The paper presents the results of medical, surgical, and multimodality treatments for different forms of human papillomavirus (HPV)-associated uterine cervical pathology in 244 patients. There is evidence for active approaches to managing patients with mild HPV-associated lesions in the presence of the columnar epithelium, which could eliminate HPV in 72.97±0.85% of cases. It has been proposed to complement systemic immunotherapy with IFN-α2b to an electrosurgical method, which could achieve HPV elimination in patients with CIN2-3 and Stage IA1 stage uterine cervical cancer by 20% more frequently. Criteria have been proposed for the choice of the optimal treatment option in terms of the degree of the disease, the histological features of the cervical epithelium, and the level of viral load in order not only to remove a pathological focus, but also to eliminate the virus, which allows reductions in the risk of disease recurrence and progression.