Applicability. Laparoscopic cholecystectomy (LCE) is the method of choice in the treatment of chronic calculous cholecystitis. It is well known that laparoscopic surgery have a number of obvious advantages over traditional: minor trauma, a lower level of post-operative pain, excellent cosmetic effect, accelerating the physical and social rehabilitation of patients. Nevertheless, it is shown that postoperative pain is a major cause prolongation of hospitalization in patients after LCE. The objective of this research was to evaluate the effect of preemptive local anesthesia (PLA) solution of 1% ropivacaine on during the early postoperative period. Material and methods. From October 2012 to July 2013 was operated 104 patients in the amount of LCE by standard methods. All patients were divided into 2 groups. First, a basic group (G1) consisted of 48 patients operated using PLA solution of 1% ropivacaine. In the second comparison group (G2) included 56 patients operated without the use of the one. The distribution took place in the group by randomization method. PLA was performed as follows: before the skin incision at the point of trocar accesses a mandatory aspirate was administered a local anesthetic of the amide type ropivacaine 10 mg/ml (1%) (Naropin, Astra Zeneca UK Limited, UK) in an amount of 20 ml for 6 and 4 ml trocars 10 and 5 mm, respectively, infiltrating the muscle, the fascia, preperitoneal fat. At the end of the operation in the abdomen in the area of the right dome of the diaphragm by means of laparoscopic aspirator — irrigator 5 mm was sprayed with 10 ml of 1% ropivacaine solution. Assessment of severity of pain in the postoperative period was performed by a special questionnaire that was based on visual analog — rating scale (VAS ) at 2, 4, 8, 24, 48 and 72 hours after surgery. The data were subjected to variational-statistical processing in accordance with conventional methods. Results. In the early postoperative period, the level of postoperative pain in G1 was significantly lower than in G2 (p<0,001), and not more than 1,02±0,18 points on the VAS. In the T2 level of postoperative pain after 4, 8 and 24 hours on average, greater than 3 points on the VAS. In the G2 level of postoperative pain after 4, 8 and 24 hours on average, greater than 3 points on the VAS. In G2 patients significantly more often haved pain at rest, by coughing and movement (p<0,001). In the G1 pain in the shoulder — scapular region worried 10.4% of patients in the G2 — 48.2% (p<0,001). In the G1 postoperative analgesia was not required in 56.2% of patients, in the G2 51% of patients for adequate analgesia needed 3 injections of ketorol 30 mg. The length of postoperative hospital stay in G1 patients was lower by 1.05 days (p<0,001). The level of post-operative nausea and vomiting, drowsiness and other side effects was not statistically different in both groups (p<0,001). Conclusion. Preemtive local anesthesia with 1% ropivacaine during LCE is an effective and safe method of prevention of intensive post-operative pain in the early postoperative period, and also allows to reduce the length of hospital stay.