OBJECTIVE

To compare the efficacy of regional catheter thrombolysis with urokinase and alteplase for late proximal deep vein thrombosis.

MATERIAL AND METHODS

We analyzed safety and effectiveness of treatment of 38 patients with late proximal deep vein thrombosis divided into 2 statistically homogeneous groups by 19 people. In the first group, regional thrombolysis with urokinase was performed with injection of the drug into thrombosed popliteal, femoral and iliac veins. Alteplase was used in the second group. Patients received rivaroxaban in pre-, perioperative period and throughout 6 months after surgery. Complications of endovascular therapy were recorded. After 12 months, ultrasound and clinical examination were carried out to assess vein recanalization and venous outflow disorders. Vein recanalization was evaluated as follows: <50% — minimal, 50—99% — partial, 100% — complete.

RESULTS

Minor hemorrhagic complications of endovascular treatment developed in 31.7 and 21% of patients, respectively. In the first group, complete vein recanalization occurred in 31.6%, partial — in 21%, minimal — in 47.4% of patients. In the second group, these values were 47.4%, 36.8% and 15.8%, respectively. In the first group, no signs of venous outflow disorders were observed in 31.6% of patients, mild disorders — in 15.8%, moderate disorders — in 31.6%, severe — in 21% of patients. In the second group, these values were 47.4%, 31.6%, 10.5% and 10.5%, respectively.

CONCLUSION

Thrombolysis with alteplase is safer and more effective compared to urokinase.