The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
Phones:
+7 (495) 482-4118
+7 (495) 482-4329
  • Toll-free number for subscriptions:
    +8 800 250-18-12
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Topolnitskiy E.B.

Siberian State Medical University;
Tomsk Regional Clinical Hospital;
Tomsk State University

Shefer N.A.

Siberian State Medical University;
Tomsk Regional Clinical Hospital

Marchenko E.S.

Tomsk State National Research University

Chekalkin T.L.

Tomsk State National Research University

Khakimov Kh.I.

Research Institute of Oncology of the Tomsk National Research Medical Center

Reconstruction of post-resection chest wall defects in surgical treatment of invasive non-small cell lung cancer

Authors:

Topolnitskiy E.B., Shefer N.A., Marchenko E.S., Chekalkin T.L., Khakimov Kh.I.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2022;(12): 31‑40

DOI: 10.17116/hirurgia202212131

Read: 2224 times

Contact the author
Table of contents

RECONSTRUCTION OF POST-RESECTION CHEST WALL DEFECTS IN SURGICAL TREATMENT OF INVASIVE NON-SMALL CELL LUNG CANCER
RECONSTRUCTION OF POST-RESECTION CHEST WALL DEFECTS IN SURGICAL TREATMENT OF INVASIVE NON-SMALL CELL LUNG CANCER

To cite this article:

Topolnitskiy EB, Shefer NA, Marchenko ES, Chekalkin TL, Khakimov KhI. Reconstruction of post-resection chest wall defects in surgical treatment of invasive non-small cell lung cancer. Pirogov Russian Journal of Surgery. 2022;(12):31‑40. (In Russ.)
https://doi.org/10.17116/hirurgia202212131

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Prediction of respiratory complications after exte­nsive chest wall rese­ctions. Piro­gov Russian Journal of Surgery. 2025;(12):14-22
Abstract:

OBJECTIVE

To present the results of reconstruction of post-resection chest wall defects with nickel-titanium (TiNi) implants in patients with invasive NSCLC and to analyze the features of perioperative management.

MATERIAL AND METHODS

We enrolled 9 patients with NSCLC involving the ribs after lobectomy or pneumonectomy with chest wall reconstruction. Defects were closed used TiNi mesh and rib prostheses. We selected the shape and dimensions of artificial ribs individually before surgery according to CT data and 3D models of reinforcing elements.

RESULTS

There were male smokers aged 64.6±4.6 years among patients (range 58-73). T3N0M0 was diagnosed in 6 patients, T3N1M0 — 2, T3N2M0 — 1. Squamous cell carcinoma was verified in 4 (44.4%) patients, adenocarcinoma — in 5 (55.6%) patients. All patients had comorbidities. Mean Charlson’s comorbidity index was 6.56±4.6. Dimension of chest wall defect varied from 78 to 100 cm2. Postoperative period was uneventful without signs of respiratory failure. There were no lethal outcomes. Complications occurred in 33.3% of patients (prolonged air discharge through the drains, pleuritis and atrial fibrillation).

CONCLUSION

Surgical treatment of NSCLC spreading to the chest wall is a complex task requiring further improvement. Bioadaptive TiNi implants are a promising reinforcing material that allows successful reconstruction of post-resection chest wall defects with good anatomical, functional and cosmetic results. «Sandwich» technology is advisable for extensive defects. This approach includes 2 layers of knitted mesh and rib prostheses between these layers.

Keywords:

locally advanced lung cancer
chest wall reconstruction
extensive defect closure
rib prostheses
nickel-titanium implant

Authors:

Topolnitskiy E.B.

Siberian State Medical University;
Tomsk Regional Clinical Hospital;
Tomsk State University

Shefer N.A.

Siberian State Medical University;
Tomsk Regional Clinical Hospital

Marchenko E.S.

Tomsk State National Research University

Chekalkin T.L.

Tomsk State National Research University

Khakimov Kh.I.

Research Institute of Oncology of the Tomsk National Research Medical Center

Received:

15.05.2022

Accepted:

15.07.2022

Close metadata

References:

  1. Elia S, Griffo S, Gentile M, Costabile R, Ferrante G. Surgical treatment of lung cancer invading chest wall: a retrospective analysis of 110 patients. Eur J Cardiothorac Surg. 2001;20(2):356-360.  https://doi.org/10.1016/s1010-7940(01)00735-7
  2. Kumar N, Malik PS, Bharati SJ, Yadav M, Jain D, Kumar S. Primary lung cancer with chest wall involvement: Outcomes of a multimodality management approach. Lung India. 2021;38(4):338-342.  https://doi.org/10.4103/lungindia.lungindia_725_20
  3. Filosso PL, Sandri A, Guerrera F, Solidoro P, Bora G, Lyberis P, Ruffini E, Oliaro A. Primary lung tumors invading the chest wall. J Thorac Dis. 2016;8(11):855-862.  https://doi.org/10.21037/jtd.2016.05.51
  4. Pikin OV, Trakhtenberg AKh, Ryabov AB, Glushko BA, Kolbanov KI, Barmin VV, Amiraliev AM, Vursol DA. Results of surgical treatment in patients with non-small cell lung cancer with tumor ingrowth into the chest. Onkologiya. Zurnal im. P.A. Gertsena. 2016;3:39-43. (In Russ.). https://doi.org/10.17116/onkolog20165339-43
  5. Facciolo F, Cardillo G, Lopergolo M, Pallone G, Sera F, Martelli M. Chest wall invasion in non-small cell lung carcinoma: a rationale for en bloc resection. J Thorac Cardiovasc Surg. 2001;121(4):649-656.  https://doi.org/10.1067/mtc.2001.112826
  6. Carvajal C, Ramirez AM, Guerrero-Macías S, Beltrán R, Buitrago R, Carreño J. A South American experience with postoperative complications following chest wall reconstruction for neoplasms. World J Surg. 2021;45(10):2982-2992. https://doi.org/10.1007/s00268-021-06215-z
  7. Scarnecchia E, Liparulo V, Capozzi R, Ceccarelli S, Puma F, Vannucci J. Chest wall resection and reconstruction for tumors: analysis of oncological and functional outcome. J Thorac Dis. 2018;10(16):1855-1863. https://doi.org/10.21037/jtd.2018.05.191
  8. Miller DL, Force SD, Pickens A, Fernandez FG, Luu T, Mansour KA. Chest wall reconstruction using biomaterials. Ann Thorac Surg. 2013;95(3):1050-1056. https://doi.org/10.1016/j.athoracsur.2012.11.024
  9. Vishnevskii AA, Rudakov SS, Milanov NO. Khirurgiya grudnoi stenki. M.: Vidar; 2005. (In Russ.).
  10. Loi M, Mazzella A, Desideri I, Fournel L, Hamelin EC, Icard P, Bobbio A, Alifano M. Chest wall resection and reconstruction for lung cancer: surgical techniques and example of integrated multimodality approach. J Thorac Dis. 2020;12(1):22-30.  https://doi.org/10.21037/jtd.2019.07.81
  11. Wang L, Yan X, Zhao J, et al. Expert consensus on resection of chest wall tumors and chest wall reconstruction. Transl Lung Cancer Res. 2021;10(11):4057-4083. https://doi.org/10.21037/tlcr-21-935
  12. Seder CW, Rocco G. Chest wall reconstruction after extended resection. J Thorac Dis. 2016;8(suppl 11):863-871.  https://doi.org/10.21037/jtd.2016.11.07
  13. Sanna S, Brandolini J, Pardolesi A, Argnani D, Mengozzi M, Dell’Amore A, Solli P. Materials and techniques in chest wall reconstruction: a review. J Vis Surg. 2017;3:95.  https://doi.org/10.21037/jovs.2017.06.10
  14. Sandri A, Donati G, Blanc CD, Nigra VA, Gagliasso M, Barmasse R. Anterior chest wall resection and sternal body wedge for primary chest wall tumor: reconstruction technique with biological meshes and titanium plates. J Thorac Dis. 2020;12(1):17-21.  https://doi.org/10.21037/jtd.2019.06.45
  15. Sobolevskiy VA, Dikov YY. First experience of using Stratos reconstructive system and Gore-Tex Dual-Mesh for the subtotal sternum defect reconstruction. Carkomy kostey, myagkikh tkaney i opukholi kozhi. 2013;1:81-84. (In Russ.).
  16. Larin IA, Tarasov VA, Khubulava GG, Gavrilov EK. Vozmozhnosti operativnogo lecheniya bol’nykh s obshirnymi zlokachestvennymi porazheniyami grudnoi stenki. Klinicheskaya meditsina. 2015;7:40-45. (In Russ.).
  17. Sobolevskiy VA, Dikov YY, Mezhetskiy EP. First experience of using Stratos reconstructive system and Gore-Tex Dual-Mesh for the subtotal sternum defect reconstruction. Bone and soft tissue sarcomas, tumors of the skin. 2016;3:7-10. (In Russ.).
  18. Wen X, Gao S, Feng J, Li S, Gao R, Zhang G. Chest-wall reconstruction with a customized titanium-alloy prosthesis fabricated by 3D printing and rapid prototyping. J Cardiothoracic Surg. 2018;13(4). https://doi.org/10.1186/s13019-017-0692-3
  19. Wu Y, Chen N, Xu Z, Zhang X, Liu L, Wu C, Zhang S, Song Y, Wu T, Liu H, Tang M, Wu W. Application of 3D printing technology to thoracic wall tumor resection and thoracic wall reconstruction. J Thorac Dis. 2018;10(12):6880-6890. https://doi.org/10.21037/jtd.2018.11.109
  20. Kurilchik AA, Usachev VS, Ivanov VE, Starodubtsev AL, Zubarev AL. Forms of sternal reconstruction in oncology. Grekov’s Bulletin of Surgery. 2021;180(2):57-62. (In Russ.). https://doi.org/10.24884/0042-4625-2021-180-2-57-62
  21. Salkov AG, Valiev AK, Kharatishvili TK, Sushentsov EA, Petrochenko NS, Badyrov RN, Agaev DK, Mezhetsky EP. First experience of successful total extription of sternum with replacement of the defect by an individual 3D-implant and synthetic plate. clinical case. Bone and soft tissue sarcomas, tumors of the skin. 2020;12(1):62-67. (In Russ.).
  22. Zheravin AA, Gyunter VE, Anisenya II, Garbukov EYu, Zhamgaryan GS, Bogoutdinova AV. Reconstruction of the chest wall using titaniun nickelid for cancer patients. Siberian Journal of Oncology. 2015;3:31-38. (In Russ.).
  23. Topolnitskiy EB, Shefer NA, Marchenko ES, Chekalkin TL, Yasenchuk YF. Chest wall resection for neoplasms with reconstruction using titanium-nickelide implants. P.A. Herzen Journal of Oncology. 2021;10(2):22-28. (In Russ.). https://doi.org/10.17116/onkolog20211002122
  24. Topolnitskiy E, Chekalkin T, Marchenko E, Yasenchuk Y. Repair of huge thoracic defect combined with hernia after multimodality treatment of breast cancer. Respir Med Case Rep. 2021;23;34:101558. https://doi.org/10.1016/j.rmcr.2021.101558
  25. Topolnitskiy E, Chekalkin T, Marchenko E, Yasenchuk Y, Kang SB, Kang JH, Obrosov A. Evaluation of Clinical Performance of TiNi-Based Implants Used in Chest Wall Repair after Resection for Malignant Tumors. J Funct Biomater. 2021;12(4):60.  https://doi.org/10.3390/jfb12040060
  26. Yasenchuk Y, Marchenko E, Baigonakova G, Gunther S, Kokorev O, Gunter V, Chekalkin T, Topolnitskiy E, Obrosov A, Kang JH. Study on tensile, bending, fatigue, and in vivo behavior of porous SHS-TiNi alloy used as a bone substitute. Biomed Mater. 2021;16(2):021001. https://doi.org/10.1088/1748-605X/aba327
  27. Topolnitsky EB, Dambayev GT, Gyunther VE, Baikov AN, Khodorenko VN, Fomina TI, Shefer NA. Morphological assessment of method of postresection pericardial defect closure using fabric implant on basis of nanostructural nikelide titanium fiber. Bulletin of Siberian Medicine. 2011;10(3):62-66. (In Russ.). https://doi.org/10.20538/1682-0363-2011-3-62-66
  28. Pikin OV, Ryabov AB, Trakhtenberg AKh, Glushko VA, Kolbanov KI. Amiraliev AM. Analysis of postoperative complications according to the TMM system in patients with non-small cell lung cancer after pneumonectomy over a 5-year period. Khirurgiya. Zhurnal im. N.I. Pirogova. 2016;1-2:23-27. (In Russ.). https://doi.org/10.17116/hirurgia20161223-27
  29. Teplyakov VV, Karpenko VYu, Ilyushin AL, Donskova YuS, Sobchenko AA, Dolgova SG, Epifanova SV, Derzhavin VA, Bukharov AV, Bondarev AV. Surgical treatment of malignant tumors of the chest wall. Khirurgiya. Zurnal im. N.I. Pirogova. 2010;9:36-41. (In Russ.).
  30. Topolnitsky EB, Gunter VE, Dambaev GTs, Efteev LA, Proskurin AV, Zheravin AA. A method of covering extensive fenestrated thoracoabdominal defects. Patent for invention RU 2600849 C1, 10/27/2016. Application No. 201522940/14 dated 06/15/15. (In Russ.).
  31. Kaprin AD, Starinsky VV, Shakhzadova AO. The state of oncological care for the population of Russia in 2020. M.: MNIOI im. P.A. Herzen — branch of the Federal State Budgetary Institution «NMITs Radiology» of the Ministry of Health of Russia; 2021;239. (In Russ).
  32. Topolnitsky EB, Borodina YuA. Immediate results of surgical treatment of non-small cell lung cancer in elderly and senile patients. Khirurgiya. Zhurnal im. N.I. Pirogova. 2020;10:23-28. (In Russ.). https://doi.org/10.17116/hirurgia202010123
  33. Akay H, Cangir AK, Kutlay H, Kavukçu S, Okten I, Yavuzer S. Surgical treatment of peripheral lung cancer adherent to the parietal pleura. Eur J Cardiothorac Surg. 2002;22(4):615-620.  https://doi.org/10.1016/s1010-7940(02)00408-6
  34. Spicer JD, Shewale JB, Antonoff MB, Correa AM, Hofstetter WB, Rice DC, Vaporciyan AA, Mehran RJ, Walsh GL, Roth JA, Swisher SG, Sepesi B. The influence of reconstructive technique on perioperative pulmonary and infectious outcomes following chest wall resection. Ann Thorac Surg. 2016;102(5):1653-1659. https://doi.org/10.1016/j.athoracsur.2016.05.072
  35. Stoelben E, Ludwig C. Chest wall resection for lung cancer: indications and techniques. Eur J Cardiothorac Surg. 2009;35(3):450-456.  https://doi.org/10.1016/j.ejcts.2008.11.032
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.