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Zybina N.N.

Nikiforov Russian Center of Emergency and Radiation Medicine — EMERCOM of Russia

Nikonov E.L.

Pirogov Russian National Research Medical University

Gershtein E.S.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Memdli Z.Z.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Stilidi I.S.

Blokhin National Medical Research Center of Oncology

Kushlinskii N.E.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review)

Authors:

Zybina N.N., Nikonov E.L., Gershtein E.S., Memdli Z.Z., Stilidi I.S., Kushlinskii N.E.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2022;11(1): 28‑44

DOI: 10.17116/dokgastro20221101128

Read: 7434 times

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Table of contents

ZONULIN IS A MARKER OF EPITHELIAL AND ENDOTHELIAL BARRIER FUNCTIONS IN NON-COMMUNICABLE DISEASES (NARRATIVE REVIEW)
ZONULIN IS A MARKER OF EPITHELIAL AND ENDOTHELIAL BARRIER FUNCTIONS IN NON-COMMUNICABLE DISEASES (NARRATIVE REVIEW)

To cite this article:

Zybina NN, Nikonov EL, Gershtein ES, Memdli ZZ, Stilidi IS, Kushlinskii NE. Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review). Russian Journal of Evidence-Based Gastroenterology. 2022;11(1):28‑44. (In Russ.)
https://doi.org/10.17116/dokgastro20221101128

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The review aims to analyze data published for more than 20 years about the role of zonulin as a biomarker in noncommunicable diseases (autoimmune, meta-bolic, and oncologic).

MAIN STATEMENTS

The structure and functions of tight junctions involved in the regulation of intestinal permeability are discussed. Altered intestinal permea-bility is an essential pathogenetic mechanism of many chronic diseases. Zonulin belongs to the key endogenous regulators of intercellular permea-bility; consequently, many investigations have studied the role of zonulin-related proteins as possible markers of intestinal permeability, particularly in gastrointes-tinal tract diseases. At the same time, increased serum zonulin levels were found in patients with autoimmune diseases and obesity, complicating the adequate in-terpretation of the obtained data. Oncologists are also interested in zonulin-related proteins as deregulation of the zonulin signaling pathway may contribute to the pathogenesis of various diseases associated with intercellular communications al-teration, including malignant transformation and metastasizing. Several recent publications have shown that specific inhibitors or probiotics may modulate zonulin levels with marked clinical effects. An essential aspect of zonulin investigations remains the methodology of its measurement, which according to some authors, requires further improvement.

CONCLUSIONS

Zonulin analysis in serum and other body fluids is a valuable instrument for diagnostics, monitoring, and possibly correcting pathologic pro-cesses associated with disturbances of intestinal permeability and requires further investigation.

Keywords:

zonulin
tight junctions
intestinal permeability
noncommunica-ble diseases
oncologic diseases

Authors:

Zybina N.N.

Nikiforov Russian Center of Emergency and Radiation Medicine — EMERCOM of Russia

Nikonov E.L.

Pirogov Russian National Research Medical University

Gershtein E.S.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Memdli Z.Z.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Stilidi I.S.

Blokhin National Medical Research Center of Oncology

Kushlinskii N.E.

N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation

Received:

11.12.2021

Accepted:

10.02.2022

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