Effect of platelet-rich plasma on skin quality in patients with involution of the neck area

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OBJECTIVE

To analyze clinical and morphological effects of platelet-rich plasma (PRP) on the neck skin quality.

MATERIAL AND METHODS

Each out of 4 patients received 3 injections (1 injection every 4 weeks) into the neck area (PRP 2.5 ml on the right and saline solution 2.5 ml on the left). The results were evaluated considering clinical and instrumental data (standardized photos, Wrinkle Severity Rating Scale (WSRS), Neck Skin Laxity (NSL) Scale, Antera 3D camera with large texture filter) separately for the right and left sides of the neck. Moreover, a 58-year-old woman underwent skin punch biopsy in the right and left behind-the-ear areas in 3 weeks after injections. Light and transmission electron microscopy of specimens was performed.

RESULTS

Clinical and objective parameters of the neck skin in 2 weeks after injections demonstrated moderate positive effect of PRP on the wrinkle depth, density and texture of skin. Histological study revealed higher functional activity of fibroblasts accompanied by development of new collagen fibrils, destructively altered myofibroblasts, as well as angiogenesis in deep dermal layers and subcutaneous fatty tissue on the side of PRP injections. There were significantly fewer functionally active fibroblasts on the side of saline injections; fibrocytes and cells with various degrees of destruction prevailed.

CONCLUSION

PRP has a positive effect on clinical and structural characteristics of skin. PRP therapy can be used for anti-aging correction of skin in various parts of the body.

Keywords:

PRP therapy

neck rejuvenation

morphological examination of skin

electron microscopy of skin

myofibroblasts

collagen

angiogenesis

Authors:

Sharova A.A.

Center for Aesthetic Medicine «Chistye Prudy»

Chekmareva I.A.

Vishnevsky National Medical Research Center of Surgery

ORCID: 0000-0003-0126-4473

Agapova M.A.

Swiss Center for Rejuvenation “Versua Clinic”

Received:

23.09.2021

Accepted:

04.10.2021

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