Aim. To study the results of the staged combined treatment of the patients presenting with class C1 chronic venous diseases (CVD). Material and methods. We analyzed the results of the treatment of 28 patients with class C1 X3B chronic venous diseases. The following variables were evaluated before and after the treatment: venous clinical severity score (VCSS), malleolar region perimeter, the linear blood flow velocity, the quality of life, and expectations of benefits from the treatment using the Darvall questionnaire. The combined treatment was given during one month and included compression therapy and phlebotherapy (n=28). It was followed by microsclerotherapy in 12 patients. Results. One month after the  onset of the combined treatment of 28 patients, they experienced a decrease of the total VCSS score from 6.5 [95% CI 8.00—7.41 to 4.0 95% CI 2.00—5.41] (p=0.0001) and  the integral quality of life index from 44 [95% 41.00—48.41 to 29 95% CI 24.58—35.66] (p<0,0001) as well as a significant reduction of the malleolar region perimeter on both lower extremities. Moreover, the expectations of benefits from the treatment based on the Darvall questionnaire were fully justified. Microsclerotherapy given to 12 patients resulted in the further improvement of the above characteristics even though these changes lost statistical significance. At the same time, the patients were more satisfied with the aesthetic outcomes of the treatment than those managed without microsclerotherapy. Conclusion. The spectrum of complaints and deterioration of the quality of life in the patients presenting with class C1 chronic venous diseases give ground to a physician to prescribe their combined treatment. Compression therapy and pharmacotherapy make it possible to achieve the objectively confirmed improvement of the certain parameters characterizing the state of the lower extremities whereas subsequent microsclerotherapy further increases the satisfaction of the patients with the aesthetic results of the treatment.