One of the urgent problem of modern dermatocosmetology is the development of highly effective and safe methods of acne therapy.

THE PURPOSE

Study of the clinical efficacy, safety of use and mechanisms of therapeutic action of cold atmospheric plasma in treatment of patients with acne.

MATERIAL AND METHODS

The studies were conducted in 75 acne patients aged 16 to 25 years. Patients were randomized into 3 groups of 25 people each. Patients of the 1st group received monotherapy with cold atmospheric plasma, in the 2nd group external agents were used: adapalene, benzoyl peroxide and clindamycin, patients of the 3rd group were prescribed complex therapy with cold atmospheric plasma and external agents. In patients of group 1, before and after treatment, species and quantitative composition of skin microflora, intensity of sebum production, state of microvasculature, and degree of hydration and pH of skin were studied.

RESULTS

The positive effect of treatment was noted of majority of patients. Clinical manifestations of disease were most quickly relive with complex therapy. In patients of 1st group, after a course of monotherapy with cold atmospheric plasma, disappearance of corynobacteria, green streptococcus, non-fermenting gram-negative bacteria and yeast-like fungi from the skin was observed; the number of Propionibacterium acnes decreased more than 3 times, Staphylococcus aureus and Staphylococcus epidermidis — more than 2 times. In addition, use of cold atmospheric plasma contributed to a decrease in sebum production, normalization of passive blood flow and decrease skin pH.

CONCLUSION

Clinical effectiveness of acne treatment with cold atmospheric plasma is due to its ability to eliminate pathogenic and conditionally pathogenic flora, reduce sebum production, improve the state of the microvasculature, and restore subacidic skin pH. Complex acne therapy, including the use of cold atmospheric plasma and external agents, is characterized by significant clinical efficacy and high level of safety.