Experimental models of venous thrombosis and cell technologies for thrombotic states' correction

Kuznetsova I.V.; Shevela A.I.; Morozov V.V.; Novikova Ia.V.; Marchukov S.V.; Sevostyanova K.S.; Maĭborodin I.V.

doi:https://doi.org/

Kuznetsova I.V.

Shevela A.I.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

ORCID: 0000-0002-3164-9377

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Novikova Ia.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Marchukov S.V.

Tsentr novykh meditsinskikh tekhnologiĭ Instituta khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Sevostyanova K.S.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

ORCID: 0000-0002-4110-8187

Maĭborodin I.V.

NII klinicheskoĭ i éksperimental'noĭ limfologii SO RAMN, Novosibirsk

Experimental models of venous thrombosis and cell technologies for thrombotic states' correction

Authors:

Kuznetsova I.V., Shevela A.I., Morozov V.V., Novikova Ia.V., Marchukov S.V., Sevostyanova K.S., Maĭborodin I.V.

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Journal: Journal of Venous Disorders. 2012;6(1): 43‑47

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Kuznetsova IV, Shevela AI, Morozov VV, Novikova IaV, Marchukov SV, Sevostyanova KS, Maĭborodin IV. Experimental models of venous thrombosis and cell technologies for thrombotic states' correction. Journal of Venous Disorders. 2012;6(1):43‑47. (In Russ.)

Подписка 2026 Флебология (Journal of Venous Disorders)

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Abstract:

Based on the analysis of a large volume of the literature data concerning simulation of thrombotic conditions in laboratory animals under experimental conditions, the authors discuss various models of venous thrombosis. The method proposed by S. Wessler et al. (1959) is considered to be the simplest, most readily reproducible, and least invasive one. It consists of a combination of venous hyperemia and hypercoagulation induced by the administration of an activated coagulation factor. It should be emphasized that the literature contains only indirect data on the possibility of applying cellular technologies for thrombus recanalization and acceleration of collateral development in ischemic tissues. Moreover, there are no data giving evidence of the vascular growth in the tissue region of thrombosis following the administration of multipotent stem cells.

Keywords:

venous thrombosis

experimental method

cellular technologies

Authors:

Kuznetsova I.V.

Shevela A.I.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

ORCID: 0000-0002-3164-9377

Morozov V.V.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

Novikova Ia.V.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Marchukov S.V.

Tsentr novykh meditsinskikh tekhnologiĭ Instituta khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Sevostyanova K.S.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

ORCID: 0000-0002-4110-8187

Maĭborodin I.V.

NII klinicheskoĭ i éksperimental'noĭ limfologii SO RAMN, Novosibirsk

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