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Ushkalova E.A.
Peoples’ Friendship University of Russia (RUDN University)
Zyryanov S.K.
Peoples’ Friendship University of Russia (RUDN University)
Zatolochina K.E.
Peoples’ Friendship University of Russia (RUDN University)
Symptomatic slow-acting drugs in the treatment of osteoarthritis: focus on glucosamine preparations
Journal: Pirogov Russian Journal of Surgery. 2020;(10): 104‑111
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To cite this article:
Ushkalova EA, Zyryanov SK, Zatolochina KE. Symptomatic slow-acting drugs in the treatment of osteoarthritis: focus on glucosamine preparations. Pirogov Russian Journal of Surgery.
2020;(10):104‑111. (In Russ.)
https://doi.org/10.17116/hirurgia2020101104
The article discusses the place of symptomatic slow-acting drugs in current guidelines for the treatment of osteoarthritis. Special emphasis is put ot glucosamine preparations, the attitude towards which, until recently, was ambiguous. The results of experimental and clinical studies demonstrating the advantages of crystalline glucosamine sulfate over preparations/food additives of glucosamine hydrochloride are presented. The differences in the pharmacodynamics and pharmacokinetics of glucosamine sulfate and glucosamine hydrochloride, which may be the reason for the ineffectiveness of the latter in clinical trials, are discussed.
Keywords:
Authors:
Ushkalova E.A.
Peoples’ Friendship University of Russia (RUDN University)
Zyryanov S.K.
Peoples’ Friendship University of Russia (RUDN University)
Zatolochina K.E.
Peoples’ Friendship University of Russia (RUDN University)
Received:
03.08.2020
Accepted:
26.08.2020
List of references:
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