Tinea (dermatomycosis) is an infection of the skin or its appendages caused by microscopic filamentous fungi known as dermatophytes. Dermatophytes are able to invade and reproduce in keratinized tissues, i.e. in the skin, hair and nails. Tineas, more commonly caused by anthropophilic fungi, are characterized by persistent chronic course. Despite the fact that this pathology is one of the most frequent reasons for reference to dermatologists, there has been an increase in the incidence of dermatomycoses and changes in the nature of their course in recent years worldwide, including in presence of comorbidity. Resistance to antifungal drugs can be enhanced by recurrent tineas, which lead to the emergence of new refractory strains. Considering that a limited number of antimycotics is available for the treatment of superficial fungal infections, special attention in real-life clinical practice should be paid to certain strategies, such as the use of modern formulations of antifungal agents, molecules combining antimycotic, antibacterial and/or anti-inflammatory activity as well as combinations of topical antifungal drugs for achievement of synergistic action against dermatomycoses. We present a series of clinical cases devoted to the rational selection of topical therapy for dermatomycoses in real-life clinical practice and the search for possible strategies of combined local treatment.