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Eremina I.A.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Kuraeva T.L.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

The use of metformin for the treatment of type 2 diabetes mellitus in children and adolescents

Authors:

Eremina I.A., Kuraeva T.L.

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Journal: Problems of Endocrinology. 2013;59(1): 8‑13

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THE USE OF METFORMIN FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS IN CHILDREN AND ADOLESCENTS
THE USE OF METFORMIN FOR THE TREATMENT OF TYPE 2 DIABETES MELLITUS IN CHILDREN AND ADOLESCENTS

To cite this article:

Eremina IA, Kuraeva TL. The use of metformin for the treatment of type 2 diabetes mellitus in children and adolescents. Problems of Endocrinology. 2013;59(1):8‑13. (In Russ.)

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Abstract:

The increasingly higher incidence of type 2 diabetes mellitus (DM2) in the children and adolescent populations implies the necessity of analysis of the effectiveness of currently available therapeutic modalities bearing in mind more aggressive specific complications of the disease in these groups of patients compared with the adult ones. Metformin is the sole oral hypoglycemic agent approved for the use in the children and adolescents with DM2. This paper reports the results of the application of different therapeutic modalities with the use of metformin in the children and adolescents with DM2.

Keywords:

type 2 diabetes mellitus
children and adolescents
metformin

Authors:

Eremina I.A.

FGBU "Éndokrinologicheskiĭ nauchnyĭ tsentr" Minzdrava RF, Moskva

Kuraeva T.L.

FGU Éndokrinologicheskiĭ nauchnyĭ tsentr Minzdravsotsrazvitiia Rossiĭskoĭ Federatsii, Moskva

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References:

  1. Swift P.G. Diabetes education. ISPAD Clinical Practice Consensus Guidelines 2006-2007. Pediat Diabet 2007; 8: 102-109.
  2. Zimmet P., Alberti K.G., Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001; 414: 782-787.
  3. Peterkova V.A., Kuraeva T.L., Remizov O.V., Shcherbacheva L.N. Izuchenie faktorov riska, razrabotka metodov diagnostiki i lecheniya sakharnogo diabeta 2-go tipa u detei i podrostkov moskovskoi populyatsii. Metodicheskie rekomendatsii. M 2004; 12.
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  7. Pavkov M.E., Bennett P.H., Knowler W.C., Krakoff J., Sievers M.L., Nelson R.G. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA 2006; 296: 4: 421-426.
  8. Fagot-Campagna A., Pettitt D.J., Engelgau M.M., Burrows N.R., Geiss L.S., Valdez R., Beckles G.L., Saaddine J., Gregg E.W., Williamson D.F., Narayan K.M. Type 2 diabetes among North American children and adolescents: an epidemiological review and public health perspective. J Pediatr 2000; 136: 664-672.
  9. Salpeter S.R., Greyber E., Pasternak G.A., Salpeter E.E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 2003; 24: 163, 2594-2602.
  10. Peterkova V.A. Glyukofazh v lechenii sakharnogo diabeta 2-go tipa u detei i podrostkov. Farmateka 2008; 17: 171: 61-63.
  11. Jones K.L., Arslanian S., Peterkova V.A., Park J.S., Tomlinson M.J. Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial. Diabet Care 2002; 25: 1: 89-94.
  12. Laffel L., Chang N., Grey M., Hale D., Higgins L., Hirst K., Izquierdo R., Larkin M., Macha C., Pham T., Wauters A., Weinstock R.S. TODAY Study Group. Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study. Pediatr Diabet 2012; 13: 369-375.
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