Probiotics from the standpoint of evidence-based medicine

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The number of trials and reports devoted to probiotics is steadily increased. Effectiveness of various probiotic strains of microorganisms is reported for metabolic disorders (diabetes, dyslipidemia, obesity), gastrointestinal diseases (inflammatory bowel disease, constipation, antibiotic-associated diarrhea, Clostridium difficile-associated disease, irritable bowel syndrome), atopic diseases (food allergy, rhinitis), liver diseases (cirrhosis, non-alcoholic fatty liver disease, hepatic encephalopathy), pancreatic diseases (acute pancreatitis) and others. Administration of probiotics in clinical practice is associated with some difficulties due to a huge variety of probiotic drugs, the absence of uniform standards for their production, insufficient evidence base regarding the most effective dosages, forms of release, etc. However, specific strains of probiotics effective for each disease are currently determined with various degrees of evidence. There are recommendations regarding a differentiated approach to the selection of probiotics depending on a particular disease.

Keywords:

clostridium difficile-associated disease

irritable bowel syndrome

inflammatory bowel disease

antibiotic-associated diarrhea

probiotics

eradication therapy

Authors:

Kaibysheva V.O.

N.I. Pirogov Russian National Research Medical University, Moscow, Russia;
City Clinical Hospital №31, Moscow, Russia

ORCID: 0000-0003-0114-3700

Nikonov E.L.

FGBU "Poliklinika #1" Upravleniia delami Prezidenta RF

Scopus AuthorID: 57216680476
ResearcherID: T-9090-2017
ORCID: 0000-0003-3021-6534

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