Aging in general, and age-related changes in the facial skin in particular are the important problem of modern dermatology and cosmetology. By now, microcirculation disturbances have been found to play an important role in the pathogenesis of skin aging. One of the modern methods to study microcirculation in clinical practice is laser Doppler flowmetry (LDF). The aim of the study was to determine the informative content of the LDF method for evaluating the efficacy of correction of age-related facial skin changes using ultraphonophoresis of Longidaza. Material and methods. The study included 48 females aged 45 to 55 years. All patients underwent ultraphonophoresis with Longidaza 3000 IU. Ultrasound therapy was carried out at the frequency of 2640 kHz in the continuous mode with the intensity of 0.2—0.4 W/cm2. It was applied to three facial skin areas (cheeks and forehead), 3 min per area, daily, 10 procedures in total. The condition of capillary blood flow was assessed based on the LDF data using a LAKK-01 capillary blood flow laser analyzer (LAZMA, Russia). Results. Using the LDF method, the results indicating pathological changes in the microcirculation system of the facial skin (as age increases) in females were obtained. In this case, the nature of detected disturbances allowed allocating them to three groups: patients with a hyperemic type of microcirculation (group A), with a spastic type (group B), and with a normal circulatory type (group C). Application of ultraphonophoresis of a complex proteolytic enzyme (Longidaza) has a positive effect on the microcirculation condition both in hyperemic and in spastic hemodynamic types. Therefore, LDF is a new non-invasive method to assess the microcirculation condition, the higher informative content of which can be an objective criterion of the efficacy of physiotherapy in cosmetology and dermatology.