>G, –11391g>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and metaanalysis. Diabetologia. 2011;54(9):2303-2314. https://doi.org/10.1007/s00125-011-2202-9
  16. Tanimura D, Shibata R, Izawa H, et al. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese Population. Eur J Hum Genet. 2011;19(3):262-269. https://doi.org/10.1038/ejhg.2010.201
  17. Vasseur F. Single-nucleotide polymorphism haplotypes in the both proximal promoter and EXON 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet. 2002;11(21):2607-2614. https://doi.org/10.1093/hmg/11.21.2607
  18. Alekseeva LL, Ignatyev PM, Osakovsky VL, et al. Association of polymorphic markers of adiponectine gene with diabetic retinopathy at type 2 diabetes mellitus in the Yakuts. Yakut Medical Journal. 2011;1:37-40. (In Russ.)
  19. Smetnev SA, Meshkov AN. The role of peptide hormones (adiponectin, leptin, insulin) in the pathogenesis of atherosclerosis. Rational Pharmacotherapy in Cardiology. 2015;11(5):522-528. (In Russ.)
  20. Babak OYa, Klimenko NN. Physiological and pathophysiological roles of adiponectin in the integrated regulation of metabolic and cardiovascular diseases. Ukrainian Therapeutic Journal. 2010;2:94-100. (In Russ.)
  21. Hotta K, Funahashi T, Bodkin NL, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes. 2001;50(5):1126-1133. https://doi.org/10.2337/diabetes.50.5.1126
  22. Schwarz PE, Govindarajalu S, Towers W, et al. Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian Population. Horm Metab Res. 2006;38(7):447-451. https://doi.org/10.1055/s-2006-947842
  23. Isakova ZhT, Lunegova OS, Talaibekova ET, et al. Association of adiponectin gene G276t polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients. Ter Arkh. 2015;87(10):85-90. (In Russ.) https://doi.org/10.17116/terarkh2015871085-90
  24. Ghoshal K, Bhattacharyya M. Adiponectin: probe of the molecular paradigm associating diabetes and obesity. World J Diabetes. 2015;6(1):151-166. https://doi.org/10.4239/wjd.v6.i1.151
  25. Rohde K, Keller M, Horstmann A, et al. Role of genetic variants in ADIPOQ in human eating behavior. Genes Nutr. 2015;10(1):449. https://doi.org/10.1007/s12263-014-0449-8
  26. Gu HF, Abulaiti A, Ostenson CG, et al. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians. Diabetes. 2004;53(Supplement 1):S31-S35. https://doi.org/10.2337/diabetes.53.2007.s31
  27. Hara K, Boutin P, Mori Y, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese Population. Diabetes. 2002;51(2):536-540. https://doi.org/10.2337/diabetes.51.2.536
  28. Khodyrev DS, Nikitin AG, Brovkin AN, et al. Association of polymorphisms of the ADIPOQ, ADIPOR1 and ADIPOR2 genes with type 2 diabetes mellitus. Diabetes Mellitus. 2015;18(2):5-11. (In Russ.) https://doi.org/10.14341/dm201525-11
  29. Potapov VA, Chistiakov DA, Dubinina A, et al. Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Rev Diabet Stud. 2008;5(1):28-37. https://doi.org/10.1900/rds.2008.5.28
  30. Filippi E, Sentinelli F, Trischitta V, et al. Association of the human adiponectin gene and insulin resistance. Eur J Hum Genet. 2004;12(3):199-205. https://doi.org/10.1038/sj.ejhg.5201120

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.