The Capsule Endoscopy Crohn’s Disease Activity Index, clinical activity and fecal calprotectin level in patients with isolated small intestine lesions

Timerbulatov M.V.; Grishina E.E.; Aitova L.R.; Senderovich E.I.; Ziganshin T.M.

doi:https://doi.org/10.17116/hirurgia202109163

Timerbulatov M.V.

Bashkir State Medical University

ORCID: 0000-0002-6664-1308

Grishina E.E.

Bashkir State Medical University

ORCID: 0000-0002-5621-8266

Aitova L.R.

Bashkir State Medical University

ORCID: 0000-0001-9689-0949

Senderovich E.I.

Bashkir State Medical University

Ziganshin T.M.

Ufa City Clinical Hospital No. 21

The Capsule Endoscopy Crohn’s Disease Activity Index, clinical activity and fecal calprotectin level in patients with isolated small intestine lesions

Authors:

Timerbulatov M.V., Grishina E.E., Aitova L.R., Senderovich E.I., Ziganshin T.M.

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Journal: Pirogov Russian Journal of Surgery. 2021;(9): 63‑70

DOI: 10.17116/hirurgia202109163

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To cite this article:

Timerbulatov MV, Grishina EE, Aitova LR, Senderovich EI, Ziganshin TM. The Capsule Endoscopy Crohn’s Disease Activity Index, clinical activity and fecal calprotectin level in patients with isolated small intestine lesions. Pirogov Russian Journal of Surgery. 2021;(9):63‑70. (In Russ.)
https://doi.org/10.17116/hirurgia202109163

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

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Abstract:

OBJECTIVE

To identify a correlation between diagnostic markers of Crohn’s disease and endoscopic data using the Capsule Endoscopy Crohn’s Disease Activity Index for isolated small intestine lesions.

MATERIAL AND METHODS

We studied 127 patients over previous 19 years. All patients were divided into 2 groups: isolated Crohn’s disease of small intestine (group 1) and lesion of small and large intestine or large intestine only (group 2). All patients underwent capsule enteroscopy (MiroCam system, South Korea). Clinical activity of Crohn’s disease was determined using the Best’s scale, endoscopic activity — using the the Capsule Endoscopy Crohn’s Disease Activity Index. We also analyzed fecal calprotectin and other laboratory markers.

RESULTS

We found moderate correlation between fecal calprotectin and clinical activity of Crohn’s disease, as well as endoscopic activity, C-reactive protein and leukocytes in overall sample of patients. There was moderate correlation between endoscopic activity and clinical activity in overall sample of patients. We found no correlation between fecal calprotectin and endoscopic activity, endoscopic activity and clinical activity, endoscopic activity and C-reactive protein and leukocytes in patients with isolated small bowel disease. Isolated small intestine lesion is accompanied by significantly lower level of fecal calprotectin compared to lesion of small and large intestine.

CONCLUSION

In isolated small intestine lesion, endoscopic data do not correlate with clinical symptoms and fecal calprotectin level. Thus, analysis of severity of disease using the Crohn’s Disease Clinical Activity Scale alone and fecal calprotectin may not always be effective for isolated small bowel lesion.

Keywords:

capsule enteroscopy

The Capsule Endoscopy Crohn’s Disease Activity Index

Crohn’s disease activity

fecal calprotectin

isolated small bowel Crohn’s disease

Authors:

Timerbulatov M.V.

Bashkir State Medical University

ORCID: 0000-0002-6664-1308

Grishina E.E.

Bashkir State Medical University

ORCID: 0000-0002-5621-8266

Aitova L.R.

Bashkir State Medical University

ORCID: 0000-0001-9689-0949

Senderovich E.I.

Bashkir State Medical University

Ziganshin T.M.

Ufa City Clinical Hospital No. 21

Received:

07.09.2020

Accepted:

14.10.2020

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References:

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