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Rzaeva K.A.

Almazov National Medical Research Center

Manukyan S.N.

Meshalkin National Medical Research Center

Gorbatykh A.V.

Almazov National Medical Research Center

Zhuravleva I.Yu.

Meshalkin National Medical Research Center

Vladimirov S.V.

Meshalkin National Medical Research Center

Soynov I.A.

Meshalkin National Medical Research Center

Implantation of transcatheter self-expanding valve through hybrid approach: acute experiment on a large animal model

Authors:

Rzaeva K.A., Manukyan S.N., Gorbatykh A.V., Zhuravleva I.Yu., Vladimirov S.V., Soynov I.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2025;(11): 73‑78

DOI: 10.17116/hirurgia202511173

Read: 484 times

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Table of contents

IMPLANTATION OF TRANSCATHETER SELF-EXPANDING VALVE THROUGH HYBRID APPROACH: ACUTE EXPERIMENT ON A LARGE ANIMAL MODEL
IMPLANTATION OF TRANSCATHETER SELF-EXPANDING VALVE THROUGH HYBRID APPROACH: ACUTE EXPERIMENT ON A LARGE ANIMAL MODEL

To cite this article:

Rzaeva KA, Manukyan SN, Gorbatykh AV, Zhuravleva IYu, Vladimirov SV, Soynov IA. Implantation of transcatheter self-expanding valve through hybrid approach: acute experiment on a large animal model. Pirogov Russian Journal of Surgery. 2025;(11):73‑78. (In Russ.)
https://doi.org/10.17116/hirurgia202511173

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

OBJECTIVE

To evaluate the properties of original transcatheter self-expanding pulmonary artery valve and to perform implantation in vivo on a large laboratory animal.

MATERIAL AND METHODS

A healthy 8-month-old female white pig weighing 66 kg underwent acute experimental procedure. Original transcatheter valve was implanted via left-sided minithoracotomy using hybrid surgical approach.

RESULTS

Immediate results revealed optimal angiographic and hemodynamic characteristics: normal closure, native pulmonary leaflets covered by the implanted bioprosthesis, no deformity of valve framework and intact pulmonary artery wall. There were no tricuspid obstruction and pressure gradient.

CONCLUSION

Implantation of original transcatheter pulmonary artery valve in a porcine experiment demonstrated its immediate efficacy and safety without the risk of pulmonary artery perforation or displacement.

Keywords:

transcatheter implantation
self-opening
frame
development

Authors:

Rzaeva K.A.

Almazov National Medical Research Center

Manukyan S.N.

Meshalkin National Medical Research Center

Gorbatykh A.V.

Almazov National Medical Research Center

Zhuravleva I.Yu.

Meshalkin National Medical Research Center

Vladimirov S.V.

Meshalkin National Medical Research Center

Soynov I.A.

Meshalkin National Medical Research Center

Received:

12.07.2024

Accepted:

18.09.2024

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References:

  1. Bonhoeffer P, Boudjemline Y, Zakhia S, et al. Transcatheter implantation of a bovine valve in pulmonary position: a lamb study. Circulation. 2000:102:813-816.  https://doi.org/10.1161/01.cir.102.7.813
  2. Nordmeyer J, Khambadkone S, Coats L, et al. Risk stratification, systematic classification, and anticipatory management strategies for stent fr acture after percutaneous pulmonary valve implantation. Circulation. 2007;115:1392-1397. https://doi.org/10.1161/CIRCULATIONAHA.106.674259
  3. Manukyan SN, Soynov IA, Voitov AV, Rzaeva KA, Baranov AA, Bogachev-Prokofiev AV. Modern possibilities for transcatheter pulmonary valve replacement. Pirogov Russian Journal of Surgery. 2024;2:32-44. (In Russ.). https://doi.org/10.17116/hirurgia202402132
  4. Eicken A, Ewert P, Hager A, et al. Percutaneous pulmonary valve implantation: two-centre experience with more than 100 patients. Eur Heart J. 2011;27;32(10):1260-1265. https://doi.org/10.1093/eurheartj/ehq520
  5. Husain J, Praichasilchai P, Gilbert Y, et al. Early European experience with the Venus P-valve: filling the gap in percutaneous pulmonary valve implantation. Euro Intervention. 2016;12(5):e643-651.  https://doi.org/10.4244/EIJV12I5A105
  6. Benson L, Gillespie M, Bergersen L, et al. Three-Year Outcomes From the Harmony Native Outflow Tract Early Feasibility Study. Circ Cardiovasc Interv. 2020;13(1):e008320. https://doi.org/10.1161/CIRCINTERVENTIONS.119.008320
  7. Shang X, Chen S, Zhang C, et al. First-in-man implantation of Med-Zenith PT-Valve in right ventricular outflow tract for pulmonary regurgitation. JACC Cardiovasc Interv. 2019;12(19):1989-1990. https://doi.org/10.1016/j.jcin.2019.07.036
  8. Kim G, Song M, Bae E, et al. Successful feasibility human trial of a new self-expandable percutaneous pulmonary valve (Pulsta Valve) implantation using knitted nitinol wire backbone and trileaflet α-gal-free porcine pericardial valve in the native right ventricular outflow tract. Circ Cardiovasc Interv. 2018;11(6):e006494. https://doi.org/10.1161/circinterventions.118.006494
  9. Park WY, Kim GB, Lee SY, Kim AY, Choi JY, Jang SI, Kim SH, Cha SG, Wang JK, Lin MT, Chen CA. The adaptability of the Pulsta valve to the diverse main pulmonary artery shape of native right ventricular outflow tract disease. Catheter Cardiovasc Interv. 2024;103(4): 587-596.  https://doi.org/10.1002/ccd.30968
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