Laboratory diagnosis of syphilis: current priorities

Dmitriev G.A.; Frigo N.V.; Negasheva E.S.; Rotanov S.V.; Kitaeva N.V.; Dolia O.V.

doi:https://doi.org/10.17116/klinderma202019021154

Dmitriev G.A.

Pervyĭ MGMU im. I.M. Sechenova

Frigo N.V.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

ORCID: 0000-0001-6231-971X

Negasheva E.S.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Rotanov S.V.

Pirogov Russian National Research Medical University, Moscow, Russia, 117997

Kitaeva N.V.

Moscow Scientic and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia

Dolia O.V.

I.M. Sechenov First Moscow State Medical University

Laboratory diagnosis of syphilis: current priorities

Authors:

Dmitriev G.A., Frigo N.V., Negasheva E.S., Rotanov S.V., Kitaeva N.V., Dolia O.V.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(2): 154‑161

DOI: 10.17116/klinderma202019021154

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To cite this article:

Dmitriev GA, Frigo NV, Negasheva ES, Rotanov SV, Kitaeva NV, Dolia OV. Laboratory diagnosis of syphilis: current priorities. Russian Journal of Clinical Dermatology and Venereology. 2020;19(2):154‑161. (In Russ.)
https://doi.org/10.17116/klinderma202019021154

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

Relevance. Due to the variety of symptoms and often hidden course, laboratory diagnostics occupies an important place in the clinical algorithm for managing patients with syphilitic infection. This is especially true for one of the most difficult for the diagnosis and treatment of the form of the disease — neurosyphilis. Discussion. A comparative analysis of the laboratory diagnostic methods for syphilis was performed: dark field microscopy (DFM), polymerase chain reaction (PCR), precipitin test (MR, or RMP, RPR, VDRL), passive hemagglutination (TPHA), enzyme-linked immunosorbent assay (ELISA), treponema pallidum immobilization test (TPIT, or TPI), immunofluorescence test (FTA) and its modifications (FTA-ABS, FTA-200, FTA-C), immunoblotting, as well as new methodologies: serum-liquor ratio (ITPA index), immunochip, multivariate discriminant analysis (MDA) method. Recommendations on their use are given. Conclusion. Priorities for the use of modern laboratory tests for syphilis are noted. The positive results of the use of laboratory tests not regulated in Russia and approaches to the diagnosis of neurosyphilis (ITPA index, VDRL — test of the Venereal Disease Research Laboratory, related to nontreponemal tests, immunochip, multivariate discriminant analysis method) were ascertained, which in the future are supposed to replace some of the currently used methodologies.

Keywords:

syphilis

neurosyphilis

diagnostics

nontreponemal tests

treponemal tests

serum-cerebrospinal fluid ratio

multivariate discriminant analysis

Authors:

Dmitriev G.A.

Pervyĭ MGMU im. I.M. Sechenova

Frigo N.V.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

ORCID: 0000-0001-6231-971X

Negasheva E.S.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Rotanov S.V.

Pirogov Russian National Research Medical University, Moscow, Russia, 117997

Kitaeva N.V.

Moscow Scientic and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia

Dolia O.V.

I.M. Sechenov First Moscow State Medical University

Close metadata

References:

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