Interval colorectal cancer in patients with colon polyps

Solonitsyn EG, Seyfedinova SSh, Kashchenko VA, et al. . Interval colorectal cancer in patients with colon polyps. Endoscopic Surgery. 2022;28(1):11‑19. (In Russ.)
https://doi.org/10.17116/endoskop20222801111

Подписка 2026 Эндоскопическая хирургия (Endoscopic Surgery)

Использование инфографики авторами научных работ

Close metadata

BACKGROUND

Colorectal cancer (CRC) makes up a significant share in the overall structure of cancer, and mortality from it remains high. Patients with colon polyps have an increased risk of colorectal cancer and should be closely monitored. However, even when all criteria for a high-quality colonoscopy are met, the prevalence of interval colorectal cancer (iCRC) remains significant.

OBJECTIVE

The aim of our study was to determine the incidence of iCRC depending on the number and size of colon polyps. In addition, we evaluated the dynamics of recurrent colorectal polyps.

MATERIALS AND METHODS

A retrospective multicenter cohort study enrolled 733 patients with colon polyps between 2002 and 2020. The data on the patterns of detection of recurrent colorectal polyps and iCRC were evaluated and statistically processed.

RESULTS

Between 2002 and 2020, 733 patients underwent 3240 colonoscopy. Recurrent colon polyps were found in 86% of patients. In patients with primary large polyps, other large polyps were again detected 4.5 times more often than in patients with small polyps. In 14% of patients with previously identified polyps less than 1 cm, newly formed polyps larger than 1 cm were encountered. 16 cases of colorectal adenocarcinoma were identified, which amounted to 2.1% of the total sample. In 13 patients (81%), the surveillance interval corresponded to the recommended one.

CONCLUSION

The majority of patients with colon polyps had recurrent polyps. Patients with both large and small polyps are at risk of iCRC, however, patients with large polyps are 6 times more likely to have ICRC.

Keywords:

intermittent colorectal cancer

observation interval

colon polyps

recurrent colon polyps

Authors:

Solonitsyn E.G.

Almazov National Medical Research Center

SPIN RSCI: 1112-6559
Scopus AuthorID: 26435567100
ResearcherID: O-4145-2015
ORCID: 0000-0002-0794-232X

Seyfedinova S.Sh.

Almazov National Medical Research Centre

ORCID: 0000-0003-3389-5309

Kashchenko V.A.

Sokolov North-Western District Scientific Clinical Center;
St. Petersburg State University

ORCID: 0000-0002-4958-5850

Danilov I.N.

Almazov National Medical Research Centre

SPIN RSCI: 3267-5056
Scopus AuthorID: 25421340800
ORCID: 0000-0001-9540-7812

Fedorov E.D.

Pirogov Russian National Research Medical University of the Russian Ministry of Health

SPIN RSCI: 6785-9959
Scopus AuthorID: 7004381289
ORCID: 0000-0002-6036-7061

Vanyan A.V.

L.G. Sokolov North-West Regional Scientific and Clinical Center

SPIN RSCI: 5021-1667
ORCID: 0000-0002-3686-4666

Mitrakov A.A.

Nizhny Novgorod Regional Clinical Oncology Center

Scopus AuthorID: 55889363300
ORCID: 0000-0002-8376-5679

Prikhodko K.S.

Nizhny Novgorod Regional Clinical Oncology Center

ORCID: 0000-0002-4193-4753

Received:

30.08.2021

Accepted:

01.10.2021

Close metadata

References:

Brenner H, Altenhofen L, Katalinic A, Lansdorp-Vogelaar I, Hoffmeister M. Sojourn time of preclinical colorectal cancer by sex and age: estimates from the German national screening colonoscopy database. Am J Epidemiol. 2011;174(10):1140-1146. https://doi.org/10.1093/aje/kwr188
Poddubnyj BK, Kashin SV, Politov JaV, Kuvaev RO. Colorectal cancer and precancerous pathology: new methods of endoscopic diagnosis and requirements for the preparation of the colon. Prilozhenie Russkogo Medicinskogo Zhurnala «Bolezni Organov Pishhevarenija» №2. Accessed June 24, July 2021. (In Russ.).
Nayor J, Saltzman JR, Campbell EJ, Perencevich ML, Jajoo K, Richter JM. Impact of physician compliance with colonoscopy surveillance guidelines on interval colorectal cancer. Gastrointest Endosc. 2017;85(6):1263-1270. https://doi.org/10.1016/j.gie.2016.10.041
Provenzale D, Ness RM, Llor X, Jennifer M Weiss, Benjamin Abbadessa, Gregory Cooper, Dayna S Early, Mark Friedman, Francis M Giardiello, Kathryn Glaser, Suryakanth Gurudu, Amy L Halverson, Rachel Issaka, Rishi Jain, Priyanka Kanth, Trilokesh Kidambi, Audrey J Lazenby, Lillias Maguire, Arnold J Markowitz, Folasade P May, Robert J Mayer, Shivan Mehta, Swati Patel, Shajan Peter, Peter P Stanich, Jonathan Terdiman, Jennifer Keller, Mary A Dwyer, Ndiya Ogba. NCCN Guidelines Insights: Colorectal Cancer Screening, Version 2.2020. J Natl Compr Canc Netw. 2020;18(10):1312-1320. Published 2020 Oct 1. https://doi.org/10.6004/jnccn.2020.0048
Atkin W, Wooldrage K, Brenner A, Martin J, Shah U, Perera S, Lucas F, Brown JP, Kralj-Hans I, Greliak P, Pack K, Wood J, Thomson A, Veitch A, Duffy SW, Cross AJ. Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study. Lancet Oncol. 2017;18(6):823-834. https://doi.org/10.1016/S1470-2045(17)30187-0
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):359-386. https://doi.org/10.1002/ijc.29210
Cottet V, Jooste V, Fournel I, Bouvier AM, Faivre J, Bonithon-Kopp C. Long-term risk of colorectal cancer after adenoma removal: a population-based cohort study. Gut. 2012;61(8):1180-1186. https://doi.org/10.1136/gutjnl-2011-300295
Click B, Pinsky PF, Hickey T, Doroudi M, Schoen RE. Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence. JAMA. 2018;319(19):2021-2031. https://doi.org/10.1001/jama.2018.5809
Dong SH, Huang JQ, Chen JS. Interval colorectal cancer: a challenging field in colorectal cancer. Future Oncol. 2018;14(13):1307-1316. https://doi.org/10.2217/fon-2017-0439
Jeong YH, Kim KO, Park CS, Kim SB, Lee SH, Jang BI. Risk Factors of Advanced Adenoma in Small and Diminutive Colorectal Polyp. J Korean Med Sci. 2016;31(9):1426-1430. https://doi.org/10.3346/jkms.2016.31.9.1426
Schoefl R, Ziachehabi A, Wewalka F. Small colorectal polyps. Dig Dis. 2015;33(1):38-41. https://doi.org/10.1159/000366034
Rembacken B, Hassan C, Riemann JF, Chilton A, Rutter M, Dumonceau JM, Omar M, Ponchon T. Quality in screening colonoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE). Endoscopy. 2012;44(10):957-968. https://doi.org/10.1055/s-0032-1325686
Tanaka S, Saitoh Y, Matsuda T, Igarashi M, Matsumoto T, Iwao Y, Suzuki Y, Nishida H, Watanabe T, Sugai T, Sugihara K, Tsuruta O, Hirata I, Hiwatashi N, Saito H, Watanabe M, Sugano K, Shimosegawa T. Evidence-based clinical practice guidelines for management of colorectal polyps. J Gastroenterol. 2015;50(3):252-260. https://doi.org/10.1007/s00535-014-1021-4
Hao Y, Wang Y, Qi M, He X, Zhu Y, Hong J. Risk Factors for Recurrent Colorectal Polyps. Gut Liver. 2020;14(4):399-411. https://doi.org/10.5009/gnl19097
Lieberman DA, Weiss DG, Harford WV, Ahnen DJ, Provenzale D, Sontag SJ, Schnell TG, Chejfec G, Campbell DR, Kidao J, Bond JH, Nelson DB, Triadafilopoulos G, Ramirez FC, Collins JF, Johnston TK, McQuaid KR, Garewal H, Sampliner RE, Esquivel R, Robertson D. Five-year colon surveillance after screening colonoscopy. Gastroenterology. 2007;133(4):1077-1085. https://doi.org/10.1053/j.gastro.2007.07.006
Hassan C, Antonelli G, Dumonceau JM, Regula J, Bretthauer M, Chaussade S, Dekker E, Ferlitsch M, Gimeno-Garcia A, Jover R, Kalager M, Pellisé M, Pox C, Ricciardiello L, Rutter M, Helsingen LM, Bleijenberg A, Senore C, van Hooft JE, Dinis-Ribeiro M, Quintero E. Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline — Update 2020. Endoscopy. 2020;52(8):687-700. https://doi.org/10.1055/a-1185-3109
Gupta S, Lieberman D, Anderson JC, Burke CA, Dominitz JA, Kaltenbach T, Robertson DJ, Shaukat A, Syngal S, Rex DK. Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2020;115(3):415-434. https://doi.org/10.14309/ajg.0000000000000544
Singh S, Singh PP, Murad MH, Singh H, Samadder NJ. Prevalence, risk factors, and outcomes of interval colorectal cancers: a systematic review and meta-analysis. Am J Gastroenterol. 2014;109(9):1375-1389. https://doi.org/10.1038/ajg.2014.171
Sanduleanu S, le Clercq CM, Dekker E, Meijer GA, Rabeneck L, Rutter MD, Valori R, Young GP, Schoen RE. Definition and taxonomy of interval colorectal cancers: a proposal for standardising nomenclature. Gut. 2015;64(8):1257-1267. https://doi.org/10.1136/gutjnl-2014-307992
Samadder NJ, Curtin K, Tuohy TM, Pappas L, Boucher K, Provenzale D, Rowe KG, Mineau GP, Smith K, Pimentel R, Kirchhoff AC, Burt RW. Characteristics of missed or interval colorectal cancer and patient survival: a population-based study. Gastroenterology. 2014;146(4):950-960. https://doi.org/10.1053/j.gastro.2014.01.013
Faiss S. The missed colorectal cancer problem. Dig Dis. 2011;29(suppl 1):60-63. https://doi.org/10.1159/000331119
Kluge MA, Williams JL, Wu CK, Jacobson BC, Schroy PC 3rd, Lieberman DA, Calderwood AH. Inadequate Boston Bowel Preparation Scale scores predict the risk of missed neoplasia on the next colonoscopy. Gastrointest Endosc. 2018;87(3):744-751. https://doi.org/10.1016/j.gie.2017.06.012
Calderwood AH, Schroy PC 3rd, Lieberman DA, Logan JR, Zurfluh M, Jacobson BC. Boston Bowel Preparation Scale scores provide a standardized definition of adequate for describing bowel cleanliness. Gastrointest Endosc. 2014;80(2):269-276. https://doi.org/10.1016/j.gie.2014.01.031