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Esakov Yu.S.

Moscow City Oncology Hospital No. 1

Shrainer I.V.

Moscow City Oncology Hospital No. 1

Kirpichnikova E.I.

Moscow City Oncology Hospital No. 1

Kulikova E.A.

Moscow City Oncology Hospital No. 1

Efteev L.A.

Moscow City Oncology Hospital No. 1

Tukvadze Z.G.

Moscow City Oncology Hospital No. 1

Khvedelidze G.V.

Moscow City Oncology Hospital No. 1

Galkin V.N.

Moscow City Oncology Hospital No. 1

Clinical efficacy of ct-guided transthoracic needle biopsy of peripheral lung lesions

Authors:

Esakov Yu.S., Shrainer I.V., Kirpichnikova E.I., Kulikova E.A., Efteev L.A., Tukvadze Z.G., Khvedelidze G.V., Galkin V.N.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(5): 34‑42

DOI: 10.17116/hirurgia202205134

Read: 5267 times

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Table of contents

CLINICAL EFFICACY OF CT-GUIDED TRANSTHORACIC NEEDLE BIOPSY OF PERIPHERAL LUNG LESIONS
CLINICAL EFFICACY OF CT-GUIDED TRANSTHORACIC NEEDLE BIOPSY OF PERIPHERAL LUNG LESIONS

To cite this article:

Esakov YuS, Shrainer IV, Kirpichnikova EI, et al. . Clinical efficacy of ct-guided transthoracic needle biopsy of peripheral lung lesions. Pirogov Russian Journal of Surgery. 2022;(5):34‑42. (In Russ.)
https://doi.org/10.17116/hirurgia202205134

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the effectiveness of a step-by-step protocol for GT-guided transthoracic biopsy in verification of peripheral lung tumors.

MATERIAL AND METHODS

A retrospective analysis of the results of GT-guided transthoracic biopsies of focal lung neoplasms was performed between October 2019 and December 2020. The analysis included the results of 176 biopsies in 158 patients.

RESULTS

Primary biopsy was informative in 139 (87.97%) out of 158 patients. There were 155 (88.07%) informative and 21 (11.93%) non-informative biopsies. Lung adenocarcinoma was diagnosed in 41 (25.95%) patients, squamous cell carcinoma in 35 (22.15%) patients, and small cell carcinoma in 9 (5.7%) patients. There were 17 (10.76%) patients with uninformative biopsy results. Sensitivity, specificity and accuracy were 86%, 95.5%, and 87.8%, respectively. PPV was 98.9%, NPV — 58.3%. Various complications occurred after 65 (36.93%) out of 176 biopsies (95% CI 30.15—44.27). Pneumothorax followed by pleural drainage was detected after 8 (4.55%) biopsies.

CONCLUSION

Accuracy of a step-by-step protocol for transthoracic biopsy was 88% that is not inferior to similar results in large-scale studies devoted to specialized navigation systems.

Keywords:

transthoracic lung biopsy
MSCT
NSCLC
peripheral lung cancer

Authors:

Esakov Yu.S.

Moscow City Oncology Hospital No. 1

Shrainer I.V.

Moscow City Oncology Hospital No. 1

Kirpichnikova E.I.

Moscow City Oncology Hospital No. 1

Kulikova E.A.

Moscow City Oncology Hospital No. 1

Efteev L.A.

Moscow City Oncology Hospital No. 1

Tukvadze Z.G.

Moscow City Oncology Hospital No. 1

Khvedelidze G.V.

Moscow City Oncology Hospital No. 1

Galkin V.N.

Moscow City Oncology Hospital No. 1

Received:

25.08.2021

Accepted:

18.10.2021

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References:

  1. Geeroms B, Cockmartin L, Coolen J, Dubbeldam A, Verschakelen J, Nikoghosyan A, Wever WD. CT-Guided Transthoracic Biopsy of Lung Lesions Using a Non-Coaxial Biopsy Needle Technique: CT Characteristics Predictive for Diagnostic Accuracy and Pneumothorax. Journal of the Belgian Society of Radiology. 2021;105(1):39:1-9.  https://doi.org/10.5334/jbsr.2429
  2. Shechter YI, Yudin AL. Results of diagnostic and therapeutic punctures of a number of internal organs under the control of computed tomography. Journal of Radiology and nuclear medicine. 1990;56:20. (In Russ.).
  3. Zhu J, Wang X, Qu Y, Wen Z. CT-guided core needle biopsy of the lung in patients with primary malignancy suspected of lung metastasis: 5-year experience from a single institution. Diagn Interv Radiol. 2021; 27:534-541.  https://doi.org/10.5152/dir.2021.20042
  4. Arseniev AI, Barchuk AA, Kostitsin KA, Nefedova AV, Barchuk AS, Chernaja AV, Levchenko EV, Tarkov SA, Nefedov AO, Gagua KE. Panel study of the effectiveness of low-dose computed tomography and transthoracic core biopsy in early diagnostics of lung cancer. Grekov’s Bulletin of Surgery. 2018;177(1):60-64. (In Russ.). https://doi.org/10.24884/0042-4625-2018-177-1-60-64
  5. Merabishvili VM, Arseniev AI, Tarkov SA, Barchuk AA, Shcherbakov AM, Demin EV, Merabishvili EN. Lung cancer morbidity and mortality. Siberian journal of oncology. 2018;17(6):15-26. (In Russ.). https://doi.org/10.21294/1814-4861-2018-17-6-15-26
  6. Knight SB, Crosbie PA, Balata H, et al. Progress and prospects of early detection in lung cancer [Electronic resource]. Open Biology. 2017;7(9):e170070. https://royalsocietypublishing.org/doi/full/10.1098/rsob.17007
  7. Shlomi D, Ben-Avi R, Balmor GR, Onn A, Peled N. Screening for lung cancer: time for large-scale screening by chest computed tomography. Eur Respir J. 2014;44(1):217-238.  https://doi.org/10.1183/09031936.00164513
  8. de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, Lammers JJ, Weenink C, Yousaf-Khan U, Horeweg N, van ‘t Westeinde S, Prokop M, Mali WP, Mohamed Hoesein FAA, van Ooijen PMA, Aerts JGJV, den Bakker MA, Thunnissen E, Verschakelen J, Vliegenthart R, Walter JE, Ten Haaf K, Groen HJM, Oudkerk M. Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial. N Engl J Med. 2020;382(6): 503-513.  https://doi.org/10.1056/NEJMoa1911793
  9. Gombolevskiy V.A, Nikolaev AE, Shapiev AN, et al. Morozov Management of Patients with Solid Pulmonary Nodules Detected in Lung Cancer Screening. Novosti Khirurgii. 2019;27(5):553-562. (In Russ.).
  10. Gombolevsky VA, Barchuk AA, Laipan AS, Vetsheva NN, Vladzymyrskyy AV, Morozov SP. Lung Cancer Screening with Low-Dose Computed Tomography: Management and Efficiency. Radiology — Practice. 2018;(1):28-36. (In Russ.).
  11. Deweerdt S. Aetiology: Crucial clues. Nature. 2014;513(7517):12-13.  https://doi.org/10.1038/513S12a
  12. Li Y, Wang T, Fu YF, Shi YB, Wang JY. Computed tomography-guided biopsy for sub-centimetre lung nodules: Technical success and diagnostic accuracy. Clin Respir J. 2020;14(7):605-610.  https://doi.org/10.1111/crj.13172
  13. Lee KH, Lim KY, Suh YJ, Hur J, Han DH, Kang MJ, Choo JY, Kim C, Kim JI, Yoon SH, Lee W, Park CM. Nondiagnostic Percutaneous Transthoracic Needle Biopsy of Lung Lesions: A Multicenter Study of Malignancy Risk. Radiology. 2019;290(3):814-823.  https://doi.org/10.1148/radiol.2018181482
  14. Andrade JR, Rocha RD, Falsarella PM, Rahal Junior A, Santos RSD, Franceschini JP, Fernando HC, Garcia RG. CT-guided percutaneous core needle biopsy of pulmonary nodules smaller than 2 cm: technical aspects and factors influencing accuracy. J Bras Pneumol. 2018;44(4):307-314.  https://doi.org/10.1590/S1806-37562017000000259
  15. Fontaine-Delaruelle C, Souquet PJ, Gamondes D, Pradat E, De Leusse A, Ferretti GR, Couraud S. Negative Predictive Value of Transthoracic Core-Needle Biopsy: A Multicenter Study. Chest. 2015;148(2):472-480. PMID: 25569025. https://doi.org/10.1378/chest.14-1907
  16. Welborn SL, Ohori NP, Nason KS, Pennathur A, Awais O, Christie NA, Luketich JD, Schuchert MJ. Percutaneous computed tomography-guided biopsy performed by thoracic surgeons in 955 patients: A paradigm shift in image-guided thoracic procedures. J Thorac Cardiovasc Surg. 2019;157(3):1239-1245. https://doi.org/10.1016/j.jtcvs.2018.09.125
  17. Haas BM, Elicker BM, Nguyen J, Ordovas KG, Jones KD, Henry TS, Naeger DM. Nondiagnostic Computed Tomography-guided Percutaneous Lung Biopsies Are More Likely When Infection Is Suspected. J Thorac Imaging. 2016;31(3):151-155.  https://doi.org/10.1097/RTI.0000000000000207
  18. Mills M, Choi J, El-Haddad G, Sweeney J, Biebel B, Robinson L, Antonia S, Kumar A, Kis B. Retrospective analysis of technical success rate and procedure-related complications of 867 percutaneous CT-guided needle biopsies of lung lesions. Clin Radiol. 2017;72(12):1038-1046. https://doi.org/10.1016/j.crad.2017.07.023
  19. Tongbai T, McDermott S, Kiranantawat N, Muse VV, Wu CCC, Shepard JAO, Gilman MD. Non-Diagnostic CT-Guided Percutaneous Needle Biopsy of the Lung: Predictive Factors and Final Diagnoses. Korean J Radiol. 2019;20(11):1515-1526. https://doi.org/10.3348/kjr.2019.0014
  20. Chae KJ, Hong H, Yoon SH, et al. Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy: A Meta-analysis. Sci Rep. 2019;9:12428. https://doi.org/10.1038/s41598-019-48805-x
  21. Portela de Oliveira E, Souza CA, Inacio JR, Abdelzarek M, Dennie C, Gupta A, Bayanati H. Imaging-guided Percutaneous Biopsy of Nodules ≤1 cm: Study of Diagnostic Performance and Risk Factors Associated With Biopsy Failure. J Thorac Imaging. 2020;35(2):123-128.  https://doi.org/10.1097/RTI.0000000000000427
  22. Huang MD, Weng HH, Hsu SL, et al. Accuracy and complications of CT-guided pulmonary core biopsy in small nodules: a single-center experience. Cancer Imaging. 2019;19:51.  https://doi.org/10.1186/s40644-019-0240-6
  23. Chang YY, Chen CK, Yeh YC, Wu MH. Diagnostic feasibility and safety of CT-guided core biopsy for lung nodules less than or equal to 8 mm: A single-institution experience. Eur Radiol. 2018;28(2):796-806.  https://doi.org/10.1007/s00330-017-5027-1
  24. Takeshita J, Masago K, Kato R, Hata A, Kaji R, Fujita S, Katakami N. CT-guided fine-needle aspiration and core needle biopsies of pulmonary lesions: a single-center experience with 750 biopsies in Japan. AJR Am J Roentgenol. 2015;204(1):29-34.  https://doi.org/10.2214/AJR.14.13151
  25. Fu YF, Li GC, Xu QS, Shi YB, Wang C, Wang T. Computed tomography-guided lung biopsy: a randomized controlled trial of low-dose versus standard-dose protocol. Eur Radiol. 2020;30(3):1584-1592. https://doi.org/10.1007/s00330-019-06464-6
  26. Kiranantawat N, Petranović M, McDermott S, Gilman M, Digumarthy SR, Shepard JO, Sharma A. Feasibility and accuracy of CT-guided percutaneous needle biopsy of cavitary pulmonary lesions. Diagn Interv Radiol. 2019;25(6):435-441.  https://doi.org/10.5152/dir.2019.18061
  27. Nath A, Neyaz Z, Hashim Z, Agrawal V, Richa M. Role of Percutaneous Computed Tomography-guided Lung Biopsy in Non-resolving Consolidation and Identification of Clinical and High-resolution Computed Tomography Characteristics Predicting Outcome. J Clin Imaging Sci. 2019;9:48.  https://doi.org/10.25259/JCIS_126_2019
  28. Otto S, Mensel B, Friedrich N, Schäfer S, Mahlke C, von Bernstorff W, Bock K, Hosten N, Kühn JP. Predictors of technical success and rate of complications of image-guided percutaneous transthoracic lung needle biopsy of pulmonary tumors. PLoS One. 2015;10(4):e0124947.
  29. Kothary N, Lock L, Sze DY, Hofmann LV. Computed tomography-guided percutaneous needle biopsy of pulmonary nodules: impact of nodule size on diagnostic accuracy. Clin Lung Cancer. 2009;10(5): 360-363.  https://doi.org/10.3816/CLC.2009.n.049
  30. Kachur AK, Shrainer IV, Lyadov VK. Experience of 100 transthoracic needle biopsies of the lung under CT navigation. Voprosy oncologii. 2016;5:676-679. (In Russ.).
  31. DiBardino DM, Yarmus LB, Semaan RW. Transthoracic needle biopsy of the lung. J Thorac Dis. 2015;7(4):304-316.  https://doi.org/10.3978/j.issn.2072-1439.2015.12.16
  32. Heerink WJ, de Bock GH, de Jonge GJ, et al. Complication rates of CT-guided transthoracic lung biopsy: meta-analysis. Eur Radiol. 201;27: 138-148.  https://doi.org/10.1007/s00330-016-4357-8
  33. Lee KH, Lim KY, Suh YJ, Hur J, Han DH, Kang MJ, Choo JY, Kim C, Kim JI, Yoon SH, Lee W, Park CM. Diagnostic Accuracy of Percutaneous Transthoracic Needle Lung Biopsies: A Multicenter Study. Korean J Radiol. 2019;20(8):1300-1310. https://doi.org/10.3348/kjr.2019.0189
  34. Priola AM, Priola SM, Cataldi A, Errico L, Di Franco M, Campisi P, Molinaro L, Marci V, Novello S, Fava C. Accuracy of CT-guided transthoracic needle biopsy of lung lesions: factors affecting diagnostic yield. Radiol Med. 2007;112(8):1142-1159. (English, Italian). https://doi.org/10.1007/s11547-007-0212-y
  35. Vagn-Hansen C, Pedersen MR, Rafaelsen SR. Diagnostic yield and complications of transthoracic computed tomography-guided biopsies. Dan Med J. 2016;63(6):A5239.
  36. O’Neill AC, McCarthy C, Ridge CA, Mitchell P, Hanrahan E, Butler M, Keane MP, Dodd JD. Rapid needle-out patient-rollover time after percutaneous CT-guided transthoracic biopsy of lung nodules: effect on pneumothorax rate. Radiology. 2012;262(1):314-319.  https://doi.org/10.1148/radiol.11103506
  37. Yoon SH, Park CM, Lee KH, Lim KY, Suh YJ, Im DJ, Hur J, Han DH, Kang MJ, Choo JY, Kim C, Kim JI, Hong H. Analysis of Complications of Percutaneous Transthoracic Needle Biopsy Using CT-Guidance Modalities In a Multicenter Cohort of 10568 Biopsies. Korean J Radiol. 2019;20(2):323-331.  https://doi.org/10.3348/kjr.2018.0064
  38. Anzidei M, Porfiri A, Andrani F, et al. Imaging-guided chest biopsies: techniques and clinical results. Insights Imaging. 2017;8:419-428.  https://doi.org/10.1007/s13244-017-0561-6
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