Morphological characteristics of pulmonary tuberculosis concurrent with lung cancer

Novitskaya T.A.; Ariel B.M.; Dvorakovskaya I.V.; Avetisyan A.O.; Yablonsky P.K.

doi:https://doi.org/10.17116/patol20218302119

Novitskaya T.A.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia;
Saint Petersburg State University

Ariel B.M.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia

Dvorakovskaya I.V.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia;
Research Institute of Pulmonology of the Acad. I.P. Pavlov First Saint Petersburg State Medical University

SPIN RSCI: 1660-5201
Scopus AuthorID: 6602427418
ORCID: 0000-0002-0333-751X

Avetisyan A.O.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia

Yablonsky P.K.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia;
Saint Petersburg State University

Morphological characteristics of pulmonary tuberculosis concurrent with lung cancer

Authors:

Novitskaya T.A., Ariel B.M., Dvorakovskaya I.V., Avetisyan A.O., Yablonsky P.K.

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Journal: Russian Journal of Archive of Pathology. 2021;83(2): 19‑24

DOI: 10.17116/patol20218302119

Read: 11652 times

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To cite this article:

Novitskaya TA, Ariel BM, Dvorakovskaya IV, Avetisyan AO, Yablonsky PK. Morphological characteristics of pulmonary tuberculosis concurrent with lung cancer. Russian Journal of Archive of Pathology. 2021;83(2):19‑24. (In Russ.)
https://doi.org/10.17116/patol20218302119

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

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OBJECTIVE

To study the pathogenetic relationship between pulmonary tuberculosis and lung cancer.

MATERIAL AND METHODS

The investigators examined surgical material from 51 patients (41 men) aged 41—73 years (mean age, 63.7 years) with pulmonary tuberculosis concurrent with lung cancer. They also studied tumors, tuberculous caverns, infiltrates, and foci with surrounding macroscopically intact lung tissue, as well as fibrotic changes by histological, histochemical and immunohistochemical examinations.

RESULTS

Previous tuberculosis can be considered as a risk factor for lung cancer. Central cancer was more common in patients with inactive, chronic tuberculosis with a predominance of fibrotic processes in the root of the lung and in its hilar zones. Fibrous-cavernous tuberculosis and cavernous tuberculosis were more frequently concurrent with central cancer; peripheral tumors mainly occurred in infiltrative tuberculosis and tuberculomas.

CONCLUSION

The findings suggest that in a number of cases, cancer and tuberculosis may be anatomically close, developing in the same anatomical unit — the lung. However, this does not indicate an unambiguous etiopathogenetic relationship between pulmonary tuberculosis and lung cancer. The relationships between pulmonary tuberculosis and lung cancer are much more complex and do not fit into the simple scheme of cause-and-effect relations.

Keywords:

tuberculosis

cancer

lung

pathogenesis

Authors:

Novitskaya T.A.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia;
Saint Petersburg State University

Ariel B.M.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia

Dvorakovskaya I.V.

SPIN RSCI: 1660-5201
Scopus AuthorID: 6602427418
ORCID: 0000-0002-0333-751X

Avetisyan A.O.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia

Yablonsky P.K.

Saint Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Health of Russia;
Saint Petersburg State University

Received:

29.10.2020

Accepted:

25.12.2020

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