Necrotizing infection of the skin and soft tissues is a disease that is often accompanied by severe sepsis and septic shock. The fulminant nature of the course, complex differential diagnosis in the early stages of the disease determines the high mortality rate in patients with necrotizing infections. The presented clinical case provides an example of successful treatment of this pathology in a patient with severe comorbidity, in the complex treatment of which local negative pressure therapy was used at an early stage, before the end of the necrobiotic phase, during the course of the infectious process. Further management and preparation of the wound for closure was carried out using an installation type NPWT system.