The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Kalinin A.G.

A.A. Vishnevsky National Medical Research Center of High Medical Technologies

Pilat T.L.

Research Institute of Occupational Medicine named after Academician N.F. Izmerov

Alekhnovich A.V.

Russian Medical Academy of Continuous Professional Education

Sukhorukov A.L.

A.A. Vishnevsky National Medical Research Center of High Medical Technologies

Evaluation of the effectiveness of perioperative nutritional metabolic support in surgical patients with combined trauma involving the gastrointestinal tract

Authors:

Kalinin A.G., Pilat T.L., Alekhnovich A.V., Sukhorukov A.L.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2025;(12): 131‑146

DOI: 10.17116/hirurgia2025121131

Read: 358 times

Buy for 300₽
Contact the author
Table of contents

EVALUATION OF THE EFFECTIVENESS OF PERIOPERATIVE NUTRITIONAL METABOLIC SUPPORT IN SURGICAL PATIENTS WITH COMBINED TRAUMA INVOLVING THE GASTROINTESTINAL TRACT
EVALUATION OF THE EFFECTIVENESS OF PERIOPERATIVE NUTRITIONAL METABOLIC SUPPORT IN SURGICAL PATIENTS WITH COMBINED TRAUMA INVOLVING THE GASTROINTESTINAL TRACT

To cite this article:

Kalinin AG, Pilat TL, Alekhnovich AV, Sukhorukov AL. Evaluation of the effectiveness of perioperative nutritional metabolic support in surgical patients with combined trauma involving the gastrointestinal tract. Pirogov Russian Journal of Surgery. 2025;(12):131‑146. (In Russ.)
https://doi.org/10.17116/hirurgia2025121131

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Evaluation of perioperative correction of nutritional defi­ciency in patients with complicated forms of esophageal and gastric cancer. Piro­gov Russian Journal of Surgery. 2025;(6):78-88
Taeniasis and appe­ndicitis: a rare para­sitic connection. Piro­gov Russian Journal of Surgery. 2025;(12):147-150
Gut—brain: inte­ractions in health and pathology. Russian Journal of Preventive Medi­cine. 2025;(11):106-112
Abstract:

OBJECTIVE

To evaluate the efficacy, safety, and tolerability of nutritional metabolic support (NMS) in surgical patients with polytrauma involving the gastrointestinal tract, as well as to analyze its impact on the postoperative period.

MATERIAL AND METHODS

Eighty patients with gastrointestinal tract trauma were included in the study using an open randomization method. Most patients were in a serious or moderate condition. Twenty patients in the first main group received the «Protein Detoxification Cocktail» (PDC), and those in the second main group received the «Protein Recovery Cocktail» (PRC), one serving twice daily. The third main group included 20 patients with polytrauma who received one serving of PDC in the morning and one serving of PRC in the evening (PDC+PRC) for 21 days. Twenty patients in the control group did not receive additional NMS. Anthropometric parameters, laboratory data, and questionnaire data were assessed on Day 1 of the study and after 21 days.

RESULTS

The studied enteral metabolic nutrition reduced gastrointestinal and metabolic disorders, normalized body weight, increased blood levels of total protein and albumin, improved markers of intoxication and inflammation, enhanced wound healing, increased vital energy, accelerated the recovery of patients’ quality of life, and significantly improved overall condition. The medical nutrition did not cause intolerance or allergic reactions. Patients did not refuse to take it and consumed the entire servings.

CONCLUSION

The study demonstrated the high clinical efficacy of the metabolic enteral nutrition products in the perioperative period. The enteral nutrition developed In Russia ensures technological sovereignty and import substitution.

Keywords:

polytrauma
gastrointestinal tract
medical nutrition
efficacy and safety

Authors:

Kalinin A.G.

A.A. Vishnevsky National Medical Research Center of High Medical Technologies

Pilat T.L.

Research Institute of Occupational Medicine named after Academician N.F. Izmerov

Alekhnovich A.V.

Russian Medical Academy of Continuous Professional Education

Sukhorukov A.L.

A.A. Vishnevsky National Medical Research Center of High Medical Technologies

Received:

10.09.2025

Accepted:

14.10.2025

Close metadata

References:

  1. Khabriev RU, Cherkasov SN, Egiazaryan KA, Attaeva LZh. Current state of the problem of traumatism. Problems of Social Hygiene, Healthcare, and the History of Medicine. 2017;25(1):4-7. (In Russ.). https://doi.org/10.18821/0869-866X-2017-25-1-4-7
  2. Samusenko DV, Erokhin AN, Martel II. The problem of diagnosis of traumatic disease and conditions for its solution. Polytrauma. 2012;4:69-72. (In Russ.).
  3. Zarubina IV, Yunusov IA, Shabanov PD. Antioxidant effects of metabolic protectors in experimental traumatic toxicosis. Medical-biological and socio-psychological problems of safety in emergency situations. 2010;3:69-72. (In Russ.).
  4. Zarubina IV. Metabolic correction of multiple organ failure in the early period of traumatic toxicosis. Reviews of clinical pharmacology and drug therapy. 2012;10(4):3-15. (In Russ.).
  5. Povzun SA. Pathophysiological mechanisms of crush syndrome (first message). Emergency medical care. 2015;16(4):46-52. (In Russ.).
  6. Ma XY, Xiao Y, Chen T, et al. Predictive value of combining of anatomy scoring system and physiological scoring system for the diagnosis of multiple organ dysfunction syndrome in patients with severe trauma. Zhonghua Shao Shang ZaZhi. 2016;32(2):105-108. 
  7. Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315 (8):801-810. 
  8. Viktorova SV, Akhtyamova IF, Bakhtiozin AV, Grigoriev AI. Statistics of venous thromboembolic complications in patients of intensive care units of a multidisciplinary hospital. In the collection: Modern aspects of traumatology, orthopedics and reconstructive surgery. Astrakhan, 2017. (In Russ.).
  9. Irzin KS. Correction of endogenous intoxication using efferent detoxification methods. Medical Journal of Western Kazakhstan. 2012;3(35):145-146. (In Russ.).
  10. Ursova NI. The place of enterosorbents in the therapy of endogenous intoxication syndrome. VSP. 2012;6:26-31. (In Russ.).
  11. Khoroshilov SE, Nikulin AV. Efferent treatment of critical conditions. General Reanimatology. 2012;VIII(4):30-41. (In Russ.). https://doi.org/10.15360/1813-9779-2012-4-30
  12. Evstigneeva IS. Multidisciplinary approach to medical rehabilitation of patients with breast cancer. National Oncology Program. 2030;1:2023. (In Russ.).
  13. Orlov YuP, Lukach VN, Glushchenko AV. Reamberin in the intensive care program for patients with widespread peritonitis. News of surgery. 2013;21(5):58-64. (In Russ.).
  14. Srubilin DV, Enikeev DA, Myshkin VA. Pathogenetic substantiation of the use of low-intensity laser radiation and a complex compound of succinic acid with 5-hydroxy-6-methyluracil in experimental peritonitis. Fundamental research. 2013;21(5):58-64. (In Russ.).
  15. Pilat TL, Kuzmina LP, Izmerova NI. Detoxification nutrition. M.: GEOTAR-Media, 2012. (In Russ.).
  16. Sologub TV, Goryacheva LG, Sukhanov DS, et al. Hepatoprotective activity of remaxol in chronic liver damage (materials of a multicenter randomized placebo-controlled study). Clinical Medicine. 2010;1:62-66. (In Russ.).
  17. Odinak MM, Yanishevsky SN, Tsygan NV, et al. Use of succinates for correction of metabolic disorders in the ischemic penumbra zone in patients with stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(12-2):55-60. (In Russ.).
  18. Gnezdilova AV, Lebedeva MA, Ganshina TS, et al. Mexidol and combined vascular pathology of the brain and heart. Experimental and clinical pharmacology. 2011;74(6):20-23. (In Russ.).
  19. Lyang OV, Kochetov AG. Use of Mexidol in cerebral ischemia. S.S. Korsakov Journal of Neurology and Psychiatry. 2013;113(12):126-129. (In Russ.).
  20. Smirnov AV, Nesterova OB, Golubev RV. Succinic acid and its use in medicine. Nephrology. 2014;18(2):33-41. (In Russ.).
  21. Pilat TL, Moroz EV, Fateev AV. Therapeutic restorative nutrition for combined trauma. Medical Bulletin of the Main Military Clinical Hospital named after N.N. Burdenko. 2023;3. (In Russ.).
  22. Daikhes NA, Pilat TL, Vinogradov VV, et al. Nutritional detoxification support in ENT oncology. Practical oncology. 2020;21(3):262-268. (In Russ.). https://doi.org/10.31917/2103262
  23. Daikhes NA, Pilat TL, Burkin AV, et al. The effectiveness of specialized detoxification nutrition for cancers. PA. Herzen Journal of Oncology=Onkologiya. Zhurnal imeni PA. Gertsena. 2020;9(6):59-66. (In Russ.). https://doi.org/10.17116/onkolog2020906159
  24. Pilat TL. Specialized dietary food products in oncological practice. Meditsinskiy sovet=Medical Council. 2020;(20):111-117. (In Russ.). https://doi.org/10.21518/2079-701X-2020-20-111-117
  25. Pilat TL, Khanferyan RA. Efficiency of detoxifying specialized nutrition in oncological diseases. Pharmateka. 2021;7:61-66. (In Russ.).
  26. Evstigneeva IS. The impact of medical rehabilitation on improving the quality of life of patients with malignant neoplasm of the breast in the early postoperative period. Doctor. 2022;33(9):83-90. (In Russ.). https://doi.org/10.29296/25877305-2022-09-17
  27. Detoxification Nutrition for Cancer Patients. Medical Forum. V Anniversary International Forum of Oncology and Radiotherapy «For Life.» Effective Pharmacotherapy. 2022;18(35):12-14. (In Russ.).
  28. Stalnaya ID, Garishvili TT. Method for determination of malonic dialdehyde using thiobarbituric acid. Modern methods in biochemistry. M.: Medicine, 1977. (In Russ.).
  29. Korolyuk MA, Ivanova LI, Mayorova IG, Tokarev VE. Method for determining catalase activity.. Laboratory work. 1988;1:16-19. (In Russ.).
  30. Ostrovsky VK, Semenova OP, Mashchenko AV, et al. Some data on the normal values of the leukocyte intoxication index. Clinical laboratory diagnostics. 2003;1:45-46. (In Russ.).
  31. Sidelnikova VI. Endogenous intoxication and inflammation: sequence of reactions and informativeness of markers (review). Biology. 2015;50(2):152-161. (In Russ.).
  32. Titov VN, Krylin VV. Stress, chaperone proteins, disruption of the biological function of endoecology and biological reactions of excretion, inflammation and blood pressure. Clinical laboratory diagnostics. 2010;5:20-36. (In Russ.).
  33. Webber M, Krishnan A, Thomas NG, Cheung BM. Association between serum alkaline phosphatase and C-reactive protein in the United States National Health and Nutrition Examination Survey 2005—2006. Clinical Chemistry and Laboratory Medicine. 2010;48(2):167-173.  https://doi.org/10.1515/cclm.2010.052
  34. Kunutsor SK, Bakker SJL, KootstraRos JE, et al. Serum alkaline phosphatase and risk of incident cardiovascular disease: interrelationship with high sensitivity C-reactive protein. PLoSOne. 2015;10(7):e0132822. https://doi.org/10.1371/journal.pone.0132822
  35. Loskutova EE, Kurashov MM, Radysh IV, et al. Clinical and economic analysis of the use of products for enteral nutrition. Medical Council. 2023;17(22):102-109. (In Russ.). https://doi.org/10.21518/ms2023-445
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.