Psoriasis is an immune-mediated disease with genetic predisposition to its development. It is known that the immunopathological processes in this disease are systemic and involve mechanisms of cell-mediated and humoral immunity. In recent years, researchers believe that psoriasis is an independent risk factor for cardiovascular diseases in patients of all ages and is associated with lipid metabolism disorders at the very beginning of the disease, especially in overweight patients. Some studies point out the existence of common mechanisms for the development of systemic inflammation in psoriasis and atherosclerosis. However, it remains unclear whether it is a single process or different mutually exacerbating pathological conditions. Objective. To study the levels of cytokines, cholesterol, and the body mass index and to find correlations between these parameters in patients with psoriasis vulgaris. Material and methods. A retrospective analysis of data from clinical and laboratory studies of 29 patients diagnosed with moderate and moderate to severe psoriasis vulgaris was conducted, including the study of gender-age structure, comorbidities, body mass index (BMI), serum cholesterol level, blood cytokines IFN-, IFN-, IL-1, IL-4, IL-6, IL-8 level, as well as their correlation interactions. Results. Normal body weight was found in 27.5% of the 29 patients with psoriasis, pre-obesity - in 38%, class I and II obesity - in 31 and 3.5% of patients, respectively. Elevated cholesterol level was detected in 14 (48%) patients; its combination with pre-obesity or obesity was observed in this subgroup of patients. An increase in IFN- and IL-1 levels in subgroups with pre-obesity and class I and II obesity as compared to those in patients with normal body weight was revealed. The IFN- level was significantly higher in women than that in men (9.5 and 1.5 pg/l, respectively, p<0.05). Conclusions. The tendency toward increase in cholesterol level, along with increase in the degree of obesity was observed in patients with moderate to severe psoriasis. This fact is indicative of the risk of atherosclerotic processes and comorbid cardiovascular pathology. Meanwhile, the serum cholesterol level shows no correlation with BMI, age and weight of psoriasis patients. Patients with psoriasis and high BMI have higher serum levels of IL-1 and IFN- as compared to patients with psoriasis and normal body weight and BMI, which indicates that these cytokines are involved in formation of systemic inflammatory response (SIR). Positive correlation between BMI and IL-1 level is indicative of the severity of SIR in patients with abdominal obesity. Negative correlation between IL-6 level and BMI suggests the opposite participation of this cytokine in the development of SIR in psoriasis patients.