OBJECTIVE

To identify the correlations between volemic status and serum pro-ANP.

MATERIAL AND METHODS

There were 30 cardiac surgical patients. Hemodynamic monitoring included stroke volume variation, stroke volume, and cardiac output. Serum pro-ANP and volemic status were intraoperatively analyzed at 8 stages including Teboul tests.

RESULTS

Serum pro-ANP at the end of surgery was 2.27 [1.5; 2.5] times higher compared to the baseline value. At the beginning of surgery serum pro-ANP was 102 [89; 185] pg/ml, at the end of surgery — 276 [171; 324] pg/ml. The majority of patients were non-responders according to Teboul test after induction of anesthesia and at the end of surgery. Serum pro-ANP was similar before and after functional tests. Stroke volume variation was 12% [8; 15] at the end of cardiopulmonary bypass and 5-10% in other points. Cumulative fluid balance was 1830 [1440; 2400] ml. No correlations between infusion rate, volume and serum pro-ANP were observed.

CONCLUSION

Serum pro-ANP increased after cardiopulmonary bypass regardless of type and duration of surgery. No correlations between functional tests, hemodynamics, fluid balance and serum pro-ANP were detected.