Полинейропатия, ассоциированная с антиретровирусной терапией у пациентов с ВИЧ-инфекцией

Авторы:

Никита Евгеньевич Сексяев,

Юлия Владимировна Каракулова,

Анна Андреевна Вычугжанина

Журнал: Журнал неврологии и психиатрии им. С.С. Корсакова. 2026;126(4):28-34.

DOI: 10.17116/jnevro202612604128

Прочитано: 609 раз

Резюме

Обзор посвящен актуальной теме полинейропатии, вызванной приемом препаратов антиретровирусной терапии (АРТ), которая кардинально изменила исходы инфицирования вирусом иммунодефицита человека (ВИЧ), значительно увеличив продолжительность жизни пациентов и снизив частоту оппортунистических инфекций. Длительное применение АРТ связано с возникновением множества осложнений, среди которых полинейропатия занимает особое место, достигая частоты 20—50% среди всех осложнений АРТ. Клинически полинейропатия проявляется симметричными дистальными сенсорными нарушениями в сочетании с нейропатическим болевым синдромом, что существенно снижает качество жизни пациентов и может уменьшать приверженность лечению. В статье представлены ключевые особенности дифференциальной диагностики АРТ-индуцированной, ВИЧ-ассоциированной и химио-индуцированной полинейропатий; рассмотрены их основные патогенетические особенности; проанализированы возможности профилактики и лечения АРТ-индуцированной полинейропатии.

Ключевые слова

полинейропатия
ассоциированная с антиретровирусной терапией
ВИЧ-инфекция
химио-индуцированная полинейропатия

Дата поступления: 11.11.2025

Дата принятия в печать: 11.12.2025

Дата публикации: 14.05.2026

Литература / References

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Полинейропатия, ассоциированная с антиретровирусной терапией у пациентов с ВИЧ-инфекцией

Резюме

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