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Sotnikov O.S.

Pavlov Institute of Physiology

Vasyagina T.I.

Volga Research Medical University

Mitochondria of cardiomyocytes after excessive physical activity

Authors:

Sotnikov O.S., Vasyagina T.I.

More about the authors

Journal: Russian Cardiology Bulletin. 2022;17(3): 44‑50

DOI: 10.17116/Cardiobulletin20221703144

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Table of contents

MITOCHONDRIA OF CARDIOMYOCYTES AFTER EXCESSIVE PHYSICAL ACTIVITY
MITOCHONDRIA OF CARDIOMYOCYTES AFTER EXCESSIVE PHYSICAL ACTIVITY

To cite this article:

Sotnikov OS, Vasyagina TI. Mitochondria of cardiomyocytes after excessive physical activity. Russian Cardiology Bulletin. 2022;17(3):44‑50. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20221703144

Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To identify the range of acceptable morphological changes in mitochondria of cardiomyocytes of animals after a single excessive physical activity.

MATERIAL AND METHODS

Morphological and functional research of 24 mongrel male dogs was carried out. We used treadmill running until complete cessation of animal’s motor activity according to the method proposed by Arakawa K. Structure of cardiomyocytes in subepicardial zone of the right atrium was studied by transmission electron microscopy.

RESULTS

There was morphological multikinetics of mitochondrial crist in normal functioning, as well as acute rearrangement of cardiomyocytes during excessive physical exertion. Excessive physical activity causes massive proteolysis of contractile proteins with abundant edema of cardiomyocytes and functionally significant changes in mitochondria. Destruction of the main energy organelles with appearance of a large number of lysosomes coincide with decrease in motor activity of the animal.

CONCLUSION

The range of maximum permissible morphological changes under extreme physiological loads in dogs apparently consists in proteolysis-dependent edema of cardiomyocytes, violation of protein-lipid relationship in crysts with their separation from peripheral membrane and dense contacts of deproteinized lipid membranes of mitochondria.

Keywords:

physical activity
cardiomyocytes
electron microscopy of cardiomyocytes
mitochondrial morphology
mitochondrial cristae

Authors:

Sotnikov O.S.

Pavlov Institute of Physiology

Vasyagina T.I.

Volga Research Medical University

Received:

21.06.2021

Accepted:

12.04.2022

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