Azelaic acid in dermatological and cosmetological practice

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The data of foreign and Russian clinical studies on the efficacy and safety of azelaic acid (AA) in treatment of acne and rosacea in dermatological and cosmetological practice are presented. The review focuses on acne pathogenesis and analyzes the factors responsible for predisposition to development of severe chronic forms of the disease. Recommendations for managing patients with acne depending on type and severity of the pathological process are also provided; the recommendations are based of modern Russian and foreign guidelines. The data of comparative studies of the effectiveness of AA and other topical medications are also presented. The advantages of using combination therapy to treat acne and rosacea are presented: in particular, those of a combination of AA with topical retinoids, benzoyl peroxide, topical and systemic antibiotics. Reliable performance, safety, suitability for long-term therapy and high compliance rate make AA the optimal topical treatment for acne, rosacea and cosmetic problems associated with these diseases.

Keywords:

acne

rosacea

treatment

topical therapy

azelaic acid

combination therapy

Authors:

Matushevskaia E.V.

FGOU Institut povysheniia kvalifikatsii Federal'nogo mediko-biologicheskogo agentstva RF, Moskva

Svirshchevskaia E.V.

Institut bioorganicheskoĭ khimii im. M.M. Shemiakina i Iu.A. Ovchinnikova RAN, Moskva, 117997, Rossiĭskaia Federatsiia

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