The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Zybina N.N.
Nikiforov Russian Center of Emergency and Radiation Medicine — EMERCOM of Russia
Nikonov E.L.
Pirogov Russian National Research Medical University
Gershtein E.S.
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Memdli Z.Z.
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Stilidi I.S.
Blokhin National Medical Research Center of Oncology
Kushlinskii N.E.
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review)
Journal: Russian Journal of Evidence-Based Gastroenterology. 2022;11(1): 28‑44
Views: 5669
Downloaded: 272
To cite this article:
Zybina NN, Nikonov EL, Gershtein ES, Memdli ZZ, Stilidi IS, Kushlinskii NE. Zonulin is a marker of epithelial and endothelial barrier functions in non-communicable diseases (narrative review). Russian Journal of Evidence-Based Gastroenterology.
2022;11(1):28‑44. (In Russ.)
https://doi.org/10.17116/dokgastro20221101128
The review aims to analyze data published for more than 20 years about the role of zonulin as a biomarker in noncommunicable diseases (autoimmune, meta-bolic, and oncologic).
The structure and functions of tight junctions involved in the regulation of intestinal permeability are discussed. Altered intestinal permea-bility is an essential pathogenetic mechanism of many chronic diseases. Zonulin belongs to the key endogenous regulators of intercellular permea-bility; consequently, many investigations have studied the role of zonulin-related proteins as possible markers of intestinal permeability, particularly in gastrointes-tinal tract diseases. At the same time, increased serum zonulin levels were found in patients with autoimmune diseases and obesity, complicating the adequate in-terpretation of the obtained data. Oncologists are also interested in zonulin-related proteins as deregulation of the zonulin signaling pathway may contribute to the pathogenesis of various diseases associated with intercellular communications al-teration, including malignant transformation and metastasizing. Several recent publications have shown that specific inhibitors or probiotics may modulate zonulin levels with marked clinical effects. An essential aspect of zonulin investigations remains the methodology of its measurement, which according to some authors, requires further improvement.
Zonulin analysis in serum and other body fluids is a valuable instrument for diagnostics, monitoring, and possibly correcting pathologic pro-cesses associated with disturbances of intestinal permeability and requires further investigation.
Keywords:
Authors:
Zybina N.N.
Nikiforov Russian Center of Emergency and Radiation Medicine — EMERCOM of Russia
Nikonov E.L.
Pirogov Russian National Research Medical University
Gershtein E.S.
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Memdli Z.Z.
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Stilidi I.S.
Blokhin National Medical Research Center of Oncology
Kushlinskii N.E.
N.N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of the Russian Federation
Received:
11.12.2021
Accepted:
10.02.2022
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.