Ischemia-reperfusion syndrome

Neymark M.I.

doi:https://doi.org/10.17116/hirurgia202109171

Close metadata

Recommended articles:

Possibilities of 3D modeling for determining treatment approach for minor bile duct injuries. Pirogov Russian Journal of Surgery. 2025;(11):79-85

Metabolic correction of systemic oxidative-toxic lesions in urgent abdominal surgery. Pirogov Russian Journal of Surgery. 2026;(3):63-70

Effect of perioperative fluid therapy on ischemia-reperfusion syndrome in elective percutaneous coronary interventions. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(5):586-592

Analytical review of the pathophysiological mechanisms of ischemia-reperfusion syndrome development in PCI. Russian Journal of Anesthesiology and Reanimatology. 2025;(5):88-97

Abstract:

The ischemia-reperfusion syndrome complicates the course of a number of emergency conditions in various fields of clinical medicine, determines the course, prognosis and outcome of the disease. This review examines various aspects of the etiology, pathogenesis, and clinical manifestations of this syndrome. Particular attention is paid to its prevention and treatment. It is indicated that most of the studies devoted to this problem are of an experimental nature. The use of preparations based on succinic acid in the clinic is seen as the most promising direction in solving this issue.

Keywords:

ischemia-reperfusion syndrome

succinate solutions

peamberin

Authors:

Neymark M.I.

Altai State Medical University

ORCID: 0000-0001-9135-6392

Received:

28.05.2021

Accepted:

16.06.2021

Close metadata

References:

Kutepov DI, ZHigalova MS, Pasechnik IN. Pathogenesis of ischemia-reperfusion syndrome. Kazanskij meditsinskij zhurnal. 2018;99(4):640-644. (In Russ.). https://doi.org/10.17816/KMJ2018-640
Blaisdell FW. The pathophysiology of skeletal muscle ischemia and reperfusion syndrome: a review. Cardiovasc Surg. 2002;10(6):620-630. https://doi.org/10.1016/s0967-2109(02)00070-4
Bertoni S, Ballabeni V, Barocelli E. Tognolini M. Mesenteric ischemia-reperfusion: an overview of preclinical drug strategies. Drug Discov Today. 2018;23(7):1416-1425. https://doi.org/10.1016/j.drudis.2018.05.034
Koksal GM. Oxidative stress and its complication in human health. Advances in Bioscience and Biotechnology. 2012;03(08):1113-1115. https://doi.org/10.4236/abb.2012.38136
Kolyadko AV, Lang EA, Govorova NV, Bojko TV, Orlov YuP. Reperfusion paradoxes in the practice of critical conditions: the possibility of solving. Vestnik SurGU. Meditsina. 2020;45(3):69-75. (In Russ.). https://doi.org/10.34822/2304-9448-2020-3-69-75
Vishal Kumar Vishwakarma, Prabhat Kumar Upadhyay, Jeetendra Kumar Gupta, Harlokesh Narayan Yadav Pathophysiologic role of ischemia reperfusion injury: A review. Journal of Indian College of Cardiology. 2017;7(3):97-104. https://doi.org/10.1016/j.jicc.2017.06.017
Billah M, Ridiandres A, Allahwala U, Mudaliar H, Dona A, Hunyor S, Khachigian LM, Bhindi R. Circulating Mediators of Remote ischemic Preconditioning: Search for the Missisg Link Between Non-Lethal ischemia and Cardioprotection. Onkotarget. 2019;2(10):216-244. https://doi.org/10.18632/oncotarget.26537
Francis A. Baynosa R. Ischemia-reperfusion injury and hyperbaric oxygen pathways: a review of cellular mechanisms. Diving Hyperb Med. 2017;47(2):110-117. https://doi.org/10.28920/dhm47.2.110-117
Spoelstra-de Man AEM, Elbers PWG, Oudermans-van Straaten HM. Making Sense of Early High-dose Intravenous Vitamin C in Ischemia/Reperfusion Injery. Crit Care. 2018;20;22(1):70. https://doi.org/10.1186/s13054-018-1996-y
Meng-Yu Wu, Giou-Teng Yang, Wan-Ting Liao et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cellular Physiology and Biochemistry. Cell Physiol Biochem. 2018;46(4):1650-1667. https://doi.org/10.1159/000489241
Hilbert T, Klaschik S. The angiopoietin/TIE receptor system: Focusing its role forischemia-reperfusion injury. Cytokine Growth Factor Rev. 2015;26(3):281-291. https://doi.org/10.1016/j.cytogfr.2014.10.013
Nebylitsin YuS, Lazuko SS, Kut’ko E. A Lower limb ischemia-reperfusion syndrome. Vestnik VGMU. 2018;6:18-31. (In Russ.). https://doi.org/10.22263/2312-4156.2018.6.18
Cannistra M, Ruggiero M, Zullo F, et al. Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers. Int J Surg. 2016;33(1S):57-70. Epub 2016 May 30. https://doi.org/10.1016/j.ijsu.2016.05.050
Robins M, Wyatt HA. Hyperbaric Treatment of Ischemia Reperfusion Injury. StatPearls. 2020 February 18. https://www.ncbi.nlm.nih.gov/books/NBK513221/
Spoelstra-de Man AME, Elbers PWG, Oudemans-van Straaten HM. Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. Crit Care. 2018;22(1):70. https://doi.org/10.1186/s13054-018-1996-y
Oliva J. Therapeutic Properties of Mesenchymal Stem Cell on Organ Ischemia-Reperfusion Injury. Int J Mol Sci. 2019;20(21):5511. https://doi.org/10.3390/ijms20215511
Becker F, Robert-Ebady H, Ricco JB, et al. Charter I. Definitions, epidemiology, clinical prasintation and prognosis. Eur J Vasc Endovasc Surg. 2011;42(2):4-12. https://doi.org/10.1016/S1078-5884(11)60009-9
https://angiologia.ru/journal_angiologia/angiology/0007/
Choi JH, Pile-Spellman J. Reperfusion Changes After Stroke and Practical Approaches for Neuroprotection. Neuroimag Clin N Am. 2018;28:663-682. https://doi.org/10.1016/j.nic.2018.06.008
Patel RAG, McMullen PW. Neuroprotection in the Treatment of Acute Ischemic Stroke. Science Direct. Prog Cardiovasc Dis. 2017;59(6):542-548. https://doi.org/10.1016/j.pcad.2017.04.005
Pas’ko VG, Ardashev VN, Titarova YuYu, Tikhonravov AV. Oxidative stress in reperfusion syndrome and methods for its correction. Kremlevskaya meditsina. Klinicheskij vestnik. 2018;1:150-153. (In Russ.).
Soares ROS, Losada DM, Jordani MC, et al. Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies. International Journal of Molecular Sciences. 2019;11-20. https://doi.org/10.3390/ijms20205034
Li X, Min L, Zhang P. MedicProtective approaches against myocardial ischemia reperfusion injury (Review). Medicine Experimental and Therapeutec Medicine. 2016;12:3823-3829. https://doi.org/10.3892/etm.2016.3877
De Deken J, Rex S, Monbaliu D, Pirenn J, Jochmans I. The Efficacy of Noble Gases in Attenuation of Ischemia Reperfusion Injury: A Systematic Rewiew and Meta-Analyses. Crit Care Med. 2016;44(9):886-896. https://doi.org/10.1097/CCM.0000000000001717
Francis A, Baynosa R. Ischaemia-reperfusion injury and hyperbaric oxygen pathways: areview of cellular mechanisms. Diving and Hyperbaric Medicine. 2017;47(2):51-59. https://doi.org/10.28920/dhm47.2.110-117
Ricardo O, Soares S, Losada DM, et al. Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies. Int J Mol Sci. 2019;11:20(20):5034. https://doi.org/10.3390/ijms20205034
Oliveira APL, Rangel JPP, Raposo V, et al. Allogenic mesenchymal stem cell intravenous infusion in reparation of mild intestinal ischemia/reperfusion injury in New Zealand rabbits1, Pesq Vet Bras. 2018;38(4):710-721. https://doi.org/10.1590/1678-5150-PVB-5061
Gomaraschi M, Calabresi L, Franceschini G. Protective Effects of HDL Against Ischemia/Reperfusion Injury. Front Pharmacol. 2016;25:7:2. https://doi.org/10.3389/fphar.2016.00002
Chernysheva GA, Smol’yakova VI, Plotnikova TM. Myocardial protection with dibornol under conditions of multiple ischemia/reperfusion in rats. Sibirskij zhurnal klinicheskoj i ehksperimental’noj meditsiny. 2020;35(1):151-158. (In Russ.). https://doi.org/10.29001/2073-8552-2020-35-1-151-158
Orlov YuP, Govorova NV, Kolyadko AV. Effect of deferoxamine on iron metabolism, blood rheological properties and endothelial dysfunction in an experimental model of ischemia/reperfusion. Vestnik intensivnoj terapii im. A.I. Saltanova. 2017;2:12-16. (In Russ.).
Sivaraman V, Yellon DM. Pharmacologic Therapy That Simulates Conditioning for Cardiac Ischemic/Reperfusion Injury. J Cardiovasc Pharmacol Ther. 2014;19(1):83-96. https://doi.org/10.1177/1074248413499973
Shilov AM. Antihypoxants and antioxidants (Actovegin) in the prevention and treatment of cardiovascular complications. Farmateka. 2013;9:42-48. (In Russ.).
Sinning C, Westermann D, Clemmensen P. Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives. Biomark Med. 2017;11(11):11031-1040. https://doi.org/10.2217/bmm-2017-0110
Orlov YuP. Correction of rheological disorders using succinate solutions (exchange of experience). SPb. 2015. (In Russ.).
Kula-Alwar D, Prag HA, Krieg T. Targeting Succinate Metabolism in Ischemia/Reperfusion Injury. Circulation. 2019;140:1968-1970. https://doi.org/10.1161/CIRCULATIONAHA.119.042791
Novitskaya-Usenko LV, Tsarev AV. Cardioprotective effect of reamberin in ischemia-reperfusion injury of the myocardium. Obshhaya reanimatologiya. 2016;12(4):44-49. (In Russ.). https://doi.org/10.15360/1813-9779-2016-4-49-56
Mazina NK, Mazin VP, Kovalenko AL. Clinical and economic efficiency of the use of Reamberin in emergency conditions according to meta-analysis. Farmakoehkonomika. 2014;2(4):14-19. (In Russ.).
Golubev AM, Moroz VV, Kuzovlev AN, Sundukov DV. The importance of ischemia-reperfusion in the development of acute lung injury (review). Obshhaya reanimatologiya. 2007;III(3):107-113. (In Russ.).