Rosacea is a common skin disease that develops as a result of chronic recurrent vascular disorder of the facial skin. This disease accounts for up to 5% of all dermatoses and it is the seventh most common dermatose. There are more than 45 million patients with rosacea. The disease affects the social behavior of a person, because its manifestations affect the face, which dramatically reduces patient’s quality of life and causes various of psycho-emotional disorders. Objective — the study was aimed at investigating clinical and epidemiological features of rosacea as exemplified by the contingent of the outpatient Clinic №1 of the Administrative Department of the President of the Russian Federation and assessing the efficacy and tolerability of medications containing 1% Chrysanthelium indicum extract in the complex treatment of patients with rosacea. Material and methods. The study included 41 patients aged 28—69 years with mild, moderate, and severe forms of erythematous-telangiectatic and papulopustular rosacea. Depending on the therapy, the patients were divided into three groups: group 1 patients received systemic therapy with doxycycline according to the conventional regimen and topical treatment with 1% metronidazole cream; group 2 patients (n=12) received systemic and topical treatment with metronidazole according to the conventional regimen; group 3 patients (n=14) received topical treatment with 1% metronidazole cream. Additionally, all groups of patients received a cream containing 1% Chrysanthelium extract. The effectiveness of therapy was assessed against a 4-point severity scale, which was used to evaluate manifestations, such as xerosis, facial edema, itchiness, erythema, telangiectasia, papules, and pustules. The evaluation was carried out before treatment and 4, 8, and 12 weeks after initiation of treatment. Results. Most often, the disease occurred in females over the age of 35 years with a second skin phototype, combined or normal skin type. The most common triggering factors included weather, nutrition, heavy physical exertion, emotional stress, and high ambient temperature. The drug products containing 1% Chrysanthelium indicum extract in combination with conventional therapy demonstrated good effect: decrease in itchiness by 80%, xerosis — by 70%, erythema — 65.7%, telangiectasia — 18.2%, papules and pustules — 76.5%, and edema — 66.7%. Conclusion. These data suggest that drug products containing 1% Chrysanthelium indicum extract can be recommended for application in combination therapy of rosacea and in patients predisposed to rosacea to protect against ultraviolet irradiation.