The new immunological methods for diagnostics of type 1 autoimmune polyendocrine syndrome (the first experience in Russia)

Sozaeva L.S.; Karmanov M.E.; Breivik L.; Husbi E.; Kareva M.A.

doi:https://doi.org/10.14341/probl20156134-8

Sozaeva L.S.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Karmanov M.E.

RDKB

Breivik L.

University of Bergen, Norway

Husbi E.

University of Bergen, Norway

Kareva M.A.

Institut detskoĭ éndokrinologii Éndokrinologicheskogo nauchnogo tsentra, Moskva

The new immunological methods for diagnostics of type 1 autoimmune polyendocrine syndrome (the first experience in Russia)

Authors:

Sozaeva L.S., Karmanov M.E., Breivik L., Husbi E., Kareva M.A.

More about the authors

Journal: Problems of Endocrinology. 2015;61(3): 4‑8

DOI: 10.14341/probl20156134-8

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To cite this article:

Sozaeva LS, Karmanov ME, Breivik L, Husbi E, Kareva MA. The new immunological methods for diagnostics of type 1 autoimmune polyendocrine syndrome (the first experience in Russia). Problems of Endocrinology. 2015;61(3):4‑8. (In Russ.)
https://doi.org/10.14341/probl20156134-8

Использование инфографики авторами научных работ

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Abstract:

This study was designed to ascertain the role of anti-interferon (IFN)-ω and -α2 antibodies (AB) in diagnostics of type 1 autoimmune polyglandular syndrome (APS-1) and evaluate specificity and sensitivity of the HEK-Blue cells method used to detect these antibodies. The study included 34 patients presenting with APS-1 and 21 patients with focal alopecia. All 100% of the patients with APS-1 ehxhibited high titers of anti IFN-ω antibodies; 97% of them had anti IFN-a2 antibodies. These antibodies were not found in the patients with focal alopecia. It is concluded that the measurement of anti IFN-α and α2 antibodies with the use of HEK-Blue cells is a highly specific and sensitive method for diagnostics of APS-1.

Keywords:

type 1 autoimmune polyglandular syndrome

alopecia

thymoma

interferon -ω and α2

HEK-Blue cells method

Authors:

Sozaeva L.S.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Karmanov M.E.

RDKB

Breivik L.

University of Bergen, Norway

Husbi E.

University of Bergen, Norway

Kareva M.A.

Institut detskoĭ éndokrinologii Éndokrinologicheskogo nauchnogo tsentra, Moskva

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