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Seksyaev N.E.

Academician Ye.A. Vagner Perm State Medical University, Perm, Russia;
Perm Regional Clinical Infectious Diseases Hospital, Perm, Russia

Karakulova Yu.V.

Academician Ye.A. Vagner Perm State Medical University, Perm, Russia

Vychugzhanina A.A.

Academician Ye.A. Vagner Perm State Medical University, Perm, Russia

Antiretroviral therapy-associated polyneuropathy in patients with HIV infection

Authors:

Seksyaev N.E., Karakulova Yu.V., Vychugzhanina A.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(4): 28‑34

DOI: 10.17116/jnevro202612604128

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Table of contents

ANTIRETROVIRAL THERAPY-ASSOCIATED POLYNEUROPATHY IN PATIENTS WITH HIV INFECTION
ANTIRETROVIRAL THERAPY-ASSOCIATED POLYNEUROPATHY IN PATIENTS WITH HIV INFECTION

To cite this article:

Seksyaev NE, Karakulova YuV, Vychugzhanina AA. Antiretroviral therapy-associated polyneuropathy in patients with HIV infection. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;126(4):28‑34. (In Russ.)
https://doi.org/10.17116/jnevro202612604128

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This paper reviews the issue of polyneuropathy caused by antiretroviral therapy (ART), which has dramatically changed the outcomes of human immunodeficiency virus (HIV) infection, significantly increasing the life expectancy of patients, and reducing the frequency of opportunistic infections. Long-term use of ART is associated with many complications, with polyneuropathy occupying a special place and accounting for 20—50% of all ART complications. Polyneuropathy is manifested by symmetrical distal sensory impairments combined with neuropathic pain, which significantly reduces the quality of life of patients and can reduce compliance to treatment. The article presents the key features of differential diagnosis of ART-associated, HIV-associated, and chemotherapy-induced polyneuropathies; their main pathogenetic features are described and the options for prevention and treatment of ART- associated polyneuropathy are analyzed.

Keywords:

antiretroviral therapy-associated polyneuropathy
HIV infection
chemotherapy-induced polyneuropathy

Authors:

Seksyaev N.E.

Academician Ye.A. Vagner Perm State Medical University, Perm, Russia;
Perm Regional Clinical Infectious Diseases Hospital, Perm, Russia

Karakulova Yu.V.

Academician Ye.A. Vagner Perm State Medical University, Perm, Russia

Vychugzhanina A.A.

Academician Ye.A. Vagner Perm State Medical University, Perm, Russia

Received:

11.11.2025

Accepted:

11.12.2025

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