Idiopathic Deep Vein Thrombosis: Choosing a Screening Strategy for Detecting Occult Cancer

Kalinin R.E.; Suchkov I.A.; Zemlyanukhin S.P.

doi:https://doi.org/10.17116/flebo202014021142

Kalinin R.E.

I.P. Pavlov Ryazan State Medical University, Ryazan

ORCID: 0000-0002-0817-9573

Suchkov I.A.

I.P. Pavlov Ryazan State Medical University, Ryazan

SPIN RSCI: 6473-8662
Scopus AuthorID: 56001271800
ResearcherID: M-1180-2016
ORCID: 0000-0002-1292-5452

Zemlyanukhin S.P.

Academician Pavlov Ryazan State Medical University of the Ministry of Health of Russia, Ryazan, Russia

Idiopathic Deep Vein Thrombosis: Choosing a Screening Strategy for Detecting Occult Cancer

Authors:

Kalinin R.E., Suchkov I.A., Zemlyanukhin S.P.

More about the authors

Journal: Journal of Venous Disorders. 2020;14(2): 142‑148

DOI: 10.17116/flebo202014021142

Read: 2441 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Kalinin RE, Suchkov IA, Zemlyanukhin SP. Idiopathic Deep Vein Thrombosis: Choosing a Screening Strategy for Detecting Occult Cancer. Journal of Venous Disorders. 2020;14(2):142‑148. (In Russ.)
https://doi.org/10.17116/flebo202014021142

Подписка 2026 Флебология (Journal of Venous Disorders)

Использование инфографики авторами научных работ

Close metadata

Abstract:

Idiopathic deep vein thrombosis (DVT) may be the first sign of occult cancer. Screening for occult cancer is recommended for early diagnosis and treatment of malignancies. Exact diagnostic measures at the first stage remain under discussion. Several clinical trials aimed to analyse diagnostic strategies followed by optimal diagnosis of occult cancer were conducted within the last decade. Nevertheless, it is unclear whether a lower rate of occult cancer detection leads to reduced mortality associated with cancer or better survival rates in this population. Advanced screening strategies for occult cancer may potentially be more effective in subgroups with high risk of occult cancer. Risk factors of cancer in patients with idiopathic DVT have been previously identified. These are smoking, previous DVT and advanced age (over 60 years). Clinical prognostic models consisting of numerous risk factors may be promising for risk stratification. However, their validation is required before routine clinical application. Screening strategies for detecting occult cancer in patients with idiopathic DVT are analyzed in the article, the authors discuss the prospects of this issue.

Keywords:

idiopathic deep vein thrombosis

occult cancer

advanced screening

Authors:

Kalinin R.E.

I.P. Pavlov Ryazan State Medical University, Ryazan

ORCID: 0000-0002-0817-9573

Suchkov I.A.

I.P. Pavlov Ryazan State Medical University, Ryazan

SPIN RSCI: 6473-8662
Scopus AuthorID: 56001271800
ResearcherID: M-1180-2016
ORCID: 0000-0002-1292-5452

Zemlyanukhin S.P.

Academician Pavlov Ryazan State Medical University of the Ministry of Health of Russia, Ryazan, Russia

Close metadata

References:

Trousseau A. Phlegmasia alba dolens. 1865;3(94):654.
Bouillaud JB. De l’Obliteration des veines et de son influence sur la formation des hydropisies partielles: consideration sur la hydropisies passive et general. 1823;1:188-204.
Carrier M, Le Gal G, Wells PS, Fergusson D, Ramsay T, Rodger MA. Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? 2008;149(5):323-333.
Nordstrom M, Lindblad B, Anderson H, Bergqvist D, Kjellstrom T. Deep venous thrombosis and occult malignancy: an epidemiological study. 1994;308:891-894.
Cornuz J, Pearson SD, Creager MA, Cook EF, Goldman L. Importance of findings on the initial evaluation for cancer in patients with symptomatic idiopathic deep venous thrombosis. 1996;125(10):785-793.
Piccioli A, Lensing AW, Prins MH, Falanga A, Scannapieco GL, Ieran M, Cigolini M, Ambrosio GB, Monreal M, Girolami A, Prandoni P; SOMIT Investigators Group. Extensive screening for occult malignant disease in idiopathic venous thromboembolism: a prospective randomized clinical trial. 004;2(6):884-889.
Monreal M, Lensing AWA, Prins MH, Bonet M, Fernández-Llamazares J, Muchart J, Prandoni P, Angel Jiménez J. Screening for occult cancer in patients with acute deep vein thrombosis or pulmonary embolism. 2004;2(6):876-881.
Di Nisio M, Otten HM, Piccioli A, Lensing AWA, Prandoni P, Büller HRM, Prins H. Decision analysis for cancer screening in idiopathic venous thromboembolism. 2005;3(11):2391-2396.
London: NICE; 2015.
Carrier M, Lazo-Langner A, Shivakumar S, Tagalakis V, Zarychanski R, Solymoss S, Routhier N, Douketis J, Danovitch K, Lee AY, Le Gal G, Wells PS, Corsi DJ, Ramsay T, Coyle D, Chagnon I, Kassam Z, Tao H, Rodger MA; SOME Investigators. Collaborators: Carrier M, Castellucci L, Code C, Corsi DJ, Coyle D, Danovitch K, Le Gal G, Forgie M, Gandara E, Gonsalves C, Karovitch A, Pecarskie A, Ramsay T, Rodger MA, Scarvelis D, Tao H, Wells PS, Corpuz R, Kassam Z, Lazo-Langner A, Taves D. Screening for occult cancer in unprovoked venous thromboembolism. 2015;373(8):697-704.
Robin P, Le Roux PY, Planquette B, Accassat S, Roy PM, Couturaud F, Ghazzar N, Prevot-Bitot N, Couturier O, Delluc A, Sanchez O, Tardy B, Le Gal G, Salaun P. Limited screening with versus without (18)F-fluorodeoxyglucose PET/CT for occult malignancy in unprovoked venous thromboembolism: an open-label randomised controlled trial. 2016; 17(2):193-199.
Van Doormaal FF, Terpstra W, Van Der Griend R, Prins MH, Nijziel MR, Van De Ree MA, Büller HR, Dutilh JC, ten Cate-Hoek A, Van Den Heiligenberg SM, Van Der Meer J, Otten JM. Is extensive screening for cancer in idiopathic venous thromboembolism warranted? 2011; 9(1):79-84.
Marks MA, Engels EA. Venous thromboembolism and cancer risk among elderly adults in the United States. 2014; 23(5):774-783.
Prandoni P, Bernardi E, Valle FD, Visonà A, Tropeano PF, Bova C, Bucherini E, Islam MS, Piccioli A. Extensive computed tomography versus limited screening for detection of occult cancer in unprovoked venous thromboembolism: a multicenter, controlled, randomized clinical trial. 2016;42(8):884-890.
Vaidyanathan S, Walsh J, Cliffe H, Saleema N, Westona MJ, Loweb AS, Chowdhurya FU. Utility of additional abdominopelvic CT in detecting occult cancer in patients with unprovoked venous thromboembolism. 2016;71(6):501-506.
Coyle K, Carrier M, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Solymoss S, Routhier N, Douketis J, Coyle D. Cost effectiveness of the addition of a comprehensive CT scan to the abdomen and pelvis for the detection of cancer after unprovoked venous thromboembolism. 2017;151:67-71.
Khan F, Carrier M, Rodger M. Cancer screening after unprovoked venous thromboembolism: a teachable moment. 2016;176: 739-740.
Khorana AA, Carrier M, Garcia DA, Lee AY. Guidance for the prevention and treatment of cancer-associated venous thromboembolism. 2016;41(1):81-91.
Ihaddadene R, Corsi DJ, Lazo-Langner A, Shivakumar S, Zarychanski R, Tagalakis V, Solymoss S, Routhier N, Douketis J, Le Gal G, Carrier M. Risk factors predictive of occult cancer detection in patients with unprovoked venous thromboembolism. 2016;127(16):2035-2037.
Jara-Palomares L, Otero R, Jimenez D, Carrier M, Tzoran I, Brenner B, Margeli M, Praena-Fernandez JM, Grandone E, Monreal M. Development of a risk prediction score for occult cancer in patients with VTE. 2017;151(3):564-571.
Van Es N, Le Gal G, Otten HM, Robin P, Piccioli A, Lecumberri R, Carrier M. Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism. 2017;167(6):410.
Rosell A, Lundström S, Mackman N, Wallén H, Thålin CH. A clinical practice-based evaluation of the RIETE score in predicting occult cancer in patients with venous thromboembolism. 2019;48(1):111-118.
Gaciong Z, Pruszczyk P, Religa P. Cancer screening in unprovoked venous thromboembolism. 2015;373(25):2474-2475.
Salih M, Gashouta M, Leung E, Algarod T, Ayan M. Extensive screening for occult malignancy in unprovoked venous thromboembolism: a meta-analysis of randomized controlled trials. American Thoracic Society 2016 International Conference. 2016;193:A5719.
Kalinin RE, Suchkov IA, Pshennikov AS, Agapov AB. Evaluation of efficacy and safety of different types of anticoagulant therapy in venous thrombosis. 2015;23(4):416-423. (In Russ.)
Agapov AB, Suchkov IA, Ryabkov AN. Direct oral anticoagulants in patients with deep venous thrombosis of lower extremities. 2016;4(2):147-157. (In Russ.)
Kalinin RE, Suchkov IA, Agapov AB. The Effectiveness of the Various Options of Anticoagulant Therapy for the Treatment of the Patients with Thrombosis of the Deep Veins of the Lower Extremities in the Routine Clinical Practice. 2017;11(1):21-27. (In Russ.)
Vardanyan AV, Badanyan AL, Mumladze RB, Patrushev LI, Roytman EV, Dolidze DD, Tokarev KYu. Idiopathic deep vein thrombosis: modern approaches to diagnostics and treatment. 2014;8(2):16-20. (In Russ.)
Dvoretsky LI. Paraneoplastic thrombophilias. from trousseau to present days. 2019;14(2):385-390. (In Russ.)
Tarabrin OA, Mazurenko AI. Hemostasis System Disorders in Oncological Patients. 2015;3:48-56. (In Russ.)
Andriyashkin AV, Andriyashkin VV, Arutyunov GP, Barinov VE, Bitsadze VO, Bodykhov MK, Britov AN, Butenko AV, Vavilova TV, Vorobyeva NA, Voskanyan YuE, Gavrilenko AV, Galstyan GM, Gelfand BR, Gilyarov MYu, Golubev GSh, Zamyatin MN, Zolotukhin IA, Kobalava ZhD, Katelnitsky II, Kopenkin SS, Kuznetsov MR, Leontyev SG, Lobastov KV, Lubnin AYu, Makatsaria AD, Moiseev VS, Momot AP, Ostryakova EV, Panchenko EP, Perekhodov SN, Piradov MA, Poddubnaya IV, Pokrovsky AV, Protsenko DN, Prudkov MI, Pryadko SI, Pyregov AV, Reshetnyak TM, Ryabinkina YuV, Sapelkin SV, Semyonova MN, Smirnov SV, Sokolov VA, Stahovskaya LV, Stoyko YuM, Sulimov VA, Sukhikh GT, Tereshchenko SN, Fokin AA, Khruslov MV, Shevela AI, Shimanko AI, Shulutko AM, Yavelov IS, Yakhontov DI. Russian clinical recommendations for diagnostics, treatment and prevention of venous thromboembolic complications (VTEO). 2015;9(4-2):1-52. (In Russ.)